Results 31 to 40 of about 3,561,070 (402)

Telocytes in the Tumor Microenvironment

, 2021
There are several theories explaining the communication between cells in the context of tumor development. Over the years, interactions between normal and transformed cells have been observed. Generally, all types of cells make equal contributions to the formation of the tumor microenvironment - a location of primary oncogenesis.
Aleksandrovych, Veronika, Gil, Krzysztof
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The brain tumor microenvironment [PDF]

Glia, 2011
AbstractHigh‐grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell‐like capacity. The stem‐like cells may be the cells of origin for tumor relapse.
Eric C. Holland, Richard J. Gilbertson, Rainer Glass, Helmut Kettenmann, Nikki Charles   +4 more
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Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
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Tumor microenvironment and progression [PDF]

Journal of Surgical Oncology, 2011
AbstractTumor blood vessels are heterogeneous, of at least six distinct types, are induced primarily by vascular endothelial growth factor‐A (VEGF‐A), and provide a potentially useful therapeutic target. Breast cancer is characterized by changes in the microenvironment that result in altered tensional homeostasis.
Dvorak, Harold F, Weaver, Valerie M, Tlsty, Thea D, Bergers, Gabriele   +3 more
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Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model [PDF]

, 2012
Decorin, a member of the small leucine-rich proteoglycan gene family, exists and functions wholly within the tumor microenvironment to suppress tumorigenesis by directly targeting and antagonizing multiple receptor tyrosine kinases, such as the EGFR and ...
Buraschi, Simone, Evans, Barry, Iniguez, Leonardo A., Iozzo, Renato V., Neill, Thomas, Owens, Rick T., Peiper, Stephen C., Purkins, George, Schäfer, Liliana, Vadigepalli, Rajanikanth, Wang, Zi-Xuan   +10 more
core   +7 more sources

Firing up the cold tumors by targeting Vps34

OncoImmunology, 2020
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration.
Bassam Janji, Meriem Hasmim, Santiago Parpal, Guy Berchem, Muhammad Zaeem Noman   +4 more
doaj   +1 more source

Tumor microenvironment complexity and therapeutic implications at a glance

Cell Communication and Signaling, 2020
The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to ...
Roghayyeh Baghban, L. Roshangar, Rana Jahanban-Esfahlan, K. Seidi, Abbas Ebrahimi-kalan, M. Jaymand, S. Kolahian, Tahereh Javaheri, Peyman Zare   +8 more
semanticscholar   +1 more source

Emerging role of exosomes in cancer progression and tumor microenvironment remodeling

Journal of Hematology & Oncology, 2022
Cancer is one of the leading causes of death worldwide, and the factors responsible for its progression need to be elucidated. Exosomes are structures with an average size of 100 nm that can transport proteins, lipids, and nucleic acids.
Mahshid Deldar Abad Paskeh, M. Entezari, Sepideh Mirzaei, Amirhossein Zabolian, Hossein Saleki, Mohamad Javad Naghdi, S. Sabet, M. Khoshbakht, M. Hashemi, K. Hushmandi, G. Sethi, A. Zarrabi, A. Kumar, S. C. Tan, M. Papadakis, A. Alexiou, Md. Asiful Islam, E. Mostafavi, M. Ashrafizadeh   +18 more
semanticscholar   +1 more source

Identification of Topological Features in Renal Tumor Microenvironment Associated with Patient Survival [PDF]

, 2017
Motivation As a highly heterogeneous disease, the progression of tumor is not only achieved by unlimited growth of the tumor cells, but also supported, stimulated, and nurtured by the microenvironment around it.
Cheng, Jun, Feng, Qianjin, Huang, Kun, Mo, Xiaokui, Parwani, Anil, Wang, Xusheng   +5 more
core   +1 more source

Tumor microenvironment antigens [PDF]

Seminars in Immunopathology, 2022
AbstractThe identification and characterization of tumor antigens are central objectives in developing anti-cancer immunotherapy. Traditionally, tumor-associated antigens (TAAs) are considered relatively restricted to tumor cells (i.e., overexpressed proteins in tumor cells), whereas tumor-specific antigens (TSAs) are considered unique to tumor cells ...
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