Results 31 to 40 of about 3,438,472 (318)

Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance.

Annual Review of Pathology, 2022
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance.
M. Sherman, G. Beatty
semanticscholar   +1 more source

Fully murine CD105-targeted CAR-T cells provide an immunocompetent model for CAR-T cell biology

OncoImmunology, 2022
The modeling of chimeric antigen receptor (CAR) T cell therapies has been mostly focused on immunodeficient models. However, there are many advantages in studying CAR-T cell biology in an immunocompetent setting. We generated a fully murine CAR targeting
Konstantinos Lontos, Yiyang Wang, Mason Colbert, Alok Kumar, Supriya Joshi, Mary Philbin, Yupeng Wang, Andrew Frisch, Jason Lohmueller, Dayana B. Rivadeneira, Greg M. Delgoffe   +10 more
doaj   +1 more source

Anti-S100A4 Antibody Suppresses Metastasis Formation by Blocking Stroma Cell Invasion

Neoplasia: An International Journal for Oncology Research, 2012
The small Ca-binding protein, S100A4, has a well-established metastasis-promoting activity. Moreover, its expression is tightly correlated with poor prognosis in patients with numerous types of cancer.
Jörg Klingelhöfer, Birgitte Grum-Schwensen, Mette K. Beck, Rikke Stagaard Petersen Knudsen, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian   +6 more
doaj   +1 more source

USP51/PD‐L1/ITGB1‐deployed juxtacrine interaction plays a cell‐intrinsic role in promoting chemoresistant phenotypes in non‐small cell lung cancer

Cancer Communications, 2023
Background Programmed death ligand 1 (PD‐L1) has been demonstrated to facilitate tumor progression and therapeutic resistance in an immune‐independent manner.
Jianjun Li, Xuechun Xiao, Yang Ou, Lixia Cao, Min Guo, Chunchun Qi, Zhaoyang Wang, Yuxin Liu, Qiuying Shuai, Hang Wang, Peiqing Sun, Yi Shi, Guang Yang, Shuang Yang   +13 more
doaj   +1 more source

Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1

Nature Communications, 2020
The transcription factor Zeb1 is known to promote tumorigenesis and stemness in breast cancer. Here the authors show that tumor endothelial Jagged1 induces activation of Notch1 signaling and increases Zeb1 expression in neighboring breast cancer stem ...
Huimin Jiang, Chen Zhou, Zhen Zhang, Qiong Wang, Huimin Wei, Wen Shi, Jianjun Li, Zhaoyang Wang, Yang Ou, Wenhao Wang, Hang Wang, Quansheng Zhang, Wei Sun, Peiqing Sun, Shuang Yang   +14 more
doaj   +1 more source

Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
doaj   +1 more source

Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance

International Journal on Biological Sciences, 2022
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic failure.
Aiping Zhang, Kai Miao, Heng Sun, Chuxia Deng   +3 more
semanticscholar   +1 more source

B Cell Function in the Tumor Microenvironment.

Annual Review of Immunology, 2022
The tumor microenvironment (TME) is a heterogeneous, complex organization composed of tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and innate and adaptive immune cells.
Stephanie M Downs-Canner, J. Meier, B. Vincent, J. Serody   +3 more
semanticscholar   +1 more source

GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression

Cancer Medicine, 2013
Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk, Archana K. Yanamandra, Nina Linde, Alice Meides, Sofia Depner, Margareta M. Mueller   +5 more
doaj   +1 more source

Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies

Frontiers in Pharmacology, 2021
The Syrian golden hamster (Mesocricetus auratus) has recently been demonstrated as a clinically relevant animal model for SARS-CoV-2 infection. However, lack of knowledge about the tissue-specific expression pattern of various proteins in these animals ...
Voddu Suresh, Voddu Suresh, Deepti Parida, Deepti Parida, Aliva P. Minz, Aliva P. Minz, Manisha Sethi, Manisha Sethi, Bhabani S. Sahoo, Shantibhusan Senapati   +9 more
doaj   +1 more source