Results 21 to 30 of about 3,552,325 (402)
Zhongliu Fangzhi Yanjiu, 2022 Objective To explore the related genes that play a key regulatory role in cisplatin resistance in lung adenocarcinoma. Methods Bioinformatics methods were used to download the differentially-expressed genes between cisplatin sensitive group and drug ...
WANG Lin +5 more
doaj +1 more source
Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma
Frontiers in Immunology, 2023 Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is the third leading cause of tumor-related mortality worldwide. In recent years, the emergency of immune checkpoint inhibitor (ICI) has revolutionized the management of HCC ...
Chen Chen +3 more
semanticscholar +1 more source
The emerging roles of MAPK-AMPK in ferroptosis regulatory network
Cell Communication and Signaling, 2023 Ferroptosis, a newform of programmed cell death, driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes and is extremely dependent on iron ions, which is differs characteristics from traditional cell ...
Xinyue Wang +4 more
doaj +1 more source
Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment
International Journal of Molecular Sciences, 2023 Several immune and immunocompetent cells, including dendritic cells, macrophages, adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the complex discipline of oncology. Cytotoxic innate and adaptive immune cells can
O. Habanjar +5 more
semanticscholar +1 more source
Targeting the tumor microenvironment [PDF]
Frontiers in Bioscience, 2007 Despite some notable successes cancer remains, for the most part, a seemingly intractable problem. There is, however, a growing appreciation that targeting the tumor epithelium in isolation is not sufficient as there is an intricate mutually sustaining synergy between the tumor epithelial cells and their surrounding stroma.
Kenny, P.A., Lee, G.Y., Bissell, M.J.
openaire +4 more sources
The Tumor Microenvironment and Cancer [PDF]
BioMed Research International, 2014 Tumors are now recognized as structures of multiple cell types. It is increasingly appreciated that as the cancer progresses, the surrounding microenvironment is activated in support, coevolving through continuous paracrine communication and supporting carcinogenesis.
Zhen Chen +3 more
openaire +3 more sources
Monocytes in the Tumor Microenvironment
Annual Review of Pathology: Mechanisms of Disease, 2021 Immunotherapy has revolutionized cancer treatment over the past decade. Nonetheless, prolonged survival is limited to relatively few patients. Cancers enforce a multifaceted immune-suppressive network whose nature is progressively shaped by systemic and local cues during tumor development.
Stefano Ugel +3 more
openaire +3 more sources
Tumor microenvironment complexity and therapeutic implications at a glance
Cell Communication and Signaling, 2020 The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to ...
Roghayyeh Baghban +8 more
semanticscholar +1 more source
Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Journal of Hematology & Oncology, 2022 Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids.
Mahshid Deldar Abad Paskeh +18 more
semanticscholar +1 more source
Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells [PDF]
, 2016 Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional programs. Using a conditional knockout mouse, we find that Satb1 is required for normal differentiation of conventional dendritic cells (DCs).
Allegrezza, Michael J. +14 more
core +1 more source