Results 21 to 30 of about 3,620,379 (402)

Macrophage Polarization States in the Tumor Microenvironment

International Journal of Molecular Sciences, 2021
The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic ...
Ava J Boutilier, Sherine F. Elsawa
semanticscholar   +1 more source

Screening of Molecular Markers of Cisplatin Resistance in Lung Adenocarcinoma and Functional Verification Based on TCGA Database

Zhongliu Fangzhi Yanjiu, 2022
Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin, HUANG Zixian, YOU Chengcheng, TAN Shunzi, HUANG Liming, HUANG Yiling   +5 more
doaj   +1 more source

Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses

Nature Communications, 2023
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease remains
Taghreed Hirz, S. Mei, Hirak Sarkar, Y. Kfoury, Shulin Wu, B. M. Verhoeven, Alexander O. Subtelny, Dimitar V Zlatev, Matthew Wszolek, K. Salari, Evan Murray, Fei-Lin Chen, Evan Z. Macosko, Chin-Lee Wu, David T. Scadden, D. Dahl, Ninib Baryawno, P. Saylor, P. V. Kharchenko, D. Sykes   +19 more
semanticscholar   +1 more source

The emerging roles of MAPK-AMPK in ferroptosis regulatory network

Cell Communication and Signaling, 2023
Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang, Xiao Tan, Jinping Zhang, Jiaping Wu, Hongjuan Shi   +4 more
doaj   +1 more source

Tumor-associated macrophages: an effective player of the tumor microenvironment

Frontiers in Immunology, 2023
Cancer progression is primarily caused by interactions between transformed cells and the components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) make up the majority of the invading immune components, which are further ...
Udit Basak, Tania Sarkar, S. Mukherjee, S. Chakraborty, A. Dutta, Saikat Dutta, Debadatta Nayak, Subhash Kaushik, Tanya Das, Gaurisankar Sa   +9 more
semanticscholar   +1 more source

Targeting the tumor microenvironment [PDF]

Frontiers in Bioscience, 2007
Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma.
Kenny, P.A., Lee, G.Y., Bissell, M.J.
openaire   +4 more sources

The Tumor Microenvironment and Cancer [PDF]

BioMed Research International, 2014
Tumors are now recognized as structures of multiple cell types. It is increasingly appreciated that as the cancer progresses, the surrounding microenvironment is activated in support, coevolving through continuous paracrine communication and supporting carcinogenesis.
Zhen Chen, Zhiqiang Meng, Lijun Jia, Rutao Cui   +3 more
openaire   +3 more sources

Monocytes in the Tumor Microenvironment

Annual Review of Pathology: Mechanisms of Disease, 2021
Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and local cues during tumor development.
Stefano Ugel, Stefania Canè, Francesco De Sanctis, Vincenzo Bronte   +3 more
openaire   +3 more sources

Telocytes in the Tumor Microenvironment

, 2021
There are several theories explaining the communication between cells in the context of tumor development. Over the years, interactions between normal and transformed cells have been observed. Generally, all types of cells make equal contributions to the formation of the tumor microenvironment - a location of primary oncogenesis.
Aleksandrovych, Veronika, Gil, Krzysztof
openaire   +4 more sources

The brain tumor microenvironment [PDF]

Glia, 2011
AbstractHigh‐grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell‐like capacity. The stem‐like cells may be the cells of origin for tumor relapse.
Eric C. Holland, Richard J. Gilbertson, Rainer Glass, Helmut Kettenmann, Nikki Charles   +4 more
openaire   +4 more sources