Results 41 to 50 of about 26,025 (289)
Surgery Triggers Outgrowth of Latent Distant Disease in Breast Cancer: An Inconvenient Truth? [PDF]
, 2010 We review our work over the past 14 years that began when we were first confronted with bimodal relapse patterns in two breast cancer databases from different countries. These data were unexplainable with the accepted continuous tumor growth paradigm. To
Baum, Michael +4 more
core +3 more sources
A mathematical model of systemic inhibition of angiogenesis in metastatic development [PDF]
, 2013 We present a mathematical model describing the time development of a population of tumors subject to mutual angiogenic inhibitory signaling. Based on biophysical derivations, it describes organism-scale population dynamics under the influence of three ...
Benzekry, Sebastien +2 more
core +4 more sources
Tumor dormancy and oncogene addiction [PDF]
APMIS, 2008 Cancer is caused by genetic changes that activate oncogenes or inactivate tumor suppressor genes. The repair or inactivation of mutant genes may be effective in the treatment of cancer. Indeed, drugs that target oncogenes can be effective in the treatment of cancer.
openaire +2 more sources
Cancer stem cells, tumor dormancy, and metastasis [PDF]
Frontiers in Endocrinology, 2012 Tumor cells can persist undetectably for an extended period of time in primary tumors and in disseminated cancer cells. Very little is known about why and how these tumors persist for extended periods of time and then evolve to malignancy. The discovery of cancer stem cells (CSCs) in human tumors challenges our current understanding of tumor recurrence,
Patel, Purvi, Chen, Emily I.
openaire +3 more sources
The Potential for Circulating Tumor Cells in Pancreatic Cancer Management. [PDF]
, 2017 Pancreatic cancer is one the most lethal malignancies. Only a small proportion of patients with this disease benefit from surgery. Chemotherapy provides only a transient benefit.
Michael Pimienta +4 more
core +2 more sources
Tumor Cell Dormancy—Triggered by the Niche [PDF]
Developmental Cell, 2019 Dormant cancer cells often survive treatment and increase the risk for tumor relapse, associated with dismal prognosis. Two recent papers describe mechanisms used by the bone marrow niche to regulate leukemia dormancy. The findings provide a molecular basis for niche-targeting therapies that may enable elimination of dormant tumor cells.
Senft, D., Jeremias, I.
openaire +3 more sources
Review of Tumor Dormancy Therapy Using Traditional Oriental Herbal Medicine
Journal of Pharmacopuncture, 2013 Objective: Standard cancer therapy prolongs survival, but can be detrimental to the quality of life, compromise the immune system, and leave residual disease that can cause recurrence years or decades in the future.
Lee Jong-Ho +4 more
doaj +1 more source
Fibroblasts in cancer dormancy: foe or friend?
Cancer Cell International, 2021 Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies.
Li Dai +5 more
doaj +1 more source
Abscisic acid regulates dormancy of prostate cancer disseminated tumor cells in the bone marrow
Neoplasia: An International Journal for Oncology Research, 2021 Prostate cancer (PCa) commonly metastasizes to the bone where the cells frequently undergo dormancy. The escape of disseminated tumor cells from cellular dormancy is a major cause of recurrence in marrow.
Younghun Jung +8 more
doaj +1 more source
Head and neck cancer: metronomic chemotherapy [PDF]
, 2015 In the era of personalized medicine, head and neck squamous cell carcinoma (HNSCC) represents a critical oncologic topic. Conventional chemotherapy regimens consist of drugs administration in cycles near or at the maximum tolerated dose (MDT), followed ...
DE FELICE, FRANCESCA +2 more
core +2 more sources