Results 71 to 80 of about 154,631 (333)

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis [PDF]

, 2015
Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes.
Creytens, David, Geurs, Sarah, Naert, Thomas, Sanders, Ellen, Tran Thi, Hong, Van Imschoot, Griet, Van Nieuwenhuysen, Tom, Van Roy, Frans, Vleminckx, Kris   +8 more
core   +3 more sources

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis [PDF]

, 2020
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor ...
Burgers, Peter M, Chang, Matthew, Cobb, Jennifer A, Ghisays, Fiorella, Hailemariam, Sarem, Hohl, Marcel, Kuryavyi, Vitaly, Mojumdar, Aditya, Patel, Dinshaw J, Petrini, John H. J., Sorenson, Kyle, Taylor, Barry S   +11 more
core   +2 more sources

Tumor lysis syndrome

, 2006
Caroline Rech, Elvino José Guardão Barros   +1 more
openaire   +3 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Intraoperative tumor lysis syndrome in a giant teratoma: a case report

BMC Surgery, 2019
Background Tumor lysis syndrome is an unusual metabolic emergency in solid tumors. Perioperative occurrence of this syndrome is extremely rare but may have fatal consequences if not detected and treated on time.
Daniel Pindak, Katarina Rejlekova, Miroslav Tomas, Ramadan Aziri, Eva Rovenska, Judita Puskacova, Michal Mego   +6 more
doaj   +1 more source

Tumor lysis syndrome: pathogenesis, clinical onsets, prevention, treatment

Онкогематология, 2022
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E. G. Gromova, L. S. Kuznetsova
doaj   +1 more source

Rituximab induced pulmonary edema managed with extracorporeal life support [PDF]

, 2018
Though rare, rituximab has been reported to induce severe pulmonary edema. We describe the first report of ECLS utilization for this indication. A 31-year-old female with severe thrombotic thrombocytopenic purpura developed florid pulmonary edema after ...
Aguilar, Patrick, Balsara, Keki R, Isakow, Warren, Itoh, Akinobu, Masood, Muhammad F, Miller, Jacob R, Sanfilippo, Kristen M   +6 more
core   +3 more sources

Tumor Lysis Syndrome Rare Presentation As Uremic Pericarditis: A Case Report [PDF]

, 2023
Fábio Caleça Emídio, Rafaela Corrêa Pereira, Pedro Martins dos Santos, Teresa Abegão   +3 more
openalex   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Acute respiratory distress syndrome associated with tumor lysis syndrome in a child with acute lymphoblastic leukemia

Pediatric Reports, 2015
Tumor lysis syndrome is a serious and dangerous complication usually associated with antiblastic treatment in some malignancies characterized by high cell turn-over.
Alessandra Macaluso, Selene Genova, Silvio Maringhini, Giancarlo Coffaro, Ottavio Ziino, Paolo D'Angelo   +5 more
doaj   +1 more source