Results 11 to 20 of about 3,438,472 (318)
Tumor microenvironment signaling and therapeutics in cancer progression
Cancer Communications, 2023 Tumor development and metastasis are facilitated by the complex interactions between cancer cells and their microenvironment, which comprises stromal cells and extracellular matrix (ECM) components, among other factors.
A. Goenka +7 more
semanticscholar +1 more source
Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma
Frontiers in Immunology, 2023 Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the third leading cause of tumor-related mortality worldwide. In recent years, the emergency of immune checkpoint inhibitor (ICI) has revolutionized the management of HCC ...
Chen Chen +3 more
semanticscholar +1 more source
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
Journal of Hematology & Oncology, 2023 Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways ...
Haoran Jin +6 more
semanticscholar +1 more source
Molecular Cancer, 2023 Despite centuries since the discovery and study of cancer, cancer is still a lethal and intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much attention as a pivotal component of the tumor microenvironment.
Hao Zhang +11 more
semanticscholar +1 more source
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin +5 more
doaj +1 more source
Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment
International Journal of Molecular Sciences, 2023 Several immune and immunocompetent cells, including dendritic cells, macrophages, adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the complex discipline of oncology. Cytotoxic innate and adaptive immune cells can
O. Habanjar +5 more
semanticscholar +1 more source
The emerging roles of MAPK-AMPK in ferroptosis regulatory network
Cell Communication and Signaling, 2023 Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang +4 more
doaj +1 more source
Macrophage Polarization States in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic ...
Ava J Boutilier, Sherine F. Elsawa
semanticscholar +1 more source
Firing up the cold tumors by targeting Vps34
OncoImmunology, 2020 Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji +4 more
doaj +1 more source
Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2
BMC Cancer, 2023 Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeutic approach ...
Ya-feng Lv +10 more
doaj +1 more source