Results 11 to 20 of about 506,829 (351)
Frontiers in Pharmacology, 2023 Objective: Tumor necrosis factor alpha inhibitors (TNFi) have shown substantial efficacy in alleviating and treating ankylosing spondylitis (AS). However, the heightened interest is accompanied by concerns over adverse events.
Haihuan Feng +7 more
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Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy
Cancers, 2021 Simple Summary Inflammation has been acknowledged as one of the causes of increased cancer risk. Among the pro-inflammatory mediators, tumor necrosis factor alpha (TNFα) has been identified as an important player in cancer progression and metastasis.
M. Mercogliano +4 more
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Neural Regeneration Research, 2022 Inflammatory processes and proinflammatory cytokines have a key role in the cellular processes of neurodegenerative diseases and are linked to the pathogenesis of functional and mental health disorders.
Fatemeh Zahedipour +4 more
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PLoS Biology, 2020 Tumor necrosis factor-alpha (TNF-α) plays an important pathogenic role in cardiac hypertrophy and heart failure (HF); however, anti-TNF is paradoxically negative in clinical trials and even worsens HF, indicating a possible protective role of TNF-α in HF.
Kun Miao +9 more
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Tumor Necrosis Factor-Alpha and Age-Related Pathologies
Архивъ внутренней медицины, 2020 Modern concepts about the «inflammaging» and the role of subclinical inflammation in various age-associated pathology are described in the review. Particular attention is paid to the tumor necrosis factor-α, a key cytokine that plays an important role in
S. V. Topolyanskaya
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Proceedings of the National Academy of Sciences of the United States of America, 1993 Catherine S. Tripp +2 more
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Epigenetic Regulation of Tumor Necrosis Factor Alpha [PDF]
Molecular and Cellular Biology, 2007 Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message turnover, message splicing, translation, and protein cleavage from the cell surface all being independently ...
K E, Sullivan +6 more
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Journal of Experimental Medicine, 1994 Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic ...
F. Sallusto, A. Lanzavecchia
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Tumor Necrosis Factor Alpha-Mediated Asthma? [PDF]
International Archives of Allergy and Immunology, 2012 Thus the pathophysiology of allergic asthma is traditionally explained by mast celland/or Th2 cell-mediated airway inflammation, which is a manifestation of the acquired immune response. On the other hand, recent studies have identified various other important molecules associated with phenotypes of asthma, including tumor necrosis factor (TNF)[2, 3] ,
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Alopecia secondary to anti-tumor necrosis factor-alpha therapy [PDF]
Anais Brasileiros de Dermatologia, 2015 Biologic drugs represent a substantial progress in the treatment of chronic inflammatory immunologic diseases. However, its crescent use has revealed seldom reported or unknown adverse reactions, mainly associated with anti-tumor necrosis factor (anti ...
Lara Beatriz Prata Ribeiro +5 more
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