Results 21 to 30 of about 481,131 (293)

Retinoblastoma Protein Paralogs and Tumor Suppression

open access: yesFrontiers in Genetics, 2022
The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
doaj   +1 more source

Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review

open access: yesIranian Journal of Public Health, 2021
Background: The tumor suppressor genes play a critical role in cellular and molecular mechanisms such as cell cycle processes, cell differentiation and apoptosis.
Sara Sheikkholeslami   +6 more
doaj   +1 more source

Clinicopathological and targeted exome gene features of a patient with metastatic acinic cell carcinoma of the parotid gland harboring an ARID2 nonsense mutation and CDKN2A/B deletion [PDF]

open access: yes, 2015
We describe the presentation, treatment, clinical outcome, and targeted genome analysis of a metastatic salivary acinic cell carcinoma (AciCC). A 71-year-old male presented with a 3 cm right tail of a parotid lesion, first detected as a nodule by the ...
Momand, Jamil   +4 more
core   +12 more sources

Transcriptomic profiling disclosed the role of DNA methylation and histone modifications in tumor-infiltrating myeloid-derived suppressor cell subsets in colorectal cancer [PDF]

open access: yes, 2020
Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor metastasis.
Abu Nada, M   +9 more
core   +3 more sources

G‐quadruplex‐enhanced circular single‐stranded DNA (G4‐CSSD) adsorption of miRNA to inhibit colon cancer progression

open access: yesCancer Medicine, 2023
Background Chromosomal heterogeneity leads to the abnormal expression and mutation of tumor‐specific genes. Drugs targeting oncogenes have been extensively developed.
Haidong Wu   +9 more
doaj   +1 more source

Significance of promoter methylation of multiple tumor suppressor genes in hepatocellular carcinoma

open access: yesEgyptian Journal of Medical Human Genetics, 2022
Background Methylation of the promoter at CpG islands is a mechanism of silencing tumor suppressor genes and therefore enhances cancer progression.
Alaa Tahoon   +4 more
doaj   +1 more source

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context [PDF]

open access: yes, 2018
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling ...
Abdel-Rahman, Mohamed H.   +736 more
core   +3 more sources

Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer

open access: yesFrontiers in Genetics, 2020
In this article, we make a theoretical and in silico study for uncovering and evaluating biomarkers in colon and rectal cancer (CRC) by the dynamic network biomarker (DNB) theory.
Yanqiu Tong   +4 more
doaj   +1 more source

Prediction Of Cancer Possibility By Pattern Recognition And Statistical Study Of Expression Of Gene Level Of Cancer Cells [PDF]

open access: yes, 2011
The activity of the p53 tumor-suppressor protein has a key role in controlling both cancer and aging: under activity encourages the growth of cancer, and over activity can accelerate the aging process.
Devang Odedra, Medhavi Mallick
core   +2 more sources

Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]

open access: yes, 2014
BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo   +8 more
core   +3 more sources

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