Phylogenetic analysis of phospholipase C genes from Clostridium perfringens types A to E and Clostridium novyi [PDF]
Journal of Bacteriology, 1995 The phylogenetic interrelationships between strains of 5 toxin types (A to E) of Clostridium perfringens were examined by analysis of differences in the nucleotide sequences of phospholipase C genes (plc genes) among 10 strains, including 3 strains for which the plc gene sequences have been previously reported.
Ken‐Ichiro Tsutsui +7 more
openalex +4 more sources
Cloning of the Human Phospholipase C-γ1 Promoter and Identification of a DR6-type Vitamin D-responsive Element [PDF]
Journal of Biological Chemistry, 1997 The 5'-flanking region of the human phospholipase C-gamma1 gene was isolated from a human P1 genomic DNA library. The S1-nuclease mapping and primer extension analysis revealed that there is a single transcriptional start site located at 135 bases upstream from the translation start codon in the human phospholipase C-gamma1 gene.
Zhongjian Xie, Daniel D. Bikle
openalex +4 more sources
Production of Phospholipase C (Alpha-toxin), Haemolysins and Lethal Toxins by Clostridium perfringens Types A to D [PDF]
Journal of General Microbiology, 1976 To obtain high yields of extracellular enzymes and toxins for immunological analysis, type culture collection strains of Clostridium perfringens types A to D and 28 fresh isolates of C. perfringens type A from humans were grown in fermenters under controlled conditions in a pre-reduced proteose peptone medium.
R. Möllby +4 more
openalex +4 more sources
Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin [PDF]
Cellular & Molecular Biology LettersThe skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell ...
Michał Biernacki +1 more
doaj +2 more sources
Phenotypes of Pain Behavior in Phospholipase C-Related but Catalytically Inactive Protein Type 1 Knockout Mice [PDF]
Molecular Pain, 2011 Phospholipase C-related inactive protein (PRIP) plays important roles in trafficking to the plasma membrane of GABAA receptor, which is involved in the dominant inhibitory neurotransmission in the spinal cord and plays an important role in nociceptive transmission. However, the role of PRIP in pain sensation remains unknown.
Keisuke Migita +6 more
openalex +6 more sources
Collagen type IV stimulates an increase in intracellular Ca2+ in pancreatic acinar cells via activation of phospholipase C [PDF]
Biochemical Journal, 1994 Intracellular Ca2+ responses to extracellular matrix molecules were studied in suspensions of pancreatic acinar cells loaded with Fura-2. Collagen type I, laminin, fibrinogen and fibronectin were unable to raise cytosolic free Ca2+ concentration ([Ca2+]i), whereas collagen type IV, at concentrations from 5 to 50 micrograms/ml, significantly increased ...
László Somogyi +3 more
openalex +4 more sources
Purification of two distinct types of phosphoinositide-specific phospholipase C from rat liver. Enzymological and structural studies [PDF]
Biochemical Journal, 1988 Two kinds of phosphoinositide-specific phospholipase C (PLC) were purified from rat liver by acid precipitation and several steps of column chromatography. About 50% of the activity could be precipitated when the pH of the liver homogenate was lowered to pH 4.7. The redissolved precipitate yielded two peaks, PLC I and PLC II, in an Affi-gel Blue column,
Osamu Nakanishi +5 more
openalex +4 more sources
Autologous Extracellular Cytochrome c Is an Endogenous Ligand for Leucine-rich α2-Glycoprotein and β-Type Phospholipase A2 Inhibitor [PDF]
Journal of Biological Chemistry, 2010 Beta-type phospholipase A(2) inhibitory protein (PLIbeta) from the serum of the venomous snake Gloydius brevicaudus neutralizes basic phospholipase A(2) (PLA(2)) from its own venom, and it has 33% sequence homology with human leucine-rich alpha(2)-glycoprotein (LRG), which has been recently reported to bind cytochrome c (Cyt c) (Cummings, C., Walder, J.
Ryoichi Shirai 白井 僚一 +4 more
openalex +4 more sources
Hydrolysis of Phospholipids by phospholipase C in intact cells of wild‐type and envelope mutants of Escherichia coli K12 [PDF]
FEBS Letters, 1981 Zdena Stárková +2 more
openalex +5 more sources
American Journal of Physiology-Endocrinology and Metabolism, 2008 The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTH1R) belongs to family B of seven-transmembrane-spanning receptors and is activated by PTH and PTHrP. Upon PTH stimulation, the rat PTH1R becomes phosphorylated at seven serine residues.
Susanne U. Miedlich +1 more
openalex +5 more sources