Results 31 to 40 of about 2,631 (192)
Pharmaceutics, 2021 The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere +7 more
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Pharmaceutics, 2021 Twin-screw wet granulation is a crucial unit operation in shifting from pharmaceutical batch to continuous processes, but granulation kinetics as well as residence times are yet poorly understood.
Timo Plath +3 more
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Asymmetric distribution in twin screw granulation [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2016 Positron Emission Particle Tracking (PEPT) was successfully employed to validate measured transverse asymmetry in material distribution in the conveying zones of a Twin Screw Granulator (TSG). Flow asymmetry was established to be a property of the granulator geometry and dependent on fill level. The liquid distribution of granules as a function of fill
Tim, Chan Seem +5 more
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Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation
Pharmaceutics, 2021 Experimental characterization of solid-liquid mixing for a high shear wet granulation process in a twin-screw granulator (TSG) is very challenging. This is due to the opacity of the multiphase system and high-speed processing.
Ashish Kumar +4 more
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Ceramics, 2023 This paper investigates new approaches for the blending and plastification of ceramic powder with a binder to form fused deposition of ceramic (FDC) feedstock.
Thomas Heim, Frank Kern
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British Journal of Pharmacy, 2022 The pharmaceutical industry has a growing interest in continuous manufacturing, particularly for high-volume dosage forms such as solid oral tablets. This is driven by the obvious benefits such as small footprint, batch size flexibility, the relative ...
Valentyn Mohylyuk +4 more
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Macromol, 2021 High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt ...
Amol Batra +9 more
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Predicting pharmaceutical particle size distributions using kernel mean embedding [PDF]
, 2020 In the pharmaceutical industry, the transition to continuous manufacturing of solid dosage forms is adopted by more and more companies. For these continuous processes, high-quality process models are needed.
De Beer, Thomas +3 more
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Distribution of binder in granules produced by means of twin screw granulation [PDF]
International Journal of Pharmaceutics, 2014 According to the quality by design principle processes may not remain black-boxes and full process understanding is required. The granule size distribution of granules produced via twin screw granulation is often found to be bimodal. The aim of this study was to gain a better understanding of binder distribution within granules produced via twin screw ...
Margot Fonteyne +7 more
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Continuous Melt Granulation for Taste-Masking of Ibuprofen
Pharmaceutics, 2021 Taste-masking of drugs, particularly to produce formulations for pediatric patients, can be challenging and require complex manufacturing approaches. The objective of this study was to produce taste-masked ibuprofen granules using a novel process, twin ...
Seth P. Forster, David B. Lebo
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