Results 31 to 40 of about 3,534,255 (422)

Tumor microenvironment complexity and therapeutic implications at a glance

Cell Communication and Signaling, 2020
The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to ...
Roghayyeh Baghban, L. Roshangar, Rana Jahanban-Esfahlan, K. Seidi, Abbas Ebrahimi-kalan, M. Jaymand, S. Kolahian, Tahereh Javaheri, Peyman Zare   +8 more
semanticscholar   +1 more source

Satb1 overexpression drives tumor-promoting activities in cancer-associated dendritic cells [PDF]

, 2016
Special AT-rich sequence-binding protein 1 (Satb1) governs genome-wide transcriptional programs. Using a conditional knockout mouse, we find that Satb1 is required for normal differentiation of conventional dendritic cells (DCs).
Allegrezza, Michael J., Borowsky, Mark E., Brencicova, Eva, Conejo Garcia, José R., Kossenkov, Andrew V., Nguyen, Jenny M., Payne, Kyle K., Perales Puchal, Alfredo, Rabinovich, Gabriel Adrián, Rutkowski, Melanie R., Stephen, Tom L., Svoronos, Nikolaos, Tchou, Julia, Tesone, Amelia J., Wickramasinghe, Jayamanna   +14 more
core   +1 more source

The brain tumor microenvironment [PDF]

Glia, 2011
AbstractHigh‐grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell‐like capacity. The stem‐like cells may be the cells of origin for tumor relapse.
Eric C. Holland, Richard J. Gilbertson, Rainer Glass, Helmut Kettenmann, Nikki Charles   +4 more
openaire   +4 more sources

Cancer prevention and therapy through the modulation of the tumor microenvironment [PDF]

, 2015
Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale ...
Amedei, Amedeo, Aquilano, Katia, Azmi, Asfar S., Benencia, Fabian, Bhakta, Dipita, Bilsland, Alan, Boosani, Chandra S., Casey, Stephanie C., Chen, Sophie, Ciriolo, Maria Rosa, Crawford, Sarah, Felsher, Dean W., Fujii, Hiromasa, Georgakilas, Alexandros G., Guha, Gunjan, Halicka, Dorota, Helferich, William G., Heneberg, Petr, Honoki, Kanya, Keith, W. Nicol, Kerkar, Sid P., Mohammed, Sulma I., Niccolai, Elena, Nowsheen, Somaira, Samadi, Abbas, Singh, Neetu, Talib, Wamidh H., Vasantha Rupasinghe, H.P., Venkateswaran, Vasundara, Whelan, Richard L., Yang, Xujuan   +30 more
core   +1 more source

Firing up the cold tumors by targeting Vps34

OncoImmunology, 2020
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem, Muhammad Zaeem Noman   +4 more
doaj   +1 more source

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer [PDF]

, 2015
Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic ...
Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James H., Powell, Arfon G., Richards, Colin H., Roxburgh, Campbell S.D.   +6 more
core   +1 more source

Tumor microenvironment and progression [PDF]

Journal of Surgical Oncology, 2011
AbstractTumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor‐A (VEGF‐A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis.
Dvorak, Harold F, Weaver, Valerie M, Tlsty, Thea D, Bergers, Gabriele   +3 more
openaire   +5 more sources

Tumor microenvironment antigens [PDF]

Seminars in Immunopathology, 2022
AbstractThe identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. Traditionally, tumor-associated antigens (TAAs) are considered relatively restricted to tumor cells (i.e., overexpressed proteins in tumor cells), whereas tumor-specific antigens (TSAs) are considered unique to tumor cells ...
openaire   +3 more sources

Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2

BMC Cancer, 2023
Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeutic approach ...
Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang   +10 more
doaj   +1 more source

The Tumor Microenvironment Innately Modulates Cancer Progression.

Cancer Research, 2019
Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors.
D. Hinshaw, L. Shevde
semanticscholar   +1 more source