Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection [PDF]
, 2017 The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in
Ashkar, Ali A +11 more
core +2 more sources
Fine-Tuning of Type I Interferon Response by STAT3
Frontiers in Immunology, 2019 Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai +4 more
doaj +1 more source
Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus [PDF]
, 2016 The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with ...
Budd, Ralph C. +10 more
core +1 more source
Type I Interferons in Host Defense [PDF]
Immunity, 2006 Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to viruses and other intracellular infections. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of type I IFNs have been identified and characterized.
Stetson, Daniel B., Medzhitov, Ruslan
openaire +2 more sources
Truncation of the NS1 protein converts a low pathogenic avian influenza virus into a strong interferon inducer in duck cells [PDF]
, 2010 The NS1 protein of influenza A viruses is known as a nonessential virulence factor inhibiting type I interferon (IFN) production in mammals and in chicken cells. Whether NS1 inhibits the induction of type I IFNs in duck cells is currently unknown.
Guérin, Jean-Luc +3 more
core +1 more source
Type I interferon induces cancer stem cells-mediated chemotherapy resistance
OncoImmunology, 2022 In a recent study in Nature Immunology, Musella et al. demonstrate that suboptimal type I interferon (IFN-I) signaling in tumors undergoing immunogenic cell death (ICD) facilitates the accumulation of cancer stem cells (CSCs) by triggering the epigenetic
Mara De Martino, Claire Vanpouille-Box
doaj +1 more source
Type I interferons in infectious disease [PDF]
Nature Reviews Immunology, 2015 Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses.
Finlay McNab +4 more
openaire +2 more sources
The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]
, 2016 Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S +4 more
core +2 more sources
Type I Interferon Induction in Cutaneous DNA Damage Syndromes
Frontiers in Immunology, 2021 Type I interferons (IFNs) as part of the innate immune system have an outstanding importance as antiviral defense cytokines that stimulate innate and adaptive immune responses.
Benjamin Klein, Claudia Günther
doaj +1 more source
Regulation of type I interferon responses [PDF]
Nature Reviews Immunology, 2013 Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. Canonical type I IFN signalling activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway, leading to transcription of IFN-stimulated genes (ISGs).
Lionel B, Ivashkiv, Laura T, Donlin
openaire +2 more sources