Results 41 to 50 of about 1,881,665 (353)

Post-Transcriptional Control of Type I Interferon Induction by Porcine Reproductive and Respiratory Syndrome Virus in Its Natural Host Cells

Viruses, 2012
Porcine reproductive and respiratory syndrome virus (PRRSV) is not only a poor inducer of type I interferon but also inhibits the efficient induction of type I interferon by porcine transmissible gastroenteritis virus (TGEV) and synthetic dsRNA molecules,
Xiuqing Wang, Jane Christopher-Hennings
doaj   +1 more source

Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells [PDF]

, 2008
The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN).
Bauer, Carla M.T., DeWitte-Orr, Stephanie J., Hornby, Kyle R., Lichty, Brian D., Mossman, Karen L., Stämpfli, Martin R., Zavitz, Caleb C.J.   +6 more
core   +2 more sources

Mechanisms of immune regulation by the placenta: Role of type I interferon and interferon‐stimulated genes signaling during pregnancy *

Immunological Reviews, 2022
Pregnancy is a unique condition where the maternal immune system is continuously adapting in response to the stages of fetal development and signals from the environment.
Jiahui Ding, A. Maxwell, Nicholas K Adzibolosu, Anna Hu, Y. You, A. Liao, G. Mor   +6 more
semanticscholar   +1 more source

The interferon-induced exonuclease ISG20 exerts antiviral activity through upregulation of type I interferon response proteins [PDF]

, 2018
The host immune responses to infection lead to the production of type I interferon (IFN), and the upregulation of interferon-stimulated genes (ISGs) reduces virus replication and virus dissemination within a host.
Diamond, Michael S, Klimstra, William B, Lucas, Tiffany M, Ryman, Kate D, Sun, Chengqun, Trobaugh, Derek W, Weiss, Christopher M   +6 more
core   +2 more sources

Type I Interferon Susceptibility Distinguishes SARS-CoV-2 from SARS-CoV

Journal of Virology, 2020
With the ongoing outbreak of COVID-19, differences between SARS-CoV-2 and the original SARS-CoV could be leveraged to inform disease progression and eventual treatment options.
K. Lokugamage, Adam Hage, M. de Vries, Ana M. Valero-Jimenez, Craig Schindewolf, Meike Dittmann, Ricardo Rajsbaum, Vineet D. Menachery   +7 more
semanticscholar   +1 more source

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity

Nature Communications, 2022
Host immunity to infection with SARS-CoV-2 is highly variable, dictating diverse clinical outcomes ranging from asymptomatic to severe disease and death.
Nikaïa Smith, C. Posseme, V. Bondet, Jamie A. Sugrue, L. Townsend, B. Charbit, V. Rouilly, Violaine Saint-André, Tom Dott, Andre Rodriguez Pozo, N. Yatim, O. Schwartz, Minerva Cervantes-Gonzalez, J. Ghosn, P. Bastard, J. Casanova, T. Szwebel, B. Terrier, N. Conlon, C. O’Farrelly, C. N. Cheallaigh, Nollaig M. Bourke, D. Duffy   +22 more
semanticscholar   +1 more source

The interferon-inducible antiviral protein Daxx is not essential for interferon-mediated protection against avian sarcoma virus [PDF]

, 2014
BACKGROUND: The antiviral protein Daxx acts as a restriction factor of avian sarcoma virus (ASV; Retroviridae) in mammalian cells by promoting epigenetic silencing of integrated proviral DNA.
Anna Skalka, Kelsey A Haugh, Natalia Shalginskikh, Richard A Katz, Shoko Nogusa, Siddharth Balachandran   +5 more
core   +1 more source

Tick-Borne Flaviviruses and the Type I Interferon Response

Viruses, 2018
Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Richard Lindqvist, Arunkumar Upadhyay, Anna K. Överby   +2 more
doaj   +1 more source

Dysregulation of type I interferon responses in COVID-19

Nature reviews. Immunology, 2020
Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted.
D. Acharya, Guanqun Liu, Michaela U. Gack   +2 more
semanticscholar   +1 more source

Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus [PDF]

, 2016
The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with ...
Budd, Ralph C., Buskiewicz, Iwona A., Crow, Mary K., Hartley, Richard C., Huber, Sally A., Kelly, Ryan, Koenig, Andreas, Montgomery, Theresa, Murphy, Michael P., Perl, Andras, Yasewicz, Elizabeth C.   +10 more
core   +1 more source