Results 141 to 150 of about 533,494 (308)
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, EarlyView.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, EarlyView.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Immunology, Volume 168, Issue 1, Page 1-17, January 2023., 2023 In the past few years, the spectrum of monogenic systemic auto‐inflammatory diseases has widely expanded beyond the typical recurrent fever. Immuno‐haematological features, as cytopenias, hypogammaglobulinemia, hypereosinophilia, lymphoproliferation and immunodeficiency, have been described in association of several MSAID.
Hélène Vergneault +2 more
wiley +1 more source
Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light
Medicinal Research Reviews, EarlyView.ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva +5 more
wiley +1 more source
Journal of Clinical Periodontology, Volume 50, Issue 1, Page 102-113, January 2023., 2023 Abstract Aim To evaluate the potential role of miR‐26 family members in periodontal pathogenesis by assessing innate immune responses to periopathic bacteria and regulation of cytoskeletal organization. Materials and Methods Expression of miR‐26a‐5p and miR‐26b‐5p was quantified in gingival biopsies derived from healthy and periodontally diseased ...
Juhi R. Uttamani +10 more
wiley +1 more source
Immunomodulatory Effects of Omega‐3 Fatty Acids: Mechanistic Insights and Health Implications
Molecular Nutrition &Food Research, EarlyView.Omega‐3 fatty acids, derived from dietary sources and supplements, serve as bioactive precursors (ALA, EPA, DHA) that integrate into immune cell membranes. These fatty acids enhance cell membrane fluidity, improve immune cell communication, and modulate key transcription factors like NF‐κB.
Mahmut Bodur +3 more
wiley +1 more source
Journal of Neurochemistry, Volume 164, Issue 1, Page 57-76, January 2023., 2023 A genome‐scale model network was built for Alzheimer's disease (AD) using data from publicly available genome‐wide association studies in humans, and transcriptomics and proteomics data from brain tissue from mouse models of AD. The derived network was characterized by gene ontology, transcription factor analysis, and pathway and cell‐type enrichment ...
Monica Emili Garcia‐Segura +9 more
wiley +1 more source
Molecular Nutrition &Food Research, EarlyView.Pomegranate extracts contain polyphenols with: anti‐angiogenic properties inhibiting angiogenesis in Cancer resulting in decreased cancer growth; pro‐angiogenic properties promoting angiogenesis in chronic wound healing hence increasing the healing process ABSTRACT Angiogenesis plays a critical role in both tumor progression and wound healing.
Anna Eleonora Caprifico +8 more
wiley +1 more source
Molecular Nutrition &Food Research, EarlyView.Resveratrol and pterostilbene reduced the steatotic status of animals fed a high‐fat, high‐sucrose diet, involving differential and specific mechanisms of action for each stilbene. Thus, changes in riboflavin metabolism, nicotinamide mononucleotide metabolism, or in the LysoPC(18:1)‐mediated effects contribute to the specific actions of pterostilbene ...
Alfredo Fernández‐Quintela +5 more
wiley +1 more source