Results 61 to 70 of about 1,875,952 (301)

Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade

Gut, 2021
Objective Our goals were to evaluate the antitumour efficacy of Lactobacillus rhamnosus GG (LGG) in combination with immune checkpoint blockade (ICB) immunotherapies on tumour growth and to investigate the underlying mechanisms.
Wei Si, H. Liang, Jason Bugno, Qi Xu, Xing-chen Ding, Kaiting Yang, Yanbin Fu, R. Weichselbaum, Xin Zhao, Liangliang Wang   +9 more
semanticscholar   +1 more source

Fine-Tuning of Type I Interferon Response by STAT3

Frontiers in Immunology, 2019
Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai, Li-Mei Pai, Li-Mei Pai, Li-Mei Pai, Chien-Kuo Lee   +4 more
doaj   +1 more source

Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

medRxiv, 2020
Background: Coronavirus disease 2019 (Covid-19) is a major global threat that has already caused more than 100,000 deaths worldwide. It is characterized by distinct patterns of disease progression implying a diverse host immune response.
J. Hadjadj, N. Yatim, L. Barnabei, A. Corneau, J. Boussier, H. Péré, B. Charbit, V. Bondet, C. Chenevier-Gobeaux, P. Breillat, Nicolas Carlier, R. Gauzit, C. Morbieu, F. Pène, N. Marin, N. Roche, T. Szwebel, Nikaïa Smith, S. Merkling, J. Treluyer, D. Veyer, L. Mouthon, C. Blanc, P. Tharaux, F. Rozenberg, A. Fischer, D. Duffy, F. Rieux-Laucat, S. Kernéis, B. Terrier   +29 more
semanticscholar   +1 more source

The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]

, 2016
Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S, Farzan, Michael, Gorman, Matthew J, Hyde, Jennifer L, Poddar, Subhajit   +4 more
core   +2 more sources

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

The type I interferon response in COVID-19: implications for treatment

Nature reviews. Immunology, 2020
Despite early reports to the contrary, there is increasing evidence that patients with severe COVID-19 have a robust type I interferon response, which contrasts with the delayed, possibly suppressed, interferon response seen early in infection.
Jeong Seok Lee, E. Shin
semanticscholar   +1 more source

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection [PDF]

, 2017
The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in
Ashkar, Ali A, Barra, Nicole G, Chen, Branson, Chew, Marianne V, Jordana, Manel, Lee, Amanda J, Mack, Matthias, Mossman, Karen L, Nham, Tina, Rooijen, Nico van, Schreiber, Robert D, Shenouda, Mira M   +11 more
core   +2 more sources

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

Social Science Research Network, 2020
Israelow et al. show that AAV-mediated expression of human ACE2 allows for SARS-CoV-2 infection and disease investigation in mice. This pathology is in part driven by type I interferon signaling, which recruits inflammatory immune cells without aborting ...
Benjamin Israelow, E. Song, Tianyang Mao, Peiwen Lu, A. Meir, Feimei Liu, M. M. Alfajaro, Jin Wei, Huiping Dong, R. Homer, A. Ring, Craig B. Wilen, A. Iwasaki   +12 more
semanticscholar   +1 more source

Type I interferons in infectious disease [PDF]

Nature Reviews Immunology, 2015
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses.
Finlay McNab, Katrin Mayer-Barber, Alan Sher, Andreas Wack, Anne O'Garra   +4 more
openaire   +2 more sources

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors. [PDF]

, 2011
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans.
A Alcami, A Alcami, A Harari, A Harari, A Subramanian, Abdelali Filali-Mouhim, AD Bins, AJ McNeil, Alexandre Harari, Anke Redeker, Antonio Lanzavecchia, B Perdiguero, Beatriz Perdiguero, Bertram L. Jacobs, Carmen E. Gomez, CE Gomez, CE Gomez, CE Gomez, CF Ockenhouse, CJM Melief, Clive Gray, Cornelis J. M. Melief, D Chaussabel, D Gaucher, David M. Koelle, DD Richman, DH O'Connor, DR Burton, E Paoletti, E Tryniszewska, Elias K. Haddad, Esther D. Quakkelaar, Federica Sallusto, Ferry Ossendorp, G Sutter, Giuseppe Pantaleo, GK Smith, J Tartaglia, J Tartaglia, JA Espmark, JA Symons, Jean-Philippe Goulet, Jim Tartaglia, JL Najera, JL Najera, Karen V. Kibler, L Jing, L Jing, LJ Sigal, M Carrington, M Esteban, M Terajima, Mariano Esteban, ME Perkus, ME Perkus, MJ Kuroda, MP Longhi, N Frahm, N Frahm, N Oguiura, N Romani, N van Montfoort, NA Wilson, Nikki M. Loof, OR Colamonici, P Mooij, P Mooij, PA Bart, Paul Heinen, RA Koup, Rafick P. Sékaly, RN Van Gelder, RP Sekaly, S Guerra, S McCormack, S Rerks-Ngarm, SA Migueles, SS Jackson, Stella Mayo McCaughey, Thomas Duhen, X Shen, X Wei, Y Benjamini, Z Hel, Z Hel   +84 more
core   +4 more sources