Results 41 to 50 of about 3,438,472 (318)

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Molecular Cancer, 2020
The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration remain unknown. We comprehensively evaluated
Bo Zhang, Qiong Wu, Ben Li, Defeng Wang, Lei Wang, Y. Zhou   +5 more
semanticscholar   +1 more source

Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells

Cancer Biology & Medicine
Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu   +10 more
doaj   +1 more source

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology
Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds.
Qiang Lu, Dongquan Kou, Shenghan Lou, M. Ashrafizadeh, A. Aref, Israel Cañadas, Yu Tian, Xiaojia Niu, Yuzhuo Wang, Pedram Torabian, Lingzhi Wang, Gautam Sethi, Vinay Tergaonkar, Franklin Tay, Zhennan Yuan, Peng Han   +15 more
semanticscholar   +1 more source

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

Cancer Cell International, 2021
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor.
Asieh Emami Nejad, Simin Najafgholian, A. Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, R. Nedaeinia, S. Haghjooy Javanmard, Marjan Taherian, M. Ahmadlou, R. Salehi, Bahman Sadeghi, M. Manian   +12 more
semanticscholar   +1 more source

Identification of Circular RNAs Associated With Chemoresistance in Colorectal Cancer

Frontiers in Genetics, 2021
Chemoresistance is a major clinical obstacle for the treatment of colorectal cancer (CRC). Circular RNAs (circRNAs) are a new type of non-coding RNA that participated in the development of chemoresistance. However, the profiles and effects of circRNAs in
Fei Yao, Xiaochen Xiang, Chuanren Zhou, Qiyou Huang, Xiaoying Huang, Zhufu Xie, Qiang Wang, Qingming Wu, Qingming Wu   +8 more
doaj   +1 more source

Immunologic tumor microenvironment modulators for turning cold tumors hot

Cancer Communications
Tumors can be classified into distinct immunophenotypes based on the presence and arrangement of cytotoxic immune cells within the tumor microenvironment (TME).
Gholam-Reza Khosravi, Samaneh Mostafavi, Sanaz Bastan, Narges Ebrahimi, Roya Safari Gharibvand, N. Eskandari   +5 more
semanticscholar   +1 more source

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

Cancers, 2021
Simple Summary Metastasis, the process by which cancer cells escape primary tumor site and colonize distant organs, is responsible for most cancer-related deaths.
C. Neophytou, Myrofora Panagi, T. Stylianopoulos, P. Papageorgis   +3 more
semanticscholar   +1 more source

Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages

Theranostics, 2021
Macrophages phagocytize pathogens to initiate innate immunity and products from the tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated macrophage (TAM)-mediated immune responses results in immune suppression.
Degao Chen, Xiaomei Zhang, Zhongjun Li, B. Zhu   +3 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment

bioRxiv, 2020
Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows remarkable efficacy in a variety of cancer types. However, only a minority of patients respond to treatment due to the stochastic heterogeneity of tumor microenvironment ...
Dongqing Sun, Jin Wang, Ya Han, Xin Dong, Jun Ge, Rongbin Zheng, Xiaoying Shi, Binbin Wang, Ziyi Li, Pengfei Ren, Liangdong Sun, Yilv Yan, Peng Zhang, Fan Zhang, Taiwen Li, Chenfei Wang   +15 more
semanticscholar   +1 more source