Antimicrobial activity of clofazimine is not dependent on mycobacterial C-type phospholipases [PDF]
Journal of Antimicrobial Chemotherapy, 2004 We have used a phospholipase C (PLC)-deletion mutant (plcABC) of the H37Rv strain of Mycobacterium tuberculosis (MTB), as well as a plcA-insertion mutant of Mycobacterium smegmatis, to investigate the possible involvement of PLCs in clofazimine-mediated ...
M C Bopape +5 more
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Endogenous phospholipase A2 inhibitors in snakes: a brief overview
Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation.
Patrícia Cota Campos +3 more
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Frontiers in Plant Science, 2013 Phosphoinositide-dependent phospholipases C (PI-PLCs) are activated in response to various stimuli. They utilize substrates provided by type III-Phosphatidylinositol-4 kinases (PI4KIII) to produce inositol triphosphate and diacylglycerol (DAG) that is ...
Nabila eDjafi +12 more
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Toxins, 2016 Venoms of most Russian viper species are poorly characterized. Here, by quantitative chromato-mass-spectrometry, we analyzed protein and peptide compositions of venoms from four Vipera species (V. kaznakovi, V. renardi, V. orlovi and V.
Sergey I. Kovalchuk +4 more
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Inhibition of c-fos transcription and phosphorylation of the serum response factor by an inhibitor of phospholipase C-type reactions. [PDF]
Molecular and Cellular Biology, 1990 Phospholipase C activity is necessary for transcriptional c-fos activation by providing diacylglycerol as an activator of protein kinase C. We found that transcriptional activation of c-fos and the phosphorylation of its major transcription factor were inhibited by tricyclodecan-9-yl xanthogenate, which blocks phospholipase C-type reactions ...
Gunnar Schalasta, Clemens Doppler
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Hydrolysis of Phospholipids by phospholipase C in intact cells of wild‐type and envelope mutants of Escherichia coli K12 [PDF]
FEBS Letters, 1981 Zdena Stárková +2 more
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Yeast Pgc1p (YPL206c) Controls the Amount of Phosphatidylglycerol via a Phospholipase C-type Degradation Mechanism [PDF]
Journal of Biological Chemistry, 2008 The product of the open reading frame YPL206c, Pgc1p, of the yeast Saccharomyces cerevisiae displays homology to bacterial and mammalian glycerophosphodiester phosphodiesterases. Deletion of PGC1 causes an accumulation of the anionic phospholipid, phosphatidylglycerol (PG), especially under conditions of inositol limitation.
Mária Šimočková +4 more
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Properties of Clostridium Perfringens (Welch II) Type-A -Toxin (Phospholipase c) Purified By Electrofocusing [PDF]
Journal of Medical Microbiology, 1974 SUMMARY Clostridium perfringens type-A α-toxin (phospholipase C) was purified on a preparative scale by a simple, rapid, two-stage procedure involving precipitation of culture-supernatant fluids with ammonium sulphate at 35 to 50% saturation, followed by isoelectric focusing in a pH 4·6 gradient.
C. J. Smyth, J. P. Arbuthnott
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Isolation and characterization of a γ-type phosphoinositide-specific phospholipase C (PLC-γ2) [PDF]
Biochemical Journal, 1990 A novel bovine spleen phosphoinositide-specific phospholipase C (PLC) has been identified with respect to immunoreactivity with four independent antibodies against each of the PLC isoenzymes, and purified to near homogeneity by sequential column chromatography.
Yoshimi Homma +4 more
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Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons [PDF]
The Journal of Neuroscience, 2000 Although presynaptic localization of mGluR7 is well established, the mechanism by which the receptor may control Ca2+channels in neurons is still unknown. We show here that cultured cerebellar granule cells express native metabotropic glutamate receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was also expressed in cell bodies.
Julie Perroy +5 more
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