Results 41 to 50 of about 2,631 (192)
Real-time assessment of critical quality attributes of a continuous granulation process [PDF]
, 2013 There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off ...
Córdoba Díaz, Damián +6 more
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Pharmaceutics, 2021 Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing.
Ana Alejandra Barrera Jiménez +4 more
doaj +1 more source
Quantitative Assessment of Mass Flow Boundaries in Continuous Twin-screw Granulation
CHIMIA, 2016 In pharmaceutical manufacturing, there is an increasing interest in continuous manufacturing. As an example for fast continuous processes in general of considerable complexity, this study was focussed on improving the understanding of twin-screw
Adrian Schmidt +4 more
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Pharmaceutics, 2022 Twin screw granulation (TSG) is a continuous wet granulation technique that is used widely across different solid manufacturing industries. The TSG has been recognized to have numerous advantages due to its modular design and continuous manufacturing ...
Lalith Kotamarthy +2 more
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Conceptualisation of an Efficient Particle-Based Simulation of a Twin-Screw Granulator
Pharmaceutics, 2021 Discrete Element Method (DEM) simulations have the potential to provide particle-scale understanding of twin-screw granulators. This is difficult to obtain experimentally because of the closed, tightly confined geometry.
John P. Morrissey +2 more
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Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded Nicotinamide Pellets Using a Quality by Design Approach [PDF]
, 2019 Open access articleThe aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation.
Keppler, Julia K +4 more
core +2 more sources
Continuous twin screw rheo-extrusion of an AZ91D magnesium alloy [PDF]
, 2012 © The Minerals, Metals & Materials Society and ASM International 2012The twin screw rheo-extrusion (TSRE) is designed to take advantage of the nondendritc microstructure and thixotropic characterization of semisolid-metal slurries and produce simple ...
A. Das +34 more
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Continuous direct compression as manufacturing platform for sustained release tablets [PDF]
, 2017 This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
Cunningham, C. +7 more
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A quality by design (QbD) twin—screw extrusion wet granulation approach for processing water insoluble drugs [PDF]
, 2017 In this study, a Quality by Design (QbD) approach was used to identify the effect of formulation parameters in a twin screw wet extrusion granulation process for the manufacturing of ibuprofen (IBU) granules with increased dissolution rates. A fractional
Dey, Tumpa +5 more
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Development of nutraceutical product [PDF]
, 2015 The aim of this study was to discuss the development of nutraceutical product which includes the current market trends, challenges, and exploitation of natural resources through various processing.
Chin, Nyuk Ling +2 more
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