Results 11 to 20 of about 5,576,002 (348)
Necroptosis and tumor progression.
Trends in Cancer, 2021 Necroptosis, a form of programmed necrotic cell death, is a gatekeeper of host defense against certain pathogen invasions. The deregulation of necroptosis is also a key factor of many inflammatory diseases. Recent studies have revealed an important role of necroptosis in tumorigenesis and metastasis and imply the potential of targeting necroptosis as a
Jiong Yan +3 more
semanticscholar +3 more sources
Stromal cells in the tumor microenvironment: accomplices of tumor progression?
Cell Death and Disease, 2023 The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.
Yan Zhao +9 more
semanticscholar +1 more source
The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis
Journal of Hematology & Oncology, 2022 Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic development and tissue regeneration. However, aberrant reactivation of EMT is associated with malignant properties of tumor cells during cancer progression and metastasis,
Yuhe Huang, Weiqi Hong, Xiawei Wei
semanticscholar +1 more source
Dynamic EMT: a multi‐tool for tumor progression
EMBO Journal, 2021 The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire mesenchymal features, and become motile.
S. Brabletz +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term.
Hannah Wurzer +16 more
doaj +1 more source
The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus
Scientific Reports, 2022 Evidence from previous studies suggests a protective effect of metformin in patients with colorectal cancer (CRC). The aim of this study was to examine the associations between metformin use and overall survival (OS) and disease-free survival (DFS) in ...
Zeinab Tarhini +5 more
doaj +1 more source
Frontiers in Oncology, 2023 BackgroundIn the context of personalized medicine, screening patients to identify targetable molecular alterations is essential for therapeutic decisions such as inclusion in clinical trials, early access to therapies, or compassionate treatment.
Sandra Pinet +26 more
doaj +1 more source
Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]
, 2013 Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
A Ho-Pun-Cheung +45 more
core +6 more sources
Role of ferroptosis on tumor progression and immunotherapy
Cell Death Discovery, 2022 Ferroptosis is triggered by intracellular iron leading to accumulation of lipid peroxidation consequent promotion of cell death. Cancer cell exhibits ability to evade ferroptosis by activation of antioxidant signaling pathways such as SLC7A11/GPX4 axis ...
Deting Gong +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 Congenital defects of the immune system called primary immunodeficiency disorders (PID) describe a group of diseases characterized by a decrease, an absence, or a malfunction of at least one part of the immune system.
Jérôme Mastio +5 more
doaj +1 more source