Results 41 to 50 of about 1,669,550 (354)

Type I interferon in rheumatic diseases [PDF]

Nature Reviews Rheumatology, 2018
The type I interferon pathway has been implicated in the pathogenesis of a number of rheumatic diseases, including systemic lupus erythematosus, Sjögren syndrome, myositis, systemic sclerosis, and rheumatoid arthritis. In normal immune responses, type I interferons have a critical role in the defence against viruses, yet in many rheumatic diseases ...
Theresa L Wampler, Muskardin, Timothy B, Niewold   +1 more
openaire   +2 more sources

Tick-Borne Flaviviruses and the Type I Interferon Response

Viruses, 2018
Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Richard Lindqvist, Arunkumar Upadhyay, Anna K. Överby   +2 more
doaj   +1 more source

Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade

Gut, 2021
Objective Our goals were to evaluate the antitumour efficacy of Lactobacillus rhamnosus GG (LGG) in combination with immune checkpoint blockade (ICB) immunotherapies on tumour growth and to investigate the underlying mechanisms.
Wei Si, H. Liang, Jason Bugno, Qi Xu, Xing-chen Ding, Kaiting Yang, Yanbin Fu, R. Weichselbaum, Xin Zhao, Liangliang Wang   +9 more
semanticscholar   +1 more source

Dysregulation of type I interferon responses in COVID-19

Nature reviews. Immunology, 2020
Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted.
D. Acharya, Guanqun Liu, Michaela U. Gack   +2 more
semanticscholar   +1 more source

Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV

Journal of Virology, 2020
With the ongoing outbreak of COVID-19, differences between SARS-CoV-2 and the original SARS-CoV could be leveraged to inform disease progression and eventual treatment options.
K. Lokugamage, Adam Hage, M. de Vries, Ana M. Valero-Jimenez, Craig Schindewolf, Meike Dittmann, Ricardo Rajsbaum, Vineet D. Menachery   +7 more
semanticscholar   +1 more source

Fine-Tuning of Type I Interferon Response by STAT3

Frontiers in Immunology, 2019
Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai, Li-Mei Pai, Li-Mei Pai, Li-Mei Pai, Chien-Kuo Lee   +4 more
doaj   +1 more source

Investigation of type I interferon responses in ANCA-associated vasculitis

Scientific Reports, 2021
Type I interferon (IFN) dysregulation is a major contributory factor in the development of several autoimmune diseases, termed type I interferonopathies, and is thought to be the pathogenic link with chronic inflammation in these conditions.
Isabella Batten, Mark W. Robinson, Arthur White, Cathal Walsh, Barbara Fazekas, Jason Wyse, Antonia Buettner, Suzanne D’Arcy, Emily Greenan, Conor C. Murphy, Zoe Wigston, Joan Ní Gabhann-Dromgoole, Edward M. Vital, Mark A. Little, Nollaig M. Bourke   +14 more
doaj   +1 more source

Antibodies against type I interferon: detection and association with severe clinical outcome in COVID‐19 patients

medRxiv, 2021
Impairment of type I interferon (IFN‐I) immunity has been reported in critically ill COVID‐19 patients. This defect can be explained in a subset of patients by the presence of circulating autoantibodies (auto‐Abs) against IFN‐I. We set out to improve the
David Goncalves, Mehdi Mezidi, Paul Bastard, M. Perret, K. Saker, N. Fabien, Rémi Pescarmona, C. Lombard, T. Walzer, J. Casanova, A. Belot, J. Richard, S. Trouillet-Assant   +12 more
semanticscholar   +1 more source

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

medRxiv, 2020
Background: Coronavirus disease 2019 (Covid-19) is a major global threat that has already caused more than 100,000 deaths worldwide. It is characterized by distinct patterns of disease progression implying a diverse host immune response.
J. Hadjadj, N. Yatim, L. Barnabei, A. Corneau, J. Boussier, H. Péré, B. Charbit, V. Bondet, C. Chenevier-Gobeaux, P. Breillat, Nicolas Carlier, R. Gauzit, C. Morbieu, F. Pène, N. Marin, N. Roche, T. Szwebel, Nikaïa Smith, S. Merkling, J. Treluyer, D. Veyer, L. Mouthon, C. Blanc, P. Tharaux, F. Rozenberg, A. Fischer, D. Duffy, F. Rieux-Laucat, S. Kernéis, B. Terrier   +29 more
semanticscholar   +1 more source

Type I interferon responsive microglia shape cortical development and behavior

Cell, 2021
Microglia are brain resident phagocytes that can engulf synaptic components and extracellular matrix as well as whole neurons. However, whether there are unique molecular mechanisms that regulate these distinct phagocytic states is unknown.
Caroline C. Escoubas, Leah C. Dorman, Phi T. Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R Anderson, Beatriz Cuevas, I. Vainchtein, Nicholas J. Silva, Yinghong Xiao, Peter V. Lidsky, Ellen Y. Wang, Sunrae E. Taloma, Hiromi Nakao-Inoue, B. Schwer, R. Andino, T. Nowakowski, A. Molofsky   +17 more
semanticscholar   +1 more source