Results 31 to 40 of about 1,669,550 (354)

Phleboviruses and the Type I Interferon Response

Viruses, 2016
The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly ...
Jennifer Deborah Wuerth, Friedemann Weber   +1 more
doaj   +1 more source

Type I Interferon Induction in Cutaneous DNA Damage Syndromes

Frontiers in Immunology, 2021
Type I interferons (IFNs) as part of the innate immune system have an outstanding importance as antiviral defense cytokines that stimulate innate and adaptive immune responses.
Benjamin Klein, Claudia Günther
doaj   +1 more source

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. [PDF]

PLoS ONE, 2014
The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease ...
Daniel P Beiting, Lucia Peixoto, Natalia S Akopyants, Stephen M Beverley, E John Wherry, David A Christian, Christopher A Hunter, Igor E Brodsky, David S Roos   +8 more
doaj   +1 more source

Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.

Journal of Clinical Investigation, 2020
Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we have demonstrated a potent IFN immunogenicity of nucleic acid (NA)-containing amyloid fibrils in the periphery.
Ethan R. Roy, Baiping Wang, Ying-Wooi Wan, G. Chiu, Allysa L Cole, Zhuoran Yin, Nicholas E. Propson, Yin Xu, J. Jankowsky, Zhandong Liu, V. Lee, J. Trojanowski, S. Ginsberg, O. Butovsky, Hui Zheng, Wei Cao   +15 more
semanticscholar   +1 more source

Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo

Pathogens, 2022
Gammaherpesviruses, such as Epstein-Barr virus and Kaposi’s sarcoma-associated herpesvirus, are important human pathogens involved in lymphoproliferative disorders and tumorigenesis.
Johannes Schwerk, Lucas Kemper, Kendra A. Bussey, Stefan Lienenklaus, Siegfried Weiss, Luka Čičin-Šain, Andrea Kröger, Ulrich Kalinke, Christopher M. Collins, Samuel H. Speck, Martin Messerle, Dagmar Wirth, Melanie M. Brinkmann, Hansjörg Hauser, Mario Köster   +14 more
doaj   +1 more source

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

Cellular & Molecular Immunology, 2020
COVID-19 is caused by SARS-CoV-2. As of July 16th, 2020, there were 13,579,581 diagnosed cases and 584,782 deaths attributed to COVID-19 reported globally (https://coronavirus.jhu.edu/map. html). Unfortunately, there is still no effective drug or vaccine
He-wei Jiang, Hai-nan Zhang, Q.-f. Meng, Jia-Xuan Xie, Yang Li, Hong Chen, Yun-xiao Zheng, Xue-ning Wang, H. Qi, Jing Zhang, Peihui Wang, Ze-Guang Han, S. Tao   +12 more
semanticscholar   +1 more source

Type I interferon, anti-interferon antibodies, and COVID-19 [PDF]

The Lancet Rheumatology, 2021
Author(s): Calabrese, Leonard H; Winthrop, Kevin; Strand, Vibeke; Yazdany, Jinoos; Walter, Jolan ...
Calabrese, Leonard H, Winthrop, Kevin, Strand, Vibeke, Yazdany, Jinoos, Walter, Jolan E   +4 more
openaire   +4 more sources

Hantavirus Regulation of Type I Interferon Responses

Advances in Virology, 2012
Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early ...
Valery Matthys, Erich R. Mackow
doaj   +1 more source

Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells

Viruses, 2012
Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules,
Xiuqing Wang, Jane Christopher-Hennings
doaj   +1 more source

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Nature Communications, 2022
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death.
Nikaïa Smith, C. Posseme, V. Bondet, Jamie A. Sugrue, L. Townsend, B. Charbit, V. Rouilly, Violaine Saint-André, Tom Dott, Andre Rodriguez Pozo, N. Yatim, O. Schwartz, Minerva Cervantes-Gonzalez, J. Ghosn, Paul Bastard, J. Casanova, T. Szwebel, B. Terrier, N. Conlon, C. O’Farrelly, C. N. Cheallaigh, Nollaig M. Bourke, D. Duffy   +22 more
semanticscholar   +1 more source