Results 61 to 70 of about 2,711,825 (248)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice

OncoImmunology, 2017
When compared with vascular cells in normal tissues, pericytes and vascular endothelial cells (VEC) in tumor blood vessels exhibit altered morphology and epigenetic programming that leads to the expression of unique antigens that allow for differential ...
Kellsye Paula L. Fabian, Nina Chi-Sabins, Jennifer L. Taylor, Ronald Fecek, Aliyah Weinstein, Walter J. Storkus   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Exploring functional mechanisms underlying tumor initiation, EMT and cell migration [PDF]

, 2012
Cancer is one of the leading causes of death. A primary tumor forms when cells start to proliferate in an uncontrolled way and stop reacting to restraining signals.
Gruber, Dorothea Cornelia
core   +1 more source

Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

OncoImmunology
Gastrointestinal stromal tumors (GISTs) harbor diverse immune cell populations but so far immunotherapy in patients has been disappointing. Here, we established cord blood humanized mouse models of localized and disseminated GIST to explore the ...
Bo He, Larissa Dymond, Kira H. Wood, Edward R. Bastow, Jiulia Satiaputra, Ji Li, Anna Johansson-Percival, Juliana Hamzah, M. Priyanthi Kumarasinghe, Mohammed Ballal, Jonathan Foo, Mikael Johansson, Hooi C. Ee, Scott W. White, Louise Winteringham, Ruth Ganss   +15 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Targeting Strategies for the Combination Treatment of Cancer Using Drug Delivery Systems

Pharmaceutics, 2017
Cancer cells have characteristics of acquired and intrinsic resistances to chemotherapy treatment—due to the hostile tumor microenvironment—that create a significant challenge for effective therapeutic regimens.
Janel Kydd, Rahul Jadia, Praveena Velpurisiva, Aniket Gad, Shailee Paliwal, Prakash Rai   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Molecular targeting of prostate cancer cells by a triple drug combination down-regulates integrin driven adhesion processes, delays cell cycle progression and interferes with the cdk-cyclin axis [PDF]

, 2011
Background: Single drug use has not achieved satisfactory results in the treatment of prostate cancer, despite application of increasingly widespread targeted therapeutics.
Eva Juengel, Hudak, Lukasz, Waaga, Ana Maria da Silva Rosa, Roman A Blaheta, Lukasz Hudak, Blaheta, Roman A., Igor Tsaur, Makarević, Jasmina, Haferkamp, Axel, Jens-Michael Seibel, Wedel, Steffen, Haferkamp Axel, Waaga-Gasser Ana, Seibel Jens-Michael, Juengel Eva, Blaheta Roman A, Makarević Jasmina, Waaga-Gasser, Ana, Jasmina Makarević, Axel Haferkamp, Wedel Steffen, Jüngel, Eva, Seibel, Jens-Michael, Ana Waaga-Gasser, Tsaur Igor, Juengel, Eva, Wedel, Steffen Alexander, Tsaur, Igor, Hudak Lukasz, Steffen Wedel   +29 more
core   +2 more sources

Tumor-Targeted nitric Oxide-Loaded nanoliposomes for modulating the tumor microenvironment and enhancing the efficacy of dacarbazine in melanoma

Materials & Design
Background: Malignant melanoma is a highly malignant tumor that results from the malignant transformation of melanocytes. It is mainly accompanied by changes in the immune microenvironment and severe intra-tumor vascular abnormalities, which ...
Yueling Yang, Jiaxuan Gan, Ziyao Xie, Xinyu Su, Yirong Wu, Lanqun Qin, Jiayu Wang, Mengke Zhao, Zhengyun Zou   +8 more
doaj   +1 more source