Results 71 to 80 of about 855,290 (307)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Related factors of turnover intention among general practitioners: a cross-sectional study in 6 provinces of China

BMC Primary Care
Background Turnover among general practitioners (GPs) is an issue of growing concern. Therefore, identification of the variables which associated with GPs’ decision in staying in or leaving their employer institutions is necessary.
Yanchun Sun, Wei Wang, Fei Yan, Xueqin Xie, Min Cai, Fang Xu, Yi Qian, Yuanyuan Xiao, Chuanzhi Xu, Wenlan Zhao   +9 more
doaj   +1 more source

Team climate, intention to leave and turnover among hospital employees: Prospective cohort study [PDF]

, 2007
Background In hospitals, the costs of employee turnover are substantial and intentions to leave among staff may manifest as lowered performance. We examined whether team climate, as indicated by clear and shared goals, participation, task orientation and
Lansisalmi, H, Länsisalmi Hannakaisa, Marko Elovainio, Vanhala Anna, Virtanen, M, Mika Kivimäki, Pentti, J, Vahtera, J, Elovainio Marko, Elovainio, M, Kivimäki Mika, Pentti Jaana, Jaana Pentti, Anna Vanhala, Kivimaki, M, Vahtera Jussi, Vanhala, A, Jussi Vahtera, Marianna Virtanen, Hannakaisa Länsisalmi, Virtanen Marianna   +20 more
core   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Psychological Contract Breach and Employee Turnover Intention: A Moderated Meditation Model

, 2022
Based on the theories of social exchange and ego control, this study aimed to explore how ego depletion and leader-member exchange affect the relationship between psychological contract breach and employee turnover intention.
Li, Feng, Liu, Xin
core   +1 more source

The Formation Mechanism of Employees’ Turnover Intention in AEC Industry

Buildings
Talent attrition significantly undermines the stable functioning and long-term development of firms in the Architecture, Engineering, and Construction (AEC) industry. Turnover intention is an effective predictor of turnover behavior.
Guanghua Li, Guixian Zhang, Xinyue Zhang, Igor Martek, Danrong Chen   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Turnover behavior and intention among dentists and medical doctors: a cross-sectional study in China

BMC Oral Health
Background Retention of doctors is a global challenge and doctors working in different departments may face different problems. The study aimed to explore the turnover behavior and intention and correlated factors among Chinese dentists and medical ...
Keying Shi, Yong Wang, Zhe Sun, Jing Zhao, Fangyue Xiang, Zhi Chen, Wenjing Sun, Yuanna Zheng   +7 more
doaj   +1 more source

PENGARUH WORK-LIFE BALANCE DAN JOB SATISFACTION TERHADAP TURNOVER INTENTION

Equilibrium: Jurnal Ilmiah Ekonomi, Manajemen dan Akuntansi
ABSTRAK Tingginya angka turnover intention menjadi tantangan serius bagi perusahaan dalam mempertahankan sumber daya manusia yang kompeten. Fenomena ini terlihat jelas di CV.
Muhammad Faqih, Tiara Aulia Asy Syadza, Kartono Kartono   +2 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source