Results 1 to 10 of about 274,732 (177)

Diversity of Dynamics and Morphologies of Invasive Solid Tumors [PDF]

arXiv, 2012
Complex tumor-host interactions can significantly affect the growth dynamics and morphologies of progressing neoplasms. The growth of a confined solid tumor induces mechanical pressure and deformation of the surrounding microenvironment, which in turn influences tumor growth.
Jiao, Yang, Torquato, Sal
arxiv   +4 more sources

Modeling Three-dimensional Invasive Solid Tumor Growth in Heterogeneous Microenvironment under Chemotherapy [PDF]

, 2018
A systematic understanding of the evolution and growth dynamics of invasive solid tumors in response to different chemotherapy strategies is crucial for the development of individually optimized oncotherapy. Here, we develop a hybrid three-dimensional (3D) computational model that integrates pharmacokinetic model, continuum diffusion-reaction model and
Chen, Guo, Fan, Qihui, Hai, Miaomiao, Hu, Zhijian, Jiao, Yang, Liu, Liyu, Liu, Ruchuan, Shuai, Jianwei, Xie, Hang, Yang, Jiaen, Yang, Yue   +10 more
arxiv   +3 more sources

Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Cell Death Discovery, 2023
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng, Jintao Dou, Yi Yang, Shaojie Sun, Ruiqi Chen, Zhijian Zhang, Huijun Wei, Jianhui Li, Zhihao Wu   +8 more
doaj   +1 more source

KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li, Yiyu Wang, Yuan Mou, Hao Wu, Ye Qin   +4 more
doaj   +1 more source

Predicting the Progress of Tuberculosis by Inflammatory Response-Related Genes Based on Multiple Machine Learning Comprehensive Analysis

Journal of Immunology Research, 2023
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma, Peifei Peng, Zhihao Duan, Yifeng Fan, Xinzhi Li   +4 more
doaj   +1 more source

Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells

Cell Communication and Signaling, 2020
Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different ...
Qi Dong, Chenkang Zhou, Haodong Ren, Zhijian Zhang, Feng Cheng, Zhenkai Xiong, Chuantao Chen, Jianke Yang, Jiguang Gao, Yao Zhang, Lei Xu, Jian Fang, Yuxiang Cao, Huijun Wei, Zhihao Wu   +14 more
doaj   +1 more source

Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1

Discover Oncology, 2022
Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li, Yaqi Kou, Xiaohan Zhang, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Shuang Yang   +12 more
doaj   +1 more source

Screening of Molecular Markers of Cisplatin Resistance in Lung Adenocarcinoma and Functional Verification Based on TCGA Database

Zhongliu Fangzhi Yanjiu, 2022
Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin, HUANG Zixian, YOU Chengcheng, TAN Shunzi, HUANG Liming, HUANG Yiling   +5 more
doaj   +1 more source

Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. [PDF]

, 2014
Tumor invasion and metastases represent a complex series of molecular events that portends a poor prognosis. The contribution of inflammatory pathways mediating this process is not well understood. Nod-like receptors (NLRs) of innate immunity function as
Chin, Arnold I, Zhang, Hanwei
core   +9 more sources

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]

, 2020
BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon, Bejnood, Alborz, Bouchard, Gina, Diehn, Maximilian, Feng, Weiguo, Forgó, Erna, Gentles, Andrew J, Hoang, Chuong D, Hui, Angela Bik-Yu, Jeong, Youngtae, Knowles, David A, Kuong, Amanda, Nair, Ramesh V, Nair, Viswam S, Plevritis, Sylvia K, van de Rijn, Matt, Varma, Sushama, West, Rob, Xu, Yue, Yu, Alice   +19 more
core   +4 more sources