Twin-screw granulation – a systematic analysis of process parameters [PDF]
British Journal of Pharmacy, 2018 Twin-screw granulation has a significant advantage over traditional granulation methods leading to the possibility of continuous manufacturing. Although this technology has drawn attention in recent years, the general understanding of the process is ...
Margarethe Richter
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Parametric Study of Residence Time Distributions and Granulation Kinetics as a Basis for Process Modeling of Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 Twin-screw wet granulation is a crucial unit operation in shifting from pharmaceutical batch to continuous processes, but granulation kinetics as well as residence times are yet poorly understood.
Timo Plath +3 more
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Effect of Mixing Elements on Granule Formation in Hot Melt Twin Screw Granulation [PDF]
Chemical Engineering Transactions, 2021 Twin screw granulation (TSG) has been applied to wet granulation, although its application in melt granulation has been more limited. This work explores potential advantages of hot melt granulation using twin screw extrusion.
Nana Sekyi +2 more
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Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder [PDF]
PharmaceuticsMethods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder.
Zoltán Márk Horváth +6 more
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A Material–Process–Equipment Integrated Design Method for Accelerating the Process Development of Twin-Screw Wet Granulation [PDF]
PharmaceuticalsBackground: Twin-screw wet granulation (TSWG) is a promising continuous manufacturing technology, featuring high operational flexibility, short residence time and consistent quality.
Liping Chen +9 more
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Emerging Technologies in Granulation: Process Analytical Technologies and Modeling Approaches in Pharmaceutical Development and Manufacturing [PDF]
PharmaceuticsIn the present review, 32 studies, published between 2020 and 2026, were reviewed to identify recent advances in pharmaceutical granulation. Emphasis is placed on the integration of real-time monitoring technologies, recent Process Analytical ...
Panagiotis Pentsis +3 more
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Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation [PDF]
Biomedicines, 2023 The continuous twin-screw wet granulation (TSWG) process was investigated and optimized with prediction-oriented I-optimal designs. The I-optimal designs can not only obtain a precise estimation of the parameters that describe the effect of five input ...
Jie Zhao, Geng Tian, Haibin Qu
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Transitioning Amiodarone Tablet Manufacturing: A Comparative Study of Batch and Continuous Wet Granulation [PDF]
PharmaceuticalsBackground/Objectives: The objective of this study was to design and optimize a continuous wet granulation process for Amiodarone hydrochloride tablets using a Design of Experiments approach.
Ju-Hyun Yoon, Chae-Won Jeon, Joo-Eun Kim
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Development of a Rapid Method for Residence Time Distribution Measurement in Twin-Screw Wet Granulation Based on Image Processing with Lab Color Space [PDF]
PharmaceuticsBackground/Objectives: In the twin-screw wet granulation (TSWG) process, accurate measurement of residence time distribution (RTD) is critical, as it characterizes material transport kinetics and mixing behavior.
Jie Zhao +3 more
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Systematic investigation of the impact of screw elements in continuous wet granulation [PDF]
International Journal of Pharmaceutics: XTwin-screw wet granulation (TSG) is a continuous manufacturing technique either for granules as final dosage form or as an intermediate before tableting or capsule filling.
Katharina Kiricenko +2 more
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