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Disulfidptosis in tumor progression [PDF]

Cell Death Discovery
Disulfidptosis, a regulated cell death modality driven by the cystine transporter solute carrier family 7 member 11 (SLC7A11), is characterized by actin cytoskeleton collapse under glucose starvation.
Senlin Wan, Changming Liang, Chengwei Wu, Song Wang, Jiawei Wang, Lishuai Xu, Xu Zhang, Yinfen Hou, Yabin Xia, Li Xu, Xiaoxu Huang   +10 more
doaj   +4 more sources

RNA-binding proteins in tumor progression

Journal of Hematology & Oncology, 2020
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA ...
Hai Qin, Haiwei Ni, Yichen Liu, Yaqin Yuan, Tao Xi, Xiaoman Li, Lufeng Zheng   +6 more
doaj   +2 more sources

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

Frontiers in Oncology, 2020
The tumor microenvironment (TME) is composed of various cell types embedded in an altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also regulates cell–cell or cell–matrix cross-talks.
Sylvie Brassart-Pasco, Sylvie Brassart-Pasco, Stéphane Brézillon, Stéphane Brézillon, Bertrand Brassart, Bertrand Brassart, Laurent Ramont, Laurent Ramont, Laurent Ramont, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Jean-Baptiste Oudart, Jean Claude Monboisse, Jean Claude Monboisse, Jean Claude Monboisse   +14 more
doaj   +2 more sources

Tumor-associated macrophages: an accomplice in solid tumor progression

Journal of Biomedical Science, 2019
In many solid tumor types, tumor-associated macrophages (TAMs) are important components of the tumor microenvironment (TME). Moreover, TAMs infiltration is strongly associated with poor survival in solid tumor patients.
Yibing Chen, Yucen Song, Wei Du, Longlong Gong, Haocai Chang, Zhengzhi Zou   +5 more
doaj   +2 more sources

SPP1 regulates tumor progression through modulation of signaling pathways and the tumor microenvironment [PDF]

Discover Oncology
Secreted Phosphoprotein 1 (SPP1), also known as Osteopontin (OPN), is a phosphorylated glycoprotein that plays a crucial role in regulating various cellular functions and immune responses.
Yang Feng, Xuanbo Shao, Zhuo-Fan Xu, Penghao Liu, Huantong Wu, Yuanchen Cheng, Maoyang Qi, Hongfeng Meng, Boyan Zhang, Feng-zeng Jian, Zan Chen, Wanru Duan   +11 more
doaj   +2 more sources

Inflammation and tumor progression: signaling pathways and targeted intervention

Signal Transduction and Targeted Therapy, 2021
Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes.
Huakan Zhao, Lei Wu, Guifang Yan, Yu Chen, Mingyue Zhou, Yongzhong Wu, Yongsheng Li   +6 more
semanticscholar   +1 more source

A Mammary Organoid Model to Study Branching Morphogenesis

Frontiers in Physiology, 2022
Branching morphogenesis is the process that gives rise to branched structures in several organs, such as the lung, the kidney, and the mammary gland. Although morphologically well described, the exact mechanisms driving branch elongation and bifurcation ...
Marika Caruso, Sjanie Huang, Larissa Mourao, Larissa Mourao, Colinda L. G. J. Scheele, Colinda L. G. J. Scheele   +5 more
doaj   +1 more source

A Label-Free Cell Sorting Approach to Highlight the Impact of Intratumoral Cellular Heterogeneity and Cancer Stem Cells on Response to Therapies

Cells, 2022
Cancer stem cells play a crucial role in tumor initiation, metastasis, and resistance to treatment. Cellular heterogeneity and plasticity complicate the isolation of cancer stem cells.
Céline Hervieu, Mireille Verdier, Elodie Barthout, Gaëlle Bégaud, Niki Christou, Magali Sage, Julie Pannequin, Serge Battu, Muriel Mathonnet   +8 more
doaj   +1 more source

Detection of Glycosylated Markers From Cancer Stem Cells With ColoSTEM Dx Kit for Earlier Prediction of Colon Cancer Aggressiveness

Frontiers in Oncology, 2022
Nowadays, colon cancer prognosis still difficult to predict, especially in the early stages. Recurrences remain elevated, even in the early stages after curative surgery.
Sabrina Blondy, Stéphanie Durand, Aurélie Lacroix, Niki Christou, Niki Christou, Charline Bouchaud, Maud Peyny, Serge Battu, Serge Battu, Alain Chauvanel, Alain Chauvanel, Vincent Carré, Marie-Odile Jauberteau, Marie-Odile Jauberteau, Fabrice Lalloué, Muriel Mathonnet, Muriel Mathonnet   +16 more
doaj   +1 more source

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Molecular Cancer, 2023
The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis. Anticancer treatments including adjuvant therapies and targeted therapies are effective in eliminating ...
Zhennan Yuan, Yingpu Li, Sifan Zhang, Xueying Wang, He Dou, Xi Yu, Zhiren Zhang, Shanshan Yang, Min Xiao   +8 more
semanticscholar   +1 more source