Results 1 to 10 of about 78,212 (168)

Dual Face of Vγ9Vδ2-T Cells in Tumor Immunology: Anti- versus Pro-Tumoral Activities

Frontiers in Immunology, 2017
Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity.
Zheng Xiang, Wenwei Tu
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Tumor Hypoxia and Circulating Tumor Cells [PDF]

International Journal of Molecular Sciences, 2020
Circulating tumor cells (CTCs) are a rare tumor cell subpopulation induced and selected by the tumor microenvironment’s extreme conditions. Under hypoxia and starvation, these aggressive and invasive cells are able to invade the lymphatic and circulatory systems.
Tinganelli W., Durante M.
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Carbazole Derivatives as STAT Inhibitors: An Overview

Applied Sciences, 2021
The carbazole class is made up of heterocyclically structured compounds first isolated from coal tar. Their structural motif is preponderant in different synthetic materials and naturally occurring alkaloids extracted from the taxonomically related ...
Anna Caruso, Alexia Barbarossa, Alessia Carocci, Giovanni Salzano, Maria Stefania Sinicropi, Carmela Saturnino   +5 more
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The Role of V-Domain Ig Suppressor of T Cell Activation (VISTA) in Cancer Therapy: Lessons Learned and the Road Ahead

Frontiers in Immunology, 2021
Immune checkpoints (ICs) have pivotal roles in regulating immune responses. The inhibitory ICs in the tumor microenvironment (TME) have been implicated in the immune evasion of tumoral cells.
Negar Hosseinkhani, Negar Hosseinkhani, Negar Hosseinkhani, Afshin Derakhshani, Afshin Derakhshani, Mahdi Abdoli Shadbad, Mahdi Abdoli Shadbad, Antonella Argentiero, Vito Racanelli, Tohid Kazemi, Ahad Mokhtarzadeh, Oronzo Brunetti, Nicola Silvestris, Nicola Silvestris, Behzad Baradaran, Behzad Baradaran, Behzad Baradaran   +16 more
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Adaptive Subsets Limit the Anti-Tumoral NK-Cell Activity in Hepatocellular Carcinoma

Cells, 2021
Hepatocellular carcinoma (HCC) is a global health burden with increasing incidence, poor prognosis and limited therapeutic options. Natural killer (NK) cells exhibit potent anti-tumoral activity and therefore represent potential targets for ...
Charlotte Rennert, Catrin Tauber, Pia Fehrenbach, Kathrin Heim, Dominik Bettinger, Özlem Sogukpinar, Anita Schuch, Britta Franziska Zecher, Bertram Bengsch, Sven A. Lang, Peter Bronsert, Niklas K. Björkström, Stefan Fichtner-Feigl, Michael Schultheiss, Robert Thimme, Maike Hofmann   +15 more
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Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1

OncoImmunology, 2022
Interleukin-1α (IL-1α) plays an important role in inflammation and hematopoiesis. Many tumors have increased IL-1α expression. However, the immune regulatory role of secreted IL-1α in tumor development and whether it can be targeted for cancer therapy ...
Dandan Lin, Yu Mei, Lei Lei, Zuhairah Binte Hanafi, Ziqi Jin, Yonghao Liu, Yuan Song, Yinsheng Zhang, Bo Hu, Chunliang Liu, Jinhua Lu, Haiyan Liu   +11 more
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Prognostic significance of natural killer cell-associated markers in gastric cancer: quantitative analysis using multiplex immunohistochemistry

Journal of Translational Medicine, 2021
Background Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication of NK cell-associated surface ...
Hee Young Na, Yujun Park, Soo Kyung Nam, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Kyu Sang Lee, Hye Seung Lee   +9 more
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Circulating tumor cells in genitourinary tumors [PDF]

Therapeutic Advances in Urology, 2017
Management of advanced urogenital malignancies has profoundly changed in recent years due to the development of novel targeted drugs that have significantly improved patient’s clinical outcomes. This process has been made possible mainly thanks to better knowledge of tumor genetic alterations and molecular altered pathways.
Massari, Francesco, Di Nunno, Vincenzo, COMITO, FRANCESCA, CUBELLI, MARTA, Ciccarese, Chiara, Iacovelli, Roberto, Fiorentino, Michelangelo, Montironi, Rodolfo, Ardizzoni, Andrea   +8 more
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From Oncogenic Signaling Pathways to Single-Cell Sequencing of Immune Cells: Changing the Landscape of Cancer Immunotherapy

Molecules, 2021
Over the past decade, there have been remarkable advances in understanding the signaling pathways involved in cancer development. It is well-established that cancer is caused by the dysregulation of cellular pathways involved in proliferation, cell cycle,
Afshin Derakhshani, Zeinab Rostami, Hossein Safarpour, Mahdi Abdoli Shadbad, Niloufar Sadat Nourbakhsh, Antonella Argentiero, Sina Taefehshokr, Neda Jalili Tabrizi, Omid Kooshkaki, Reza Vaezi Astamal, Pankaj Kumar Singh, Nima Taefehshokr, Nazila Alizadeh, Nicola Silvestris, Behzad Baradaran   +14 more
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Spatial and Temporal Heterogeneity in Clonal Evolution of Nonsmall-cell Lung Cancer: Implications for Therapy

Forum of Clinical Oncology, 2023
Tumoral heterogeneity has been associated with treatment resistance and failure in patients with cancer. Tumoral heterogeneity can be either intertumoral (static variation of cancer cells) or intratumoral (spatial and temporal variation of cancer cells).
Koulouris A., Tsagkaris C., Mountzios G.
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