Results 131 to 140 of about 153,995 (247)

Mucosal tenofovir 1% gel stimulates cell proliferation and type I/III interferon pathways

Microbiology Spectrum
Oral tenofovir is a key antiretroviral used for treatment and pre-exposure prophylaxis (PrEP) of human immunodeficiency virus (HIV). A gel form has been tested for vaginal and rectal PrEP.
Sean M. Hughes, Fernanda L. Calienes, Claire N. Levy, Urvashi Pandey, Germán G. Gornalusse, Ross D. Cranston, Javier R. Lama, Jim Pickett, Rhonda M. Brand, Craig W. Hendrix, Mark A. Marzinke, James Y. Dai, Bhavna Balar, Jessica E. Justman, Gonasagrie Nair, Alicia R. Berard, Kenzie Birse, Laura Noel-Romas, Kenneth H. Mayer, Joanne D. Stekler, Romel Mackelprang, Adam D. Burgener, Ian McGowan, Cheryl M. Cameron, Mark J. Cameron, Kim A. Woodrow, Florian Hladik   +26 more
doaj   +1 more source

Reducing off-target drug accumulation by exploiting a type-III interferon response. [PDF]

J Control Release, 2023
Tilden SG, Ricco MH, Hemann EA, Anchordoquy TJ.   +3 more
europepmc   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Biological Activity of Optimized Codon Bovine Type III Interferon Expressed in Pichia pastoris. [PDF]

Viruses, 2023
An R, Zhang R, Guo Y, Geng J, Si M, Wang S, Gao M, Wang J.   +7 more
europepmc   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells

, 2011
Includes abstract.Includes bibliographical references (leaves 110-135).Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion.
Rose, Beverley Ann
core  

SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas. [PDF]

Cell Host Microbe, 2023
Wickramage I, VanWye J, Max K, Lockhart JH, Hortu I, Mong EF, Canfield J, Lamabadu Warnakulasuriya Patabendige HM, Guzeloglu-Kayisli O, Inoue K, Ogura A, Lockwood CJ, Akat KM, Tuschl T, Kayisli UA, Totary-Jain H.   +15 more
europepmc   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Type III interferon drives thymic B cell activation and regulatory T cell generation. [PDF]

Proc Natl Acad Sci U S A, 2023
Martinez RJ, Breed ER, Worota Y, Ashby KM, Vobořil M, Mathes T, Salgado OC, O'Connor CH, Kotenko SV, Hogquist KA.   +9 more
europepmc   +1 more source