Results 11 to 20 of about 3,534,255 (422)
The tumor microenvironment [PDF]
Current Biology, 2020 A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression.
M. Celeste Simon, Nicole M. Anderson
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Hypoxia and the Tumor Microenvironment [PDF]
Technology in Cancer Research & Treatment, 2021 Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of
Li Xiaofeng +4 more
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Molecular Cancer, 2021 Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao +9 more
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Role of tumor microenvironment in cancer progression and therapeutic strategy
Cancer Medicine, 2023 Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its ...
Qingjing Wang +8 more
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Medicina, 2019 Background and Objectives: The tumor microenvironment has been widely implicated in tumorigenesis because it harbors tumor cells that interact with surrounding cells through the circulatory and lymphatic systems to influence the development and progression of cancer.
Arneth, Borros +1 more
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Stromal cells in the tumor microenvironment: accomplices of tumor progression?
Cell Death and Disease, 2023 The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.
Yan Zhao +9 more
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Macrophage Polarization States in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic ...
Ava J Boutilier, Sherine F. Elsawa
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Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
Journal of Hematology & Oncology, 2023 Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain uncontrolled proliferation and survive in unfavorable environments that lack oxygen and nutrients, tumor cells undergo metabolic transformations to exploit various ways ...
Haoran Jin +6 more
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S-Nitrosylation in Tumor Microenvironment [PDF]
International Journal of Molecular Sciences, 2021 S-nitrosylation is a selective and reversible post-translational modification of protein thiols by nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These effects include the modulation of protein conformation, activity, stability, and protein-protein interactions.
Vandana Sharma +6 more
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Nature Communications, 2023 The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease remains
Taghreed Hirz +19 more
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