Development of a Rapid Method for Residence Time Distribution Measurement in Twin-Screw Wet Granulation Based on Image Processing with Lab Color Space [PDF]
PharmaceuticsBackground/Objectives: In the twin-screw wet granulation (TSWG) process, accurate measurement of residence time distribution (RTD) is critical, as it characterizes material transport kinetics and mixing behavior.
Jie Zhao +3 more
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Material Transport Characteristics in Planetary Roller Melt Granulation [PDF]
Pharmaceutics, 2023 Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current
Tom Lang +3 more
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Systematic investigation of the impact of screw elements in continuous wet granulation [PDF]
International Journal of Pharmaceutics: XTwin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling.
Katharina Kiricenko +2 more
doaj +2 more sources
Dry Amorphization of Itraconazole Using Mesoporous Silica and Twin-Screw Technology [PDF]
PharmaceuticsBackground/Objectives: Amorphization of an active pharmaceutical ingredient (API) can improve its dissolution and enhance bioavailability. Avoiding solvents for drug amorphization is beneficial due to environmental issues and potential solvent residues ...
Margarethe Richter +4 more
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Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters [PDF]
PharmaceuticsHydroxypropyl methylcellulose (HPMC) is a preferred hydrophilic matrix former for controlled release formulations produced through continuous twin-screw wet granulation. However, a non-homogeneous API distribution over sieve fractions with underdosing in
Phaedra Denduyver +2 more
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Evaluation of Polyvinyl Alcohol as Binder during Continuous Twin Screw Wet Granulation [PDF]
PharmaceuticsBinder selection is a crucial step in continuous twin-screw wet granulation (TSWG), as the material experiences a much shorter residence time (2–40 s) in the granulator barrel compared to batch-wise granulation processes. Polyvinyl alcohol (PVA) 4-88 was
Phaedra Denduyver +4 more
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Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends [PDF]
PharmaceuticsBackground/Objectives: This study evaluates the efficacy of twin screw melt granulation (TSMG), and hot-melt extrusion (HME) techniques in enhancing the solubility and dissolution of simvastatin (SIM), a poorly water-soluble drug with low bioavailability.
Rasha M. Elkanayati +6 more
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Continuous twin screw granulation – An advanced alternative granulation technology for use in the pharmaceutical industry [PDF]
International Journal of Pharmaceutics, 2020 Suresh Bandari +2 more
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Optimizing Energy Efficiency of a Twin-Screw Granulation Process in Real-Time Using a Long Short-Term Memory (LSTM) Network [PDF]
ACS Engineering Au, 2023 Chaitanya Sampat, Rohit Ramachandran
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3D Population Balance Model for Continuous Twin Screw Granulator
Chemical Engineering Transactions, 2013 Continuous processes could be applied to improve cost-efficiency of pharmaceutical manufacturing that has traditionally relied on batch processing due to regulatory requirements and small lot sizes.
M. Paavola +3 more
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