Results 61 to 70 of about 3,552,325 (402)
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan+12 more
doaj +1 more source
Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ” composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells and extracellular matrix (ECM).
Khalil Khalaf+5 more
semanticscholar +1 more source
Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows remarkable efficacy in a variety of cancer types. However, only a minority of patients respond to treatment due to the stochastic heterogeneity of tumor microenvironment ...
Dongqing Sun+15 more
semanticscholar +1 more source
B Cell Function in the Tumor Microenvironment.
The tumor microenvironment (TME) is a heterogeneous, complex organization composed of tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and innate and adaptive immune cells.
Stephanie M Downs-Canner+3 more
semanticscholar +1 more source
Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
The past decades have witnessed great progress in cancer immunotherapy, which has profoundly revolutionized oncology, whereas low patient response rates and potential immune‐related adverse events remain major clinical challenges.
Shao-jun Peng+3 more
semanticscholar +1 more source
Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer. [PDF]
Tumors adapt to an unfavorable microenvironment by controlling the balance between cell proliferation and cell motility, but the regulators of this process are largely unknown.
Ashani T. Weeraratna+17 more
core +2 more sources
The updated landscape of tumor microenvironment and drug repurposing
Accumulating evidence shows that cellular and acellular components in tumor microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and response to therapies.
Ming-zhu Jin, Wei-Lin Jin
semanticscholar +1 more source
Tumor heterogeneity reshapes the tumor microenvironment to influence drug resistance
Tumor heterogeneity is one of the hallmarks of cancer and a challenge in the field of oncology. Tumor heterogeneity is the main cause of drug resistance, leading to therapeutic failure.
Aiping Zhang+3 more
semanticscholar +1 more source
Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]
The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert+3 more
core +2 more sources
GM‐CSF enhances tumor invasion by elevated MMP‐2, ‐9, and ‐26 expression
Granulocyte–macrophage colony‐stimulating factor (GM‐CSF) promotes tumor progression in different tumor models in an autocrine and paracrine manner. However, at the same time GM‐CSF is used in cancer therapies to ameliorate neutropenia.
Claudia M. Gutschalk+5 more
doaj +1 more source