Results 21 to 30 of about 3,327,980 (264)

Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma

Frontiers in Immunology, 2023
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the third leading cause of tumor-related mortality worldwide. In recent years, the emergency of immune checkpoint inhibitor (ICI) has revolutionized the management of HCC ...
Chen Chen, Zehua Wang, Y. Ding, Yanru Qin   +3 more
semanticscholar   +1 more source

Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment

International Journal of Molecular Sciences, 2023
Several immune and immunocompetent cells, including dendritic cells, macrophages, adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the complex discipline of oncology. Cytotoxic innate and adaptive immune cells can
O. Habanjar, R. Bingula, C. Decombat, M. Diab‐Assaf, F. Caldefie-Chézet, L. Delort   +5 more
semanticscholar   +1 more source

The emerging roles of MAPK-AMPK in ferroptosis regulatory network

Cell Communication and Signaling, 2023
Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang, Xiao Tan, Jinping Zhang, Jiaping Wu, Hongjuan Shi   +4 more
doaj   +1 more source

Targeting the tumor microenvironment [PDF]

Frontiers in Bioscience, 2007
Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma.
Kenny, P.A., Lee, G.Y., Bissell, M.J.
openaire   +4 more sources

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Journal of Hematology & Oncology, 2022
Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids.
Mahshid Deldar Abad Paskeh, M. Entezari, Sepideh Mirzaei, Amirhossein Zabolian, Hossein Saleki, Mohamad Javad Naghdi, S. Sabet, M. Khoshbakht, M. Hashemi, K. Hushmandi, G. Sethi, A. Zarrabi, A. Kumar, S. C. Tan, M. Papadakis, A. Alexiou, Md. Asiful Islam, E. Mostafavi, M. Ashrafizadeh   +18 more
semanticscholar   +1 more source

The Tumor Microenvironment and Cancer [PDF]

BioMed Research International, 2014
Tumors are now recognized as structures of multiple cell types. It is increasingly appreciated that as the cancer progresses, the surrounding microenvironment is activated in support, coevolving through continuous paracrine communication and supporting carcinogenesis.
Zhen Chen, Zhiqiang Meng, Lijun Jia, Rutao Cui   +3 more
openaire   +3 more sources

Monocytes in the Tumor Microenvironment

Annual Review of Pathology: Mechanisms of Disease, 2021
Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and local cues during tumor development.
Stefano Ugel, Stefania Canè, Francesco De Sanctis, Vincenzo Bronte   +3 more
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Tumor microenvironment complexity and therapeutic implications at a glance

Cell Communication and Signaling, 2020
The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to ...
Roghayyeh Baghban, L. Roshangar, Rana Jahanban-Esfahlan, K. Seidi, Abbas Ebrahimi-kalan, M. Jaymand, S. Kolahian, Tahereh Javaheri, Peyman Zare   +8 more
semanticscholar   +1 more source

The brain tumor microenvironment [PDF]

Glia, 2011
AbstractHigh‐grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell‐like capacity. The stem‐like cells may be the cells of origin for tumor relapse.
Eric C. Holland, Richard J. Gilbertson, Rainer Glass, Helmut Kettenmann, Nikki Charles   +4 more
openaire   +4 more sources

Tumor microenvironment antigens [PDF]

Seminars in Immunopathology, 2022
AbstractThe identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. Traditionally, tumor-associated antigens (TAAs) are considered relatively restricted to tumor cells (i.e., overexpressed proteins in tumor cells), whereas tumor-specific antigens (TSAs) are considered unique to tumor cells ...
openaire   +3 more sources