Results 31 to 40 of about 506,829 (351)

Single-cell multi-omics reveals the TNF-α activation threshold for Classical Monocytes by studying healthy donors and rheumatoid arthritis patients

Frontiers in Immunology
IntroductionTumor Necrosis Factor Alpha is a known pro-inflammatory cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Anti-cytokine therapies targeting Tumor Necrosis Factor Alpha have greatly succeeded in treating rheumatoid ...
Roman Perik-Zavodskii, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Saleh Alrhmoun, Saleh Alrhmoun, Julia Lopatnikova, Julia Lopatnikova, Alina Alshevskaya, Julia Zhukova, Julia Zhukova, Julia Shevchenko, Julia Shevchenko, Nadezhda Shkaruba, Natalia Sivitskaya, Shakir Suleimanov, Elizaveta Sheveleva, Kirill Nazarov, Fedor Kireev, Fedor Kireev, Alexey Sizikov, Elena Golikova, Sergey Sennikov, Sergey Sennikov   +22 more
doaj   +1 more source

Glaucomatous neurodegeneration: An eye on tumor necrosis factor-alpha

Indian Journal of Ophthalmology, 2012
Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively
Renu Agarwal, Puneet Agarwal
doaj   +1 more source

Expression of tumor necrosis factor-alpha–converting enzyme and tumor necrosis factor-alpha in human myocarditis

Journal of the American College of Cardiology, 2000
We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis.Tumor necrosis factor-alpha-converting enzyme, which has recently been identified as belonging to the family of metalloproteinase disintegrin proteins, is responsible for the conversion of TNF-alpha ...
Satoh, Mamoru, Nakamura, Motoyuki, Satoh, Hidetoshi, Saitoh, Hidenori, Segawa, Ikuo, Hiramori, Katsuhiko   +5 more
openaire   +2 more sources

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes

Journal of Experimental Medicine, 1991
Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are triggered with lipopolysaccharide and other agonists in culture. 40% inhibition occurs at the clinically achievable dose of the
E. Sampaio, E. Sarno, R. Galilly, Z. Cohn, G. Kaplan   +4 more
semanticscholar   +1 more source

Tumor necrosis factor-alpha in patients with alopecia areata

Indian Journal of Dermatology, 2011
Background : Alopecia areata (AA) is a common form of localized, nonscarring hair loss. It is characterized by the loss of hair in patches, total loss of scalp hair (alopecia totalis, AT), or total loss of body hair (alopecia universalis, AU).
Emina Kasumagic-Halilovic, Asja Prohic, Semra Cavaljuga   +2 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Segmental vitiligo after infliximab use for rheumatoid arthritis - A case report [PDF]

Anais Brasileiros de Dermatologia, 2014
The tumor necrosis factor alpha is a cytokine related to immune and inflammatory processes by acting on different parts of the body. It is secreted by several cell types including macrophages, lymphocytes, monocytes, neutrophils, dendritic cells, among ...
Clarissa Luiza Dalla Bernardina Carvalho, Luciena Cegatto Martins Ortigosa   +1 more
doaj   +1 more source

Tumor Necrosis Factor Alpha in Amyotrophic Lateral Sclerosis: Friend or Foe?

Cells, 2021
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a massive neuroinflammatory reaction, which plays a key role in the progression of the disease.
Giulia Guidotti, Chiara Scarlata, Liliana Brambilla, Daniela Rossi   +3 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source