Dry Amorphization of Itraconazole Using Mesoporous Silica and Twin-Screw Technology [PDF]
PharmaceuticsBackground/Objectives: Amorphization of an active pharmaceutical ingredient (API) can improve its dissolution and enhance bioavailability. Avoiding solvents for drug amorphization is beneficial due to environmental issues and potential solvent residues ...
Margarethe Richter +4 more
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Continuous twin screw granulation – An advanced alternative granulation technology for use in the pharmaceutical industry [PDF]
International Journal of Pharmaceutics, 2020 Arun Butreddy +2 more
exaly +2 more sources
Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters [PDF]
PharmaceuticsHydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in
Phaedra Denduyver +2 more
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Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation [PDF]
PharmaceuticsBinder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was
Phaedra Denduyver +4 more
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Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends [PDF]
PharmaceuticsBackground/Objectives: This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability.
Rasha M. Elkanayati +6 more
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Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network [PDF]
ACS Engineering Au, 2023 Chaitanya Sampat, Rohit Ramachandran
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Regime map development for co-rotating twin screw granulation [PDF]
, 2010 Continuous granulation is an important process for the future PAT (Processes analytical technology) initiative for the FDA. Therefore it is important to investigate the relationship between operating conditions and the granules.
Tu, Wei-Da
core +7 more sources
Pharmaceutics, 2021 The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere +7 more
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Numerical analysis of the hydrodynamic behaviour of immiscible metallic alloys in twin-screw rheomixing process [PDF]
, 2006 A numerical analysis by a VOF method is presented for studying the hydrodynamic mechanisms of the rheomixing process by a twin-screw extruder (TSE). The simplified flow field is established based on a systematic analysis of flow features of immiscible ...
Tang, H, Wrobel, L C, Fan, Z
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Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation
Pharmaceutics, 2021 Experimental characterization of solid-liquid mixing for a high shear wet granulation process in a twin-screw granulator (TSG) is very challenging. This is due to the opacity of the multiphase system and high-speed processing.
Ashish Kumar +4 more
doaj +1 more source