Results 1 to 10 of about 3,438,472 (318)

Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells

Cell Death Discovery, 2023
Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng, Jintao Dou, Yi Yang, Shaojie Sun, Ruiqi Chen, Zhijian Zhang, Huijun Wei, Jianhui Li, Zhihao Wu   +8 more
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Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, 2021
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, J. Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, S. Shi   +9 more
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Role of tumor microenvironment in cancer progression and therapeutic strategy

Cancer Medicine, 2023
Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its ...
Qingjing Wang, Xue-ting Shao, Yuxuan Zhang, Miaojin Zhu, F. X. Wang, Jianjian Mu, Jia-Xia li, H. Yao, Keda Chen   +8 more
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Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Cell Death and Disease, 2023
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.
Yan Zhao, Meili Shen, Liangqiang Wu, Haiqin Yang, Yixuan Yao, Qingbiao Yang, Jianshi Du, Linlin Liu, Yapeng Li, Yuansong Bai   +9 more
semanticscholar   +1 more source

Predicting the Progress of Tuberculosis by Inflammatory Response-Related Genes Based on Multiple Machine Learning Comprehensive Analysis

Journal of Immunology Research, 2023
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma, Peifei Peng, Zhihao Duan, Yifeng Fan, Xinzhi Li   +4 more
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Tumor-associated macrophages: an effective player of the tumor microenvironment

Frontiers in Immunology, 2023
Cancer progression is primarily caused by interactions between transformed cells and the components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) make up the majority of the invading immune components, which are further ...
Udit Basak, Tania Sarkar, S. Mukherjee, S. Chakraborty, A. Dutta, Saikat Dutta, Debadatta Nayak, Subhash Kaushik, Tanya Das, Gaurisankar Sa   +9 more
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KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li, Yiyu Wang, Yuan Mou, Hao Wu, Ye Qin   +4 more
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Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses

Nature Communications, 2023
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease remains
Taghreed Hirz, S. Mei, Hirak Sarkar, Y. Kfoury, Shulin Wu, B. M. Verhoeven, Alexander O. Subtelny, Dimitar V Zlatev, Matthew Wszolek, K. Salari, Evan Murray, Fei-Lin Chen, Evan Z. Macosko, Chin-Lee Wu, David T. Scadden, D. Dahl, Ninib Baryawno, P. Saylor, P. Kharchenko, D. Sykes   +19 more
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Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells

Cell Communication and Signaling, 2020
Background Metabolic reprogramming contributes significantly to tumor development and is tightly linked to drug resistance. The chemotherapeutic agent etoposide (VP-16) has been used clinically in the treatment of lung cancer but possess different ...
Qi Dong, Chenkang Zhou, Haodong Ren, Zhijian Zhang, Feng Cheng, Zhenkai Xiong, Chuantao Chen, Jianke Yang, Jiguang Gao, Yao Zhang, Lei Xu, Jian Fang, Yuxiang Cao, Huijun Wei, Zhihao Wu   +14 more
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Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1

Discover Oncology, 2022
Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li, Yaqi Kou, Xiaohan Zhang, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Shuang Yang   +12 more
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