Results 181 to 190 of about 10,540,033 (277)

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

miR-615 facilitates porcine epidemic diarrhea virus replication by targeting IRAK1 to inhibit type III interferon expression. [PDF]

Front Microbiol, 2022
Zheng HQ, Li C, Zhu XF, Wang WX, Yin BY, Zhang WJ, Feng SL, Yin XH, Huang H, Zhang YM.   +9 more
europepmc   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells. [PDF]

J Virol, 2022
Metz-Zumaran C, Kee C, Doldan P, Guo C, Stanifer ML, Boulant S.   +5 more
europepmc   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Role of type I and type III interferons: A review of concepts

, 2019
Los interferones (IFN), inicialmente denominados como “mediadores solubles que interfieren con la infección celular por el virus de la gripe A”, son familias de proteínas secretadas que regulan la inmunidad innata y adquirida tras la activación de receptores de reconocimiento de patrones (PRR). Los IFN tienen un impacto en los procesos de proliferación,
Marín Sánchez, Obert, Vivas-Ruiz, Dan, Neira, Miguel, Sandoval, Gustavo A., Marín- Machuca, Olegario, Rodriguez-Landauro, Ana Juliet, Chacón, Ruy D.   +6 more
openaire   +1 more source

African swine fever virus pM448R protein promotes STUB1-mediated ubiquitin-proteasome degradation of IRF1 to attenuate type III interferon induction. [PDF]

J Virol
Zhao J, Xie J, Shi Y, Mou C, Chen Z.
europepmc   +1 more source

Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection. [PDF]

Virol Sin, 2023
Mo Q, Feng K, Dai S, Wu Q, Zhang Z, Ali A, Deng F, Wang H, Ning YJ.   +8 more
europepmc   +1 more source