Results 41 to 50 of about 3,561,070 (402)

Gene delivery to breast cancer by incorporated EpCAM targeted DARPins into AAV2

BMC Cancer, 2023
Objective The aim of this study is to evaluate an AAV vector that can selectively target breast cancer cells and to investigate its specificity and anti-tumor effects on breast cancer cells both in vitro and in vivo, offering a new therapeutic approach ...
Ya-feng Lv, Hao Zhang, Zhi Cui, Cui-jiao Ma, Yu-ling Li, Hua Lu, Hong-yan Wu, Jian-lin Yang, Chun-yu Cao, Wen-zheng Sun, Xiao-fei Huang   +10 more
doaj   +1 more source

Lipid-loaded macrophages as new therapeutic target in cancer

Journal for ImmunoTherapy of Cancer, 2022
Macrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections.
Ping-Chih Ho, Giulia Marelli, Nicolò Morina, Federica Portale, Marta Pandini, Marta Iovino, Giusy Di Conza, Diletta Di Mitri   +7 more
doaj   +1 more source

Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer

Cell Death and Disease, 2022
Aerobic glycolysis (the Warburg effect) has been demonstrated to facilitate tumor progression by producing lactate, which has important roles as a proinflammatory and immunosuppressive mediator.
Huimin Jiang, Huimin Wei, Hang Wang, Zhaoyang Wang, Jianjun Li, Yang Ou, Xuechun Xiao, Wenhao Wang, Antao Chang, Wei Sun, Li Zhao, Shuang Yang   +11 more
doaj   +1 more source

The Tumor Microenvironment Innately Modulates Cancer Progression.

Cancer Research, 2019
Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors.
D. Hinshaw, L. Shevde
semanticscholar   +1 more source

Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance.

Annual Review of Pathology, 2022
Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance.
M. Sherman, G. Beatty
semanticscholar   +1 more source

Role of tumor necrosis factor-alpha in zebrafish retinal neurogenesis and myelination [PDF]

International Journal of Ophthalmology, 2016
AIM: To investigate the role of tumor necrosis factor-alpha (TNF-α) in zebrafish retinal development and myelination. METHODS: Morpholino oligonucleotides (MO), which are complementary to the translation start site of the wild-type embryonic zebrafish ...
Xu-Dan Lei, Yan Sun, Shi-Jiao Cai, Yang-Wu Fang, Jian-Lin Cui, Yu-Hao Li   +5 more
doaj   +1 more source

Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2

Hepatology Communications, 2020
Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood.
Yunru Chen, Qing Li, Kangsheng Tu, Yuanguo Wang, Xianghu Wang, Dandan Liu, Chen Chen, Donglian Liu, Rendong Yang, Wei Qiu, Ningling Kang   +10 more
doaj   +1 more source

Peptide-anchored neutrophil membrane-coated biomimetic nanodrug for targeted treatment of rheumatoid arthritis

Journal of Nanobiotechnology, 2023
Macrophage polarization determines the production of cytokines that fuel the initiation and evolution of rheumatoid arthritis (RA). Thus, modulation of macrophage polarization might represent a potential therapeutic strategy for RA.
Ni Yang, Miaomiao Li, Ling Wu, Yinhong Song, Shi Yu, Yingying Wan, Wenjing Cheng, Baoye Yang, Xiaoqin Mou, Hong Yu, Jing Zheng, Xinzhi Li, Xiang Yu   +12 more
doaj   +1 more source

Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment [PDF]

, 2019
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit.
Pastor Loro, Ángel Manuel, Rodríguez Matarredona, Esperanza   +1 more
core   +1 more source

Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors

Journal for ImmunoTherapy of Cancer, 2023
Background Cellular immunotherapies for cancer represent a means by which a patient’s immune system can be augmented with high numbers of tumor-specific T cells.
Benjamin Boyerinas, Greg M Delgoffe, Yupeng Wang, Alok Kumar, Ashley V Menk, Konstantinos Lontos, Yiyang Wang, Jason Lohmueller, Supriya K Joshi, Andrew T Frisch, McLane J Watson, Rachel Cumberland, Esteban Carrizosa   +12 more
doaj   +1 more source