Results 51 to 60 of about 1,747,398 (243)

Identification and Purification of a Novel Receptor for Secretory Phospholipase A2 in Porcine Cerebral Cortex*

Journal of Biological Chemistry, 1999
A specific phospholipase A2receptor from porcine cerebral cortex has been characterized (K d = 145 nm,B max = 0.4 pmol/mg membrane protein) by using a radioiodinated derivative of ammodytoxin C (AtxC), a snake venom presynaptically neurotoxic group IIA ...
A. Čopič, N. Vucemilo, F. Gubensek, I. Križaj   +3 more
semanticscholar   +1 more source

A High Affinity Acceptor for Phospholipase A2 with Neurotoxic Activity Is a Calmodulin*

Journal of Biological Chemistry, 2001
One of the high affinity binding proteins for ammodytoxin C, a snake venom presynaptically neurotoxic phospholipase A2, has been purified from porcine cerebral cortex and characterized.
J. Šribar, A. Čopič, A. Pariš, N. Sherman, F. Gubensek, J. Fox, I. Križaj   +6 more
semanticscholar   +1 more source

Characterization of Plp, a phosphatidylcholine-specific phospholipase and hemolysin of Vibrio anguillarum [PDF]

, 2014
Background: Vibrio anguillarum is the causative agent of vibriosis in fish. Several extracellular proteins secreted by V. anguillarum have been shown to contribute to virulence.
Li, Ling, Mou, Xiangyu, Nelson, David R
core   +6 more sources

Natural Compounds Interacting with Nicotinic Acetylcholine Receptors: From Low-Molecular Weight Ones to Peptides and Proteins

Toxins, 2015
Nicotinic acetylcholine receptors (nAChRs) fulfill a variety of functions making identification and analysis of nAChR subtypes a challenging task. Traditional instruments for nAChR research are d-tubocurarine, snake venom protein α-bungarotoxin (α-Bgt ...
Denis Kudryavtsev, Irina Shelukhina, Catherine Vulfius, Tatyana Makarieva, Valentin Stonik, Maxim Zhmak, Igor Ivanov, Igor Kasheverov, Yuri Utkin, Victor Tsetlin   +9 more
doaj   +1 more source

Venom Proteomics of Trimeresurus gracilis, a Taiwan-Endemic Pitviper, and Comparison of Its Venom Proteome and VEGF and CRISP Sequences with Those of the Most Related Species

Toxins, 2023
Trimeresurus gracilis is an endemic alpine pitviper in Taiwan with controversial phylogeny, and its venom proteome remains unknown. In this study, we conducted a proteomic analysis of T.
Tsz-Chun Tse, Inn-Ho Tsai, Yuen-Ying Chan, Tein-Shun Tsai   +3 more
doaj   +1 more source

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity.

Biochemistry, 2006
Several snake venom secreted phospholipases A2 (sPLA2s) including OS2 exert a variety of pharmacological effects ranging from central neurotoxicity to anti-HIV activity by mechanisms that are not yet fully understood.
M. Rouault, L. Rash, P. Escoubas, É. Boilard, James M. Bollinger, B. Lomonte, T. Maurin, Carole Guillaume, S. Canaan, C. Deregnaucourt, J. Schrével, A. Doglio, J. Gutiérrez, M. Lazdunski, M. Gelb, G. Lambeau   +15 more
semanticscholar   +1 more source

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. [PDF]

, 2017
Cytosolic phospholipase A2 (GIVA cPLA2) is the only PLA2 that exhibits a marked preference for hydrolysis of arachidonic acid containing phospholipid substrates releasing free arachidonic acid and lysophospholipids and giving rise to the generation of ...
Barbayianni, Efrosini, Dennis, Edward A, Galiatsatou, Gerasimia, Kokotos, George, Kokotou, Maroula G, Koutoulogenis, Giorgos, Limnios, Dimitris, Magrioti, Victoria, Mouchlis, Varnavas D, Navratil, Aaron, Satpathy, Banita   +10 more
core   +1 more source

Secreted phospholipases A2 in hereditary angioedema with C1-inhibitor deficiency [PDF]

, 2018
BackgroundHereditary angioedema (HAE) caused by deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein (C1-INH-HAE) is a disabling, potentially fatal condition characterized by recurrent episodes of swelling. We have recently found that
Andrea Zanichelli, Angelica Petraroli, Anne Lise Ferrara, Chiara Suffritti, Francesco Borriello, Francesco Borriello, Francescopaolo Granata, Gianni Marone, Gianni Marone, Gilda Varricchi, Gérard Lambeau, Henriette Farkas, Marco Cicardi, Maria Bova, Maria Rosaria Galdiero, Nóra Veszeli, Stefania Loffredo   +16 more
core   +3 more sources

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J., Gay, Claudia Carolina, Pla, Davinia, Sanz, Libia   +3 more
core   +5 more sources

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. [PDF]

, 1994
Intracellular pathways leading from membrane receptor engagement to apoptotic cell death are still poorly characterized. We investigated the intracellular signaling generated after cross-linking of CD95 (Fas/Apo-1 antigen), a broadly expressed cell ...
Azuma, M, Cifone, MG, De Maria, R, Lanier, LL, Rippo, MR, Roncaioli, P, Santoni, A, Testi, R   +7 more
core   +2 more sources