Results 81 to 90 of about 33,292 (313)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Effect of job satisfaction on turnover intention: an empirical investigation on Nigerian banking industry [PDF]

, 2016
Extant literature revealed that job satisfaction has negative effect on employee turnover intention. Despite loss of job satisfaction and high turnover intention among many bank employees in Nigeria very little attention was devoted to examining the ...
Abdullah, Haim Hilman, Kaliappen, Narentheren, Ibrahim, Muhammad Garba   +2 more
core  

Related factors of turnover intention among general practitioners: a cross-sectional study in 6 provinces of China

BMC Primary Care
Background Turnover among general practitioners (GPs) is an issue of growing concern. Therefore, identification of the variables which associated with GPs’ decision in staying in or leaving their employer institutions is necessary.
Yanchun Sun, Wei Wang, Fei Yan, Xueqin Xie, Min Cai, Fang Xu, Yi Qian, Yuanyuan Xiao, Chuanzhi Xu, Wenlan Zhao   +9 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Measuring Push, Pull And Personal Factors Affecting Turnover Intention: A Case Of University Teachers In Pakistan [PDF]

It has been observed that professional and qualified teacher’s retention become a challenge for Higher Education Institutions (HEIs) in Pakistan as the turnover rate has been significantly increased in recent years. The main objective of this paper is to
Iqtidar ALI SHAH, Khalid ZAMAN, Zainab FAKHR, M. Shakil AHMAD   +3 more
core   +1 more source

Explaining turnover intention

Introduction Leaders are important in organizational success because they influence workers’ attitudes and behaviors [1,2]. The Leadership Efficacy Model (LEM) is a recent theoretical proposal focusing on factors that increase leadership efficacy[3]. According to the LEM, three leadership factors can explain the efficacy of leadership.
Sousa, B., Gomes, A. R., Morais, C., Dias-Oliveira, E., Araújo, P., Simães, C.   +5 more
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Turnover behavior and intention among dentists and medical doctors: a cross-sectional study in China

BMC Oral Health
Background Retention of doctors is a global challenge and doctors working in different departments may face different problems. The study aimed to explore the turnover behavior and intention and correlated factors among Chinese dentists and medical ...
Keying Shi, Yong Wang, Zhe Sun, Jing Zhao, Fangyue Xiang, Zhi Chen, Wenjing Sun, Yuanna Zheng   +7 more
doaj   +1 more source

The Formation Mechanism of Employees’ Turnover Intention in AEC Industry

Buildings
Talent attrition significantly undermines the stable functioning and long-term development of firms in the Architecture, Engineering, and Construction (AEC) industry. Turnover intention is an effective predictor of turnover behavior.
Guanghua Li, Guixian Zhang, Xinyue Zhang, Igor Martek, Danrong Chen   +4 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source