Twin-screw granulation – a systematic analysis of process parameters [PDF]
British Journal of Pharmacy, 2018 Twin-screw granulation has a significant advantage over traditional granulation methods leading to the possibility of continuous manufacturing. Although this technology has drawn attention in recent years, the general understanding of the process is ...
Margarethe Richter
doaj +3 more sources
Twin-Screw Melt Granulation for Oral Solid Pharmaceutical Products
Pharmaceutics, 2021 This article highlights the advantages of pharmaceutical continuous melt granulation by twin-screw extrusion. The different melt granulation process options and excipients are described and compared, and a case is made for expanded use of twin-screw melt
Seth P Forster, Erin Dippold
exaly +3 more sources
Twin screw granulation — A literature review [PDF]
Powder Technology, 2015 Abstract This review article addresses the currently available literature on twin screw granulation (TSG). TSG is an emerging technology rapidly gaining interest in the pharmaceutical industry as a method of continuous wet granulation. The control of the geometry of the granulator over the formation of granules and the mechanisms of granulation are ...
Neil A Rowson +2 more
exaly +2 more sources
Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing [PDF]
Pharmaceutics, 2023 The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster +4 more
doaj +2 more sources
Effect of Mixing Elements on Granule Formation in Hot Melt Twin Screw Granulation
Chemical Engineering Transactions, 2021 Twin screw granulation (TSG) has been applied to wet granulation, although its application in melt granulation has been more limited. This work explores potential advantages of hot melt granulation using twin screw extrusion.
Nana Sekyi +2 more
doaj +4 more sources
Investigating the Effects of Mixing Dynamics on Twin-Screw Granule Quality Attributes via the Development of a Physics-Based Process Map [PDF]
PharmaceuticsTwin-screw granulation (TSG) is an emerging continuous wet granulation technique that has not been widely applied in the industry due to a poor mechanistic understanding of the process.
Lalith Kotamarthy +4 more
doaj +2 more sources
Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation [PDF]
Biomedicines, 2023 Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes.
Jie Zhao, Geng Tian, Haibin Qu
doaj +2 more sources
Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation [PDF]
Biomedicines, 2023 The continuous twin-screw wet granulation (TSWG) process was investigated and optimized with prediction-oriented I-optimal designs. The I-optimal designs can not only obtain a precise estimation of the parameters that describe the effect of five input ...
Jie Zhao, Geng Tian, Haibin Qu
doaj +2 more sources
Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder [PDF]
PharmaceuticsMethods: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder.
Zoltán Márk Horváth +6 more
doaj +2 more sources
Scaling of continuous twin screw wet granulation [PDF]
AIChE Journal, 2016 Scaling rules were developed and tested for a continuous twin screw wet granulation process using three scales (11, 16, and 24 mm barrel diameter) of twin screw granulators (TSG).
Allen +19 more
core +6 more sources