Results 41 to 50 of about 3,620,379 (402)
The Tumor Microenvironment Innately Modulates Cancer Progression.
Cancer Research, 2019 Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors.
D. Hinshaw, L. Shevde
semanticscholar +1 more source
Tumor microenvironment complexity and therapeutic implications at a glance
Cell Communication and Signaling, 2020 The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to ...
Roghayyeh Baghban +8 more
semanticscholar +1 more source
The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment
Frontiers in Pharmacology, 2022 Recently, in the field of cancer treatment, the paradigm has changed to immunotherapy that activates the immune system to induce cancer attacks. Among them, immune checkpoint inhibitors (ICI) are attracting attention as excellent and continuous clinical ...
Seong Keun Kim, S. Cho
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Hepatology Communications, 2020 Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen +10 more
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Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination [PDF]
International Journal of Ophthalmology, 2016 AIM: To investigate the role of tumor necrosis factor-alpha (TNF-α) in zebrafish retinal development and myelination. METHODS: Morpholino oligonucleotides (MO), which are complementary to the translation start site of the wild-type embryonic zebrafish ...
Xu-Dan Lei +5 more
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Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance.
Annual Review of Pathology, 2022 Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance.
M. Sherman, G. Beatty
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Role of Rip2 in development of tumor-infiltrating MDSCs and bladder cancer metastasis. [PDF]
, 2014 Tumor invasion and metastases represent a complex series of molecular events that portends a poor prognosis. The contribution of inflammatory pathways mediating this process is not well understood. Nod-like receptors (NLRs) of innate immunity function as
Chin, Arnold I, Zhang, Hanwei
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Journal of Nanobiotechnology, 2023 Macrophage polarization determines the production of cytokines that fuel the initiation and evolution of rheumatoid arthritis (RA). Thus, modulation of macrophage polarization might represent a potential therapeutic strategy for RA.
Ni Yang +12 more
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Journal for ImmunoTherapy of Cancer, 2023 Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells.
Benjamin Boyerinas +12 more
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Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]
, 2017 The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert +3 more
core +2 more sources