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The tumor microenvironment [PDF]
Current Biology, 2020 A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix.
A. Rasheed, V. Koyyala
semanticscholar +4 more sources
Hypoxia and the Tumor Microenvironment [PDF]
Technology in Cancer Research & Treatment, 2021 Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response.
Yue Li, Longtao Zhao, Xiao-Feng Li
semanticscholar +5 more sources
Monocytes in the Tumor Microenvironment.
Annual Review of Pathology: Mechanisms of Disease, 2021 Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and ...
S. Ugel +3 more
semanticscholar +4 more sources
Understanding the tumor immune microenvironment (TIME) for effective therapy
Nature Medicine, 2018 Vincent Chan +2 more
exaly +2 more sources
Therapeutic Targeting of the Tumor Microenvironment.
Cancer Discovery, 2021 Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of ...
Leire Bejarano +2 more
semanticscholar +1 more source
Cell Death Discovery, 2023 Ferroptosis is a newly defined non-apoptotic programmed cell death resulting from the accumulation of lipid peroxides. Whether ferroptosis plays any role in chemotherapy remains to be established.
Feng Cheng +8 more
doaj +1 more source
Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance
Molecular Oncology, EarlyView., 2023 Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela +2 more
wiley +1 more source
Journal of Immunology Research, 2023 Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of the global population and is considered one of the most lethal infectious diseases worldwide.
Shuai Ma +4 more
doaj +1 more source
KDM1A Identified as a Potential Oncogenic Driver and Prognostic Biomarker via Multi-Omics Analysis
Canadian Journal of Infectious Diseases and Medical Microbiology, 2021 Background. Lysine-specific demethylase 1A (KDM1A) is a histone demethylation enzyme and a crucial epigenetic factor for multiple pathological pathways that mediate carcinogenesis and immunogenicity.
Lingyue Li +4 more
doaj +1 more source
Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
Discover Oncology, 2022 Lung adenocarcinoma is the major subtype of lung cancer, accounting for approximately 40% of lung cancers. During clinical treatment, the emergence of chemotherapy resistance seriously affects the effectiveness of treatment.
Jianjun Li +12 more
doaj +1 more source