Results 1 to 10 of about 3,620,379 (402)

Nonlinear simulation of the effect of microenvironment on tumor growth [PDF]

, 2006
Paul Macklin, John Lowengrub
openalex   +4 more sources

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, 2021
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, J. Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, S. Shi   +9 more
semanticscholar   +1 more source

Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Cell Death Discovery, 2023
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng, Jintao Dou, Yi Yang, Shaojie Sun, Ruiqi Chen, Zhijian Zhang, Huijun Wei, Jianhui Li, Zhihao Wu   +8 more
doaj   +1 more source

Role of tumor microenvironment in cancer progression and therapeutic strategy

Cancer Medicine, 2023
Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its ...
Qingjing Wang, Xue-ting Shao, Yuxuan Zhang, Miaojin Zhu, F. X. Wang, Jianjian Mu, Jia-Xia li, H. Yao, Keda Chen   +8 more
semanticscholar   +1 more source

Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma

Frontiers in Immunology, 2023
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the third leading cause of tumor-related mortality worldwide. In recent years, the emergency of immune checkpoint inhibitor (ICI) has revolutionized the management of HCC ...
Chen Chen, Zehua Wang, Y. Ding, Yanru Qin   +3 more
semanticscholar   +1 more source

Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Cell Death and Disease, 2023
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.
Yan Zhao, Meili Shen, Liangqiang Wu, Haiqin Yang, Yixuan Yao, Qingbiao Yang, Jianshi Du, Linlin Liu, Yapeng Li, Yuansong Bai   +9 more
semanticscholar   +1 more source

Predicting the Progress of Tuberculosis by Inflammatory Response-Related Genes Based on Multiple Machine Learning Comprehensive Analysis

Journal of Immunology Research, 2023
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma, Peifei Peng, Zhihao Duan, Yifeng Fan, Xinzhi Li   +4 more
doaj   +1 more source

Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials

Molecular Cancer, 2023
Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal component of the tumor microenvironment.
Hao Zhang, Xinghai Yue, Zhe Chen, Chao Liu, Wantao Wu, Nan Zhang, Zao-bin Liu, Liping Yang, Qing Jiang, Quan Cheng, Peng Luo, Guodong Liu   +11 more
semanticscholar   +1 more source

KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li, Yiyu Wang, Yuan Mou, Hao Wu, Ye Qin   +4 more
doaj   +1 more source

Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics

Journal of Hematology & Oncology, 2023
Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways ...
Haoran Jin, Jin Wang, Zi-Jing Wang, Mingjia Xi, Bi-Han Xia, Kai Deng, Jin-Lin Yang   +6 more
semanticscholar   +1 more source