Results 21 to 30 of about 97,107 (209)

Tumor Endothelial Cells [PDF]

Cold Spring Harbor Perspectives in Medicine, 2011
The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In tumors, factors such as hypoxia and chronic growth factor stimulation result in endothelial dysfunction.
openaire   +2 more sources

Tumor Cells and the Extracellular Matrix Dictate the Pro-Tumoral Profile of Macrophages in CRC [PDF]

, 2021
Tumor-associated macrophages (TAMs) are major components of the tumor microenvironment. In colorectal cancer (CRC), a strong infiltration of TAMs is accompanied by a decrease in effector T cells and an increase in the metastatic potential of CRC.
Marco Agostini, Coletta, Sara, Annica Barizza, Della Bella, Chiara, Barizza, Annica, D'Angelo, Edoardo, Fassan, Matteo, de Bernard, Marina, Pucciarelli, Salvatore, Mario Milco D’Elios, Chiara Della Bella, Andrea Biccari, Salvatore Pucciarelli, Edoardo D’Angelo, Sensi, Francesca, Matteo Fassan, Gaia Codolo, Biccari, Andrea, D'Elios, Mario Milco, Sara Coletta, Silvia Lonardi, Arianna Valzelli, William Vermi, Codolo, Gaia, Valzelli, Arianna, Lonardi, Silvia, Vermi, William, Agostini, Marco, Marina de Bernard, Francesca Sensi   +29 more
core   +1 more source

Differential modulation of cell morphology, migration, and Neuropilin-1 expression in cancer and non-cancer cell lines by substrate stiffness

Frontiers in Cell and Developmental Biology
Physical changes in the tumor microenvironment, such as increased stiffness, regulate cancer hallmarks and play an essential role in gene expression, cell morphology, migration, and malignancy.
Ana Monserrat Vela-Alcántara, Ana Monserrat Vela-Alcántara, Juan Santiago-García, Madeleine Barragán-Palacios, Madeleine Barragán-Palacios, Aylin León-Chacón, Marilú Domínguez-Pantoja, Irene Barceinas-Dávila, Irene Barceinas-Dávila, Enrique Juárez-Aguilar, Elisa Tamariz   +10 more
doaj   +1 more source

Elimination of classically-activated macrophages in tumor-conditioned medium by alternatively-activated macrophages

Biology Open, 2017
Cellular interactions are critical during development, tissue fitness and epithelial tumor development. The expression levels of specific genes confer to tumoral cells a survival advantage versus the normal neighboring cells.
Fidel-Nicolás Lolo, Cristina Rius, Sergio Casas-Tintó   +2 more
doaj   +1 more source

Transcriptome profiling of human col\onic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus.

PLoS ONE, 2023
Streptococcus gallolyticus sp. gallolyticus (SGG) is a gut pathobiont involved in the development of colorectal cancer (CRC). To decipher SGG contribution in tumor initiation and/or acceleration respectively, a global transcriptome was performed in human
Ewa Pasquereau-Kotula, Laurence du Merle, Odile Sismeiro, Natalia Pietrosemoli, Hugo Varet, Rachel Legendre, Patrick Trieu-Cuot, Shaynoor Dramsi   +7 more
doaj   +1 more source

Multi-agent system simulating tumoral cells migration

, 2005
International audienceThe migration of tumoral Cells through the biological barrier constitutes the major dynamic event of tumoral invasion. This article presents the CellMigration system that we have realized under multi-agent platform (oriented object)
Guessoum, Zahia, Dib, Lynda
core   +1 more source

Comparative proteomics of exosomes secreted by tumoral jurkat t cells and normal human t cell blasts unravels a potential tumorigenic role for valosin-containing protein [PDF]

, 2016
We have previously characterized that FasL and Apo2L/TRAIL are stored in their bioactive form inside human T cell blasts in intraluminal vesicles present in multivesicular bodies.
Gallego-Lleyda, Ana, María Iturralde, Gallego-Lleyda, A., Ana Gallego-Lleyda, Iturralde, María, Martínez-Lostao, Luis, Anel, A., Thierse, H.J., Alberto Anel, Bosque, Alberto, Naval, J., Sanclemente, Manuel, Hermann-Josef Thierse, Alberto Bosque, Thierse, Hermann-Josef, Javier Naval, Alava, M.A., Dietz, Lisa, Dietz, L., Iturralde, M., Manuel Sanclemente, Alava, María Angeles, María Angeles Alava, Bosque, A., Naval, Javier, Luis Martínez-Lostao, Anel, Alberto, Alava, Maria A., Lisa Dietz, Martínez-Lostao, L, Sanclemente, M.   +30 more
core   +1 more source

Mucinous urothelial carcinoma of the renal pelvis

Rare Tumors, 2014
Urothelial carcinoma with abundant myxoid stroma is a newly-described and extremely rare entity. Since only very few cases have been reported, there is no consensus on its nomenclature.
Kemal Behzatoğlu, Ceren Boyacı, Oğuzhan Okçu, Ezgi Hacıhasanoğlu, Yasemin Çakır, Seher Darakçı   +5 more
doaj   +1 more source

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

OncoImmunology, 2018
Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra ...
Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom, Marco J. Bruno   +16 more
doaj   +1 more source

Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis

Journal of Experimental & Clinical Cancer Research, 2021
Breast cancer is a heterogeneous disease with a complex microenvironment consisting of tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells shape the tumor microenvironment (TME) and influence the progression of breast
Xueqi Yan, Yinghong Xie, Fan Yang, Yijia Hua, Tianyu Zeng, Chunxiao Sun, Mengzhu Yang, Xiang Huang, Hao Wu, Ziyi Fu, Wei Li, Shiping Jiao, Yongmei Yin   +12 more
doaj   +1 more source