Results 61 to 70 of about 3,327,980 (264)

m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer

Molecular Cancer, 2020
The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration remain unknown. We comprehensively evaluated
Bo Zhang, Qiong Wu, Ben Li, Defeng Wang, Lei Wang, Y. Zhou   +5 more
semanticscholar   +1 more source

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology
Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in the clinical delivery of immunomodulatory compounds.
Qiang Lu, Dongquan Kou, Shenghan Lou, M. Ashrafizadeh, A. Aref, Israel Cañadas, Yu Tian, Xiaojia Niu, Yuzhuo Wang, Pedram Torabian, Lingzhi Wang, Gautam Sethi, Vinay Tergaonkar, Franklin Tay, Zhennan Yuan, Peng Han   +15 more
semanticscholar   +1 more source

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

Molecular Cancer, 2019
Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular expression program and lead to therapy resistance.
Xinming Jing, Fengming Yang, C. Shao, Ke Wei, M. Xie, H. Shen, Y. Shu   +6 more
semanticscholar   +1 more source

Tumor Microenvironment and Metabolism [PDF]

International Journal of Molecular Sciences, 2017
The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. [...]
openaire   +3 more sources

Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells

Cancer Biology & Medicine
Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Platinum-based chemotherapy is one of the main treatment options for patients with non-small cell lung cancer (NSCLC) but the effectiveness of chemotherapy is encumbered ...
Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu   +10 more
doaj   +1 more source

Identification of Circular RNAs Associated With Chemoresistance in Colorectal Cancer

Frontiers in Genetics, 2021
Chemoresistance is a major clinical obstacle for the treatment of colorectal cancer (CRC). Circular RNAs (circRNAs) are a new type of non-coding RNA that participated in the development of chemoresistance. However, the profiles and effects of circRNAs in
Fei Yao, Xiaochen Xiang, Chuanren Zhou, Qiyou Huang, Xiaoying Huang, Zhufu Xie, Qiang Wang, Qingming Wu, Qingming Wu   +8 more
doaj   +1 more source

Fibrocytes in the Tumor Microenvironment [PDF]

, 2020
Tumors have long been compared to chronic wounds that do not heal, since they share many of the same molecular and cellular processes. In normal wounds, healing processes lead to restoration of cellular architecture, while in malignant tumors, these healing processes become dysregulated and contribute to growth and invasion of neoplastic cells into the
Richard H. Gomer, Jason B. Fleming, David Roife   +2 more
openaire   +2 more sources

Ferroptosis and the tumor microenvironment. [PDF]

J Exp Clin Cancer Res
AbstractFerroptosis is a type of regulated cell death characterized by its non-apoptotic, iron-dependent and oxidative nature. Since its discovery in 2012, extensive research has demonstrated its pivotal roles in tumorigenesis, metastasis and cancer therapy.
Cui K, Wang K, Huang Z.
europepmc   +4 more sources

IRE1α‐XBP1s axis regulates SREBP1‐dependent MRP1 expression to promote chemoresistance in non‐small cell lung cancer cells

Thoracic Cancer
Background Inositol‐requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)‐resident transmembrane protein that senses ER stress and mediates an essential arm of the unfolded protein response (UPR).
Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu   +9 more
doaj   +1 more source

Functional and mechanistic studies reveal MAGEA3 as a pro-survival factor in pancreatic cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background In the era of personalized therapy, functional annotation of less frequent genetic aberrations will be instrumental in adapting effective therapeutic in clinic.
Biswajit Das, Shantibhusan Senapati
doaj   +1 more source