SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70
Cellular & Molecular Immunology, 2020 COVID-19 is caused by SARS-CoV-2. As of July 16th, 2020, there were 13,579,581 diagnosed cases and 584,782 deaths attributed to COVID-19 reported globally (https://coronavirus.jhu.edu/map. html). Unfortunately, there is still no effective drug or vaccine
He-wei Jiang +12 more
semanticscholar +1 more source
EHMT1 Protein Binds to Nuclear Factor-κB p50 and Represses Gene Expression [PDF]
, 2012 Transcriptional homeostasis relies on the balance between positive and negative regulation of gene transcription. Methylation of histone H3 lysine 9 (H3K9) is commonly correlated with gene repression.
Baltimore, David +3 more
core +1 more source
Phleboviruses and the Type I Interferon Response
Viruses, 2016 The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly ...
Jennifer Deborah Wuerth +1 more
doaj +1 more source
Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. [PDF]
PLoS ONE, 2014 The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease ...
Daniel P Beiting +8 more
doaj +1 more source
Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo
Pathogens, 2022 Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis.
Johannes Schwerk +14 more
doaj +1 more source
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.
Journal of Clinical Investigation, 2020 Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we have demonstrated a potent IFN immunogenicity of nucleic acid (NA)-containing amyloid fibrils in the periphery.
Ethan R. Roy +15 more
semanticscholar +1 more source
Paramyxovirus V proteins interact with the RNA helicase LGP2 to inhibit RIG-I-dependent interferon induction [PDF]
, 2012 This work was supported by the Wellcome Trust (grant AL087751/B)RIG-I and mda-5 are activated by viral RNA and stimulate type I interferon production. Laboratory of genetics and physiology 2 (LGP2) shares homology with RIG-I and mda-5 but lacks the CARD ...
Childs, Kay +2 more
core +1 more source
Hantavirus Regulation of Type I Interferon Responses
Advances in Virology, 2012 Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early ...
Valery Matthys, Erich R. Mackow
doaj +1 more source
medRxiv, 2021 Impairment of type I interferon (IFN‐I) immunity has been reported in critically ill COVID‐19 patients. This defect can be explained in a subset of patients by the presence of circulating autoantibodies (auto‐Abs) against IFN‐I. We set out to improve the
David Goncalves +12 more
semanticscholar +1 more source
Type I/II interferon in HIV-1-infected patients: expression in gut mucosa and in peripheral blood mononuclear cells and its modification upon probiotic supplementation [PDF]
, 2018 Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic ...
Antonelli, Guido +10 more
core +1 more source