Results 211 to 220 of about 1,669,550 (354)

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

RACK1 Associates With STING to Promote Type I Interferon Activation and Inhibit Pseudorabies Virus Infection. [PDF]

Transbound Emerg Dis
Li Y, Liu Y, Dai Y, Niu J, Li G, Yu X, Wan C, Fang R, Ye C.   +8 more
europepmc   +1 more source

SRC FAMILY KINASE MEMBERS MEDIATE TYPE I INTERFERON PRODUCTION BY PLASMACYTOID DENDRITIC CELLS

, 2015
Simone Dallari
openalex   +2 more sources

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Correction: Type I Interferon: Potential Therapeutic Target for Psoriasis?

PLoS ONE, 2009
Yihong Yao, Laura Richman, Chris Morehouse, Melissa de los Reyes, Brandon W. Higgs, Anmarie Boutrin, Barbara White, Anthony Coyle, James Krueger, Peter A. Kiener, Bahija Jallal   +10 more
doaj   +3 more sources

The Type I Interferon Axis in Systemic Autoimmune Diseases: From Molecular Pathways to Targeted Therapy. [PDF]

Biomolecules
Ishihara R, Watanabe R, Shiomi M, Fujita Y, Katsushima M, Fukumoto K, Yamada S, Hashimoto M.   +7 more
europepmc   +1 more source

Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells

, 2021
Carolina R. Melo‐Silva, Pedro Alves-Peixoto, Natasha Heath, Lingjuan Tang, Brian Montoya, Cory J. Knudson, Colby Stotesbury, M C C Ferez, Eric B. Wong, Luis J. Sigal   +9 more
openalex   +2 more sources

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Autonomous STING signaling in Purkinje cells drives neurodegeneration independent of type I interferon. [PDF]

Cell Rep
Yang K, Dunn M, Torres-Ramirez G, Dobbs N, Shakkottai VG, Yan N.   +5 more
europepmc   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source