Results 211 to 220 of about 1,355,842 (299)

Correction: Automated tumor stroma ratio assessment in colorectal cancer using hybrid deep learning approach. [PDF]

Sci Rep
Armand TPT, Bhattacharjee S, Nfor KA, Kim HC.   +3 more
europepmc   +1 more source

TP53 mutations orchestrate partial EMT states in oral squamous cell carcinoma: spatially resolved and in vitro preliminary insights into tumour plasticity

The Journal of Pathology, EarlyView.
Abstract TP53 is the most frequently mutated gene in oral squamous cell carcinoma (OSCC); however, its role in promoting epithelial–mesenchymal transition (EMT) and tumour progression remains unclear, particularly within the context of intra‐tumour heterogeneity.
Rana Alaaeldin Ibrahim, Hong Wan, Raju Kumar, Muy‐Teck Teh, Angray Kang, Emma Bailey, Hannah Cottom, Adrian Biddle, Inês Sequeira, Farida Fortune   +9 more
wiley   +1 more source

DeCAF defines clinical fibroblast subtypes and multidimensional tumor-stroma crosstalk shaping prognosis and immunotherapy response. [PDF]

Cell Rep Med
Peng XL, McCabe IC, Kharitonova EV, Xu Y, Zhao RT, Luan C, Kearney JF, Kren NP, Hariharan A, Lee JJ, Su J, Chan PS, Morrison AB, LaBella ME, Herera Loeza SG, Cliff A, Kim HJ, Pylayeva-Gupta Y, Tsai S, Belt BA, Panni RZ, Linehan DC, Gomez SM, Damrauer JS, Iuga AC, Kim WY, Rashid NU, Yeh JJ.   +27 more
europepmc   +1 more source

Molecular, spatial, and AI‐enabled technologies for predicting neoadjuvant therapy response in locally advanced rectal cancer

The Journal of Pathology, EarlyView.
Abstract Pretreatment prediction of neoadjuvant response remains an unresolved challenge in locally advanced rectal cancer, where management is moving towards risk‐adapted and response‐oriented treatment strategies. Prediction remains difficult because response reflects interacting tumour‐intrinsic, immune, stromal, and spatial processes that are ...
Gina F Boot, Cibele Masotti, Claudia Corrò, Cédric Schraepen, Hannah L Williams, Thomas A Wright, Fiza Ishaqwala, Colin W Steele, Gertjan Rasschaert, Maxime W Lafarge, Enric Domingo, Inti Zlobec, Rodrigo Oliva Perez, Campbell SD Roxburgh, Timothy S Maughan, Sabine Tejpar, Thibaud Koessler, Viktor H Koelzer   +17 more
wiley   +1 more source

Concordance and Prognostic Impact of Tumor-Stroma Ratio and Tumor-Infiltrating Lymphocytes in Preoperative Biopsies and Matched Surgical Specimens in Oral Squamous Cell Carcinoma. [PDF]

Diagnostics (Basel)
Mozola M, Herman M, Brachtlova K, Michalek J, Zapletalova J, Bednarik Z, Hendrych M, Pink R, Tvrdy P, Hermanova M.   +9 more
europepmc   +1 more source

C–X–C Motif Chemokine Receptor 4 (CXCR4)‐Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited‐Stage Small Cell Lung Cancer

Precision Radiation Oncology, EarlyView.
A newly proposed proton spatially fractionated radiotherapy guided by biological imaging Abstract Background and Purpose To evaluate the feasibility and dosimetric safety of integrating C–X–C motif chemokine receptor 4 (CXCR4)‐targeted tracer 18F‐AlF‐NOTA‐QHY‐04 positron emission tomography imaging with biologically guided proton spatially fractionated
Keru Pu, Tengxiang Li, Shengnan Xu, Xue Sha, Qingtao Qiu, Jinming Yu, Yong Yin, Jie Liu   +7 more
wiley   +1 more source

A Deep Learning-Generated Mixed Tumor-Stroma Ratio for Prognostic Stratification and Multi-omics Profiling in Bladder Cancer. [PDF]

Research (Wash D C)
He Y, Xie J, Zhong S, Zhan C, Dai F, Lai H, Wang M, He Y, Patel H, Chen ZS, Zhong B, Qiu X, Guo Y, Zheng Z.   +13 more
europepmc   +1 more source

Human Prostate Cell Lines: Derivation, Molecular Characteristics and Appropriate Use

The Prostate, EarlyView.
ABSTRACT Background Research on prostate cancer and benign prostatic hyperplasia depends on a small number of immortalized human cell lines established between 1977 and 2001, most of them from advanced metastatic disease. The cell lines differ from one another in androgen receptor status, prostate‐specific antigen secretion, p53 status, karyotype and ...
Hamza Abohamra, Keenau Mark Pearce
wiley   +1 more source

PET and SPECT Imaging of Macrophages in the Tumor Stroma: An Update. [PDF]

J Clin Med
Li S, Maes A, Vermassen T, Maes J, Sathekge C, Rottey S, Van de Wiele C.   +6 more
europepmc   +1 more source

Comparison of Gene Enrichment Between Prostate Tissue and Urine for Non‐Invasive Biomarker Development

The Prostate, EarlyView.
ABSTRACT Background For prostate cancer (PCa), early diagnosis and biomarker‐based patient stratification can improve clinical decision‐making and post‐treatment prognosis. PCa biomarkers are best validated in tissue following comprehensive histopathologic review; however, urinary biomarkers can be obtained non‐invasively and are therefore safer and ...
Yuandong Xing, Minqi Xu, Dan Dion, Vanessa F. Bratti, Ania A. Namin, D. Robert Siemens, Palak G. Patel, Robert J. Gooding, Jane Bayani, Hamid Ghaedi, Anna Y. Lee, David M. Berman   +11 more
wiley   +1 more source