Results 51 to 60 of about 2,711,825 (248)

VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]

, 2006
Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core   +1 more source

Targeting the tumor vasculature with engineered cystine-knot miniproteins

Nature Communications, 2020
Cystine-knot miniprotein are small, highly stable, disulfide-rich peptides with increasing potential as drugs and tumor imaging agents. Here the authors develop cystine-knot miniproteins targeting the vascular tumor marker EDB, and use them as probes for
Bonny Gaby Lui, Nadja Salomon, Joycelyn Wüstehube-Lausch, Matin Daneschdar, Hans-Ulrich Schmoldt, Özlem Türeci, Ugur Sahin   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Targeting human synovium using homing peptides identified by in vivo phage display [PDF]

, 2009
PhDRheumatoid arthritis (RA) is a chronic inflammatory condition affecting diarthrodial synovial joints. Non-random patterns of inflammatory cell recruitment suggest the presence of synovial-specific vascular determinants which enable recruitment of ...
Garrood, Toby
core   +4 more sources

An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone

Experimental and Molecular Medicine, 2023
Brain tumours: antibody blocks blood vessel abnormality An antibody targeting key signalling pathways could prevent brain tumor vessels from being abnormal, thereby improving drug delivery into tumor tissues.
Eunhyeong Lee, Eun-Ah Lee, Eunji Kong, Haemin Chon, Melissa Llaiqui-Condori, Cheon Ho Park, Beom Yong Park, Nu Ri Kang, Jin-San Yoo, Hyun-Soo Lee, Hyung-Seok Kim, Sung-Hong Park, Seung-Won Choi, Dietmar Vestweber, Jeong Ho Lee, Pilhan Kim, Weon Sup Lee, Injune Kim   +17 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging [PDF]

, 2003
ZD6126 is a vascular targeting agent that disrupts the tubulin cytoskeleton of proliferating neo-endothelial cells. This leads to the selective destruction and congestion of tumour blood vessels in experimental tumours, resulting in extensive ...
J R Griffiths, McIntyre, D. J O, Blakey, D. C., Checkley, D, Blakey, DC, Griffiths, J. R., A J Ryan, Howe, F. A., D Checkley, McIntyre, DJ, Waterton, JC, D J O McIntyre, Robinson, S. P., S P Robinson, Robinson, SP, S E Ashton, F A Howe, D C Blakey, Griffiths, JR, Waterton, J. C., Ryan, AJ, Ryan, A. J., Tessier, JJ, Howe, FA, Checkley, D., Tessier, J. J., Ashton, SE, Ashton, S. E., J J Tessier, J C Waterton   +29 more
core   +1 more source

Intravital imaging reveals spatiotemporal dynamics of oncolytic Salmonella YB1-induced intratumoral vascular thrombosis and tumor targeting

Frontiers in Immunology
IntroductionIn recent years, oncolytic bacterial therapy has emerged as a promising strategy in cancer research due to its unique advantages in tumor targeting and immune activation. Among various bacterial candidates, Salmonella demonstrates exceptional
Bin Yu, Lei Shi, Lei Shi, Lei Shi, Weiwang Duan, Dongmei Cui, Edwin R. Manuel, Wei Huang   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source