Results 41 to 50 of about 2,710,879 (342)

Human macrophage-engineered vesicles for utilization in ovarian cancer treatment

Frontiers in Oncology, 2023
BackgroundOvarian cancer is a deadly female malignancy with a high rate of recurrent and chemotherapy-resistant disease. Tumor-associated macrophages (TAMs) are a significant component of the tumor microenvironment and include high levels of M2-protumor ...
David Schweer, Namrata Anand, Namrata Anand, Abigail Anderson, J. Robert McCorkle, Khaga Neupane, Alexandra N. Nail, Brock Harvey, Kristen S. Hill, Frederick Ueland, Christopher Richards, Jill Kolesar, Jill Kolesar   +12 more
doaj   +1 more source

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. [PDF]

, 2018
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of ...
Aliberti S, Bareja R, Bonvini E, Bruna R, Brusa D, Chiaretti S, Chichili GR, Cignetti A, Circosta P, Deaglio S, Elemento O, Elia AR, Foà R, Giacomo FD, Gottardi D, Guarini AR, Inghirami G., Johnson S, Kyriakides PW, Landra I, Machiorlatti R, Massaia M, Monteleone E, Moore PA, Todaro M   +24 more
core   +1 more source

Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor

Journal of Experimental Medicine, 1990
Macrophages and cultured human monocytes can mediate efficient antibody- dependent cytotoxicity (ADCC) against human tumor cells using monoclonal antibodies (mAbs).
David H. Munn, Nai-Kong V. Cheung
semanticscholar   +1 more source

Thioglycollate-elicited murine macrophages are cytotoxic to Mycoplasma arginini-infected YAC-1 tumor cells

Brazilian Journal of Medical and Biological Research, 1998
Macrophages are important components of natural immunity involved in inhibition of tumor growth and destruction of tumor cells. It is known that these cells can be activated for tumoricidal activity by lymphokines and bacterial products.
F. Ribeiro-Dias, M. Russo, F.R.F. Nascimento, J.A.M. Barbuto, J. Timenetsky, S. Jancar   +5 more
doaj   +1 more source

Intraperitoneal Mesenchymal Cells Promote the Development of Peritoneal Metastasis Partly by Supporting Long Migration of Disseminated Tumor Cells. [PDF]

PLoS ONE, 2016
The human peritoneal cavity contains a small number of free cells of mesenchymal cell lineage. Intraperitoneal mesenchymal cells (PMC) play supportive roles in metastasis formation on the peritoneum.
Joji Kitayama, Hironori Yamaguchi, Hironori Ishigami, Keisuke Matsuzaki, Naohiro Sata   +4 more
doaj   +1 more source

TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer. [PDF]

, 2016
A subgroup of breast cancers has several metabolic compartments. The mechanisms by which metabolic compartmentalization develop in tumors are poorly characterized. TP53 inducible glycolysis and apoptosis regulator (TIGAR) is a bisphosphatase that reduces
Bartrons, Ramon, Birbe, Ruth C., Capparelli, Claudia, Caro, Jaime, Curry, Joseph M., Domingo-Vidal, Marina, Ko, Ying-Hui, Lin, Zhao, Manzano, Anna, Martinez-Outshoorn, Ubaldo E., Navarro-Sabaté, Àurea, Roche, Megan, Seifert, Erin, Tassone, Patrick, Tuluc, Madalina, Whitaker-Menezes, Diana   +15 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Oxygen-dependent contraction and degradation of the extracellular matrix mediated by interaction between tumor and endothelial cells

AIP Advances, 2019
Understanding the mechanisms of cancer development and metastasis requires comprehensive analyses of interactions between normal and tumor cells and the extracellular matrix (ECM) in hypoxic tumor microenvironments.
Daisuke Yoshino, Kenichi Funamoto
doaj   +1 more source

Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts

BMC Cancer, 2005
Background The purpose of this study was to test the hypothesis that mast cells that are present in fibrotic regions of cancer can suppress the growth of tumor cells through an indirect mechanism involving peri-tumoral fibroblasts.
Kanakubo Emi, Samoszuk Michael, Chan John K   +2 more
doaj   +1 more source

M2 macrophage inhibits the antitumor effects of Lenvatinib on intrahepatic cholangiocarcinoma

Frontiers in Immunology, 2023
Background and objectivesThe relationship between the tumor microenvironment and the network of key signaling pathways in cancer plays a key role in the occurrence and development of tumors.
Long Yang, Pinsheng Han, Tao Cui, Tao Cui, Yu Miao, Tianyu Zhao, Zilin Cui, Yijia Chen, Hao Chi, Jieying Zhang, Jieying Zhang, Yamin Zhang   +11 more
doaj   +1 more source