Results 11 to 20 of about 97,107 (209)

High Levels of Progesterone Receptor B in MCF-7 Cells Enable Radical Anti-Tumoral and Anti-Estrogenic Effect of Progestin

Biomedicines, 2022
The widely reported conflicting effects of progestin on breast cancer suggest that the progesterone receptor (PR) has dual functions depending on the cellular context.
Natasa Bajalovic, Yu Zuan Or, Amanda R. E. Woo, Shi Hao Lee, Valerie C. L. Lin   +4 more
doaj   +2 more sources

ΔM4: Membrane-Active Peptide with Antitumoral Potential against Human Skin Cancer Cells

Membranes, 2023
Peptides have become attractive potential agents due to their affinity to cancer cells. In this work, the biological activity of the peptide ΔM4 against melanoma cancer cell line A375, epidermoid carcinoma cell line A431, and non-tumoral HaCaT cells was ...
Estefanía Fandiño-Devia, Gloria A. Santa-González, Maria C. Klaiss-Luna, Ibeth Guevara-Lora, Verónica Tamayo, Marcela Manrique-Moreno   +5 more
doaj   +1 more source

Circulating Tumor Cells in Patients with Testicular Germ Cell Tumors [PDF]

Clinical Cancer Research, 2014
Abstract Purpose: Germ cell tumors (GCTs) represent the most frequent malignancies among young men, but little is known about circulating tumor cells (CTCs) in these tumors. Considering their heterogeneity, CTCs were investigated using two independent assays targeting germ cell tumor and epithelial cell–specific markers, and results ...
P. Nasta y, C. Ruf, P. Becker, N. Bednarz-Knoll, M. Stoupiec, R. Kavsur, H. Isbarn, C. Matthies, W. Wagner, D. Hoppner, M. Fisch, C. Bokemeyer, S. Ahyai, F. Honecker, S. Riethdorf, K. Pantel   +15 more
openaire   +2 more sources

Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro [PDF]

, 2001
Angiogenesis, the formation of a new blood supply, is an essential step in tumorigenesis. Although vascular endothelial growth factor (VEGF) is known to be a very potent angiogenic factor in most solid tumors, little is known about its production and ...
Losa, Marco, Lohrer, P., Gloddek, J., Renner, U., Lohrer, Penny, Uhl, E., Stalla, G., Pagotto, U., Hopfner, Ursula, Renner, Ulrich, Losa, Marc, Losa, M., Pagotto, Uberto, Gloddek, Jutta, Uhl, Eberhard, Stalla, Günter K., Hopfner, U.   +16 more
core   +1 more source

Tumor cell dormancy [PDF]

Molecular Oncology, 2017
Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years, or even decades.
Gomis i Cabré, Roger, Gawrzak, Sylwia
openaire   +3 more sources

FOXP3 in Melanoma with Regression: Between Tumoral Expression and Regulatory T Cell Upregulation

Journal of Immunology Research, 2020
Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment.
Mirela Cioplea, Luciana Nichita, Daniela Georgescu, Liana Sticlaru, Alexandra Cioroianu, Roxana Nedelcu, Gabriela Turcu, Alin Rauta, Cristian Mogodici, Sabina Zurac, Cristiana Popp   +10 more
doaj   +1 more source

Tumor cell intravasation [PDF]

American Journal of Physiology-Cell Physiology, 2016
The process of entering the bloodstream, intravasation, is a necessary step in the development of distant metastases. The focus of this review is on the pathways and molecules that have been identified as being important based on current in vitro and in vivo assays for intravasation.
Serena P H, Chiang, Ramon M, Cabrera, Jeffrey E, Segall   +2 more
openaire   +2 more sources

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus [PDF]

, 2010
Background CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level
Young Lawrence S, Elmetwali, Taha, Mcneish, I., Searle Peter F, Young, Lawrence, Searle, PF, Palmer Daniel H, McNeish, I, Young, Lawrence S., Palmer, D.H., McNeish, Iain, Peter F Searle, Lawrence S Young, Elmetwali, T., Searle, P.F., Elmetwali Taha, Iain McNeish, Young, LS, McNeish Iain, Palmer, Daniel H., Palmer, DH, Searle, Peter F., Daniel H Palmer, Young, L.S., Taha Elmetwali, Palmer, Daniel, Searle, Peter, Elmetwali, T   +27 more
core   +1 more source

NTSR1 glycosylation and MMP dependent cleavage generate three distinct forms of the protein

Scientific Reports, 2023
NTSR1 abnormal expression by cancer cells makes it a strategic target for antitumoral therapies, such as compounds that use NTSR1 binding probes to deliver cytotoxic agents to tumor cells.
Fotine Libanje, Raphael Delille, Pamela A Young, Sylvie Rolland, Florence Meyer-Losic, Elodie Lewkowicz, Stephan Klinz   +6 more
doaj   +1 more source

Neutrophils in Gliomas

Frontiers in Immunology, 2017
Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation ...
Matteo Massara, Matteo Massara, Pasquale Persico, Ornella Bonavita, Ornella Bonavita, Valeria Mollica Poeta, Valeria Mollica Poeta, Massimo Locati, Massimo Locati, Matteo Simonelli, Matteo Simonelli, Raffaella Bonecchi, Raffaella Bonecchi   +12 more
doaj   +1 more source