Results 41 to 50 of about 2,314,582 (300)

Human esophageal fibroblast-derived exosomal miR-21 reduced the cisplatin sensitivity to esophageal carcinoma EC9706 cells

Brazilian Journal of Medical and Biological Research, 2021
The objective of this study was to investigate the effect of human esophageal fibroblast-derived exosomal miR-21 on cisplatin sensitivity against esophageal squamous EC9706 cells. EC9706 cells were co-cultured indirectly with human esophageal fibroblasts
Jiajin Wan, Chunling Niu, Baiyan Wang, Qianqian Han, Yulon Chen, Shuying Feng, Lianhe Yang   +6 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts

BMC Cancer, 2005
Background The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral fibroblasts.
Kanakubo Emi, Samoszuk Michael, Chan John K   +2 more
doaj   +1 more source

M2 macrophage inhibits the antitumor effects of Lenvatinib on intrahepatic cholangiocarcinoma

Frontiers in Immunology, 2023
Background and objectivesThe relationship between the tumor microenvironment and the network of key signaling pathways in cancer plays a key role in the occurrence and development of tumors.
Long Yang, Pinsheng Han, Tao Cui, Tao Cui, Yu Miao, Tianyu Zhao, Zilin Cui, Yijia Chen, Hao Chi, Jieying Zhang, Jieying Zhang, Yamin Zhang   +11 more
doaj   +1 more source

Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor

Journal of Experimental Medicine, 1990
Macrophages and cultured human monocytes can mediate efficient antibody- dependent cytotoxicity (ADCC) against human tumor cells using monoclonal antibodies (mAbs).
David H. Munn, Nai-Kong V. Cheung
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Establishment and evaluation of melanoma model

Journal of Hebei University of Science and Technology, 2018
In order to screen drug rapidly and effectively in vivo, the approach of the establishment for mouse melanoma model with primary cell from melanin solid tumor tissue of mouse is studied.
Xiangli YAO, Xuguang MIAO, Xixi WEI, Xuan WANG, Shouxin LIU   +4 more
doaj   +1 more source

Intraperitoneal Mesenchymal Cells Promote the Development of Peritoneal Metastasis Partly by Supporting Long Migration of Disseminated Tumor Cells. [PDF]

PLoS ONE, 2016
The human peritoneal cavity contains a small number of free cells of mesenchymal cell lineage. Intraperitoneal mesenchymal cells (PMC) play supportive roles in metastasis formation on the peritoneum.
Joji Kitayama, Hironori Yamaguchi, Hironori Ishigami, Keisuke Matsuzaki, Naohiro Sata   +4 more
doaj   +1 more source

Basic fibroblast growth factor as a growth inhibitor for cultured human tumor cells.

Journal of Clinical Investigation, 1987
Basic fibroblast growth factor (bFGF) stimulates the proliferation of many cells and it is found in a wide variety of normal or transformed tissues. As demonstrated here, bFGF is also present in cultured human Ewing's sarcoma cells. Unexpectedly, however,
Lothar Schweigerer, G. Neufeld, D. Gospodarowicz   +2 more
semanticscholar   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

FEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos, Doriana Ricciuti, Giada Mondanelli, Marco Gargaro   +3 more
wiley   +1 more source