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The Role of Cancer-Associated Fibroblasts in Tumor Progression
Cancers, 2021 Simple Summary As our knowledge of cancer as a complex organ comprising tumor cells as well as surrounding cells within the microenvironment continues to grow, it is imperative to consider how the microenvironment may be supporting the cancer and ...
Rushikesh S. Joshi +5 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 The Notch signaling pathway plays an essential role in a wide variety of biological processes including cell fate determination of vascular endothelial cells and the regulation of arterial differentiation and angiogenesis.
Abdellah Akil +6 more
semanticscholar +1 more source
Every which way? On predicting tumor evolution using cancer progression models [PDF]
, 2019 Successful prediction of the likely paths of tumor progression is valuable for diagnostic, prognostic, and treatment purposes. Cancer progression models (CPMs) use cross-sectional samples to identify restrictions in the order of accumulation of driver ...
Díaz-Uriarte, Ramón, Vasallo, Claudia
core +2 more sources
Mitochondrial Fission and Fusion in Tumor Progression to Metastasis
Frontiers in Cell and Developmental Biology, 2022 Mitochondria are highly dynamic organelles which can change their shape, via processes termed fission and fusion, in order to adapt to different environmental and developmental contexts.
D. Boulton, M. Caino
semanticscholar +1 more source
Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]
, 2015 Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe +16 more
core +3 more sources
Metabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis
Metabolites, 2021 Cancer cells face various metabolic challenges during tumor progression, including growth in the nutrient-altered and oxygen-deficient microenvironment of the primary site, intravasation into vessels where anchorage-independent growth is required, and ...
K. Ohshima, E. Morii
semanticscholar +1 more source
Tumorigenicity of IL-1α– and IL-1β–Deficient Fibrosarcoma Cells
Neoplasia: An International Journal for Oncology Research, 2008 Analyzing the growth of fibrosarcoma lines derived from IL-1α–, IL-1β–, or IL-1αβ–knockout (−/−) mice in the immunocompetent host revealed that tumor-derived IL-1α and IL-1β exert strong and opposing effects on immune response induction, which prohibited
Irina Nazarenko +9 more
doaj +1 more source
Cancer Medicine, 2023 Objectives The time for posttreatment tumor progression differs between nasopharyngeal carcinoma (NPC) patients. Herein, we established effective nomograms for predicting early tumor progression (ETP) and late tumor progression (LTP) in NPC patients ...
Lu‐Lu Zhang +7 more
doaj +1 more source
Regulatory T cells with multiple suppressive and potentially pro-tumor activities accumulate in human colorectal cancer [PDF]
, 2016 Tregs can contribute to tumor progression by suppressing antitumor immunity. Exceptionally, in human colorectal cancer (CRC), Tregs are thought to exert beneficial roles in controlling pro-tumor chronic inflammation.
BARNABA, Vincenzo +14 more
core +1 more source
Immunohistochemical Expression of Tensin-4/CTEN in Squamous Cell Carcinoma in Dogs
Veterinary Sciences, 2023 C-terminal tensin-like (tensin-4/TNS4/CTEN) is the fourth member of the tensin family, frequently described as displaying oncological functions, including cellular migration, invasion, adhesion, growth, metastasis, epithelial to mesenchymal transition ...
Alexandra Monteiro +5 more
doaj +1 more source