Results 221 to 230 of about 147,258 (248)

Type III interferon enhances thymic B cell licensing

The Journal of Immunology, 2022
Abstract The activation of thymic B cells is critical for their licensing as antigen presenting cells and resulting ability to mediate central immune tolerance. The processes leading to thymic B cell licensing are still not fully understood.
Ryan J Martinez, Elise Breed, Yosan Worota, Katherine Ashby, Lily Qian, Kristin Ann Hogquist   +5 more
openaire   +1 more source

Type-III interferons in Sjögren's syndrome.

Clinical and experimental rheumatology, 2020
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterised by aberrant activation of innate and adaptive immune responses. Part of this hyper-activation is due to the interferon (IFN) system. Deregulated expression and activity of the type-I IFN system has been extensively studied in pSS.
Eirini, Apostolou, Athanasios G, Tzioufas   +1 more
openaire   +1 more source

Structure–function of type I and III interferons

Current Opinion in Immunology
Type I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross ...
Nicole A, de Weerd, Aleksandra K, Kurowska, Juan L, Mendoza, Gideon, Schreiber   +3 more
openaire   +2 more sources

Type III interferon networks in systemic lupus erythematosus

The Journal of Immunology, 2020
Abstract Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of nucleic acid autoantibodies and immune complex deposition resulting in organ damage. A type I interferon (IFN) gene signature historically attributed to IFN-α is found in cells from SLE ...
Jennifer L Barnas, Jennifer Albrecht, Nida Meednu, Neha D Nandedkar-Kulkarni, Mary O’Connell, R John Looney, Jennifer H Anolik   +6 more
openaire   +1 more source

Type III interferons (IFNs): Emerging Master Regulators of Immunity

2015
Lambda interferons (IFN-λs), type III interferons or interleukins 28 and 29 are the latest addition to the class II cytokine family. They share low homology with the interferon (IFN) and IL-10 cytokine families, yet they exhibit common and unique activities, the full spectrum of which still remains incompletely understood.
Ioanna E, Galani, Ourania, Koltsida, Evangelos, Andreakos   +2 more
openaire   +2 more sources

Antiviral activity of type I interferons and interleukins 29 and 28a (type III interferons) against Apeu virus

Antiviral Research, 2008
Interferons (IFNs) are cytokines with important immunomodulatory activity in vertebrates. Although type I IFNs and interleukins (IL) 29 and 28a (type III IFNs) bind to different cellular receptors and have distinct structures, most of their biological activities are redundant.
Gabriel Magno de Freitas, Almeida, Danilo Bretas, de Oliveira, Cintia Lopes de Brito, Magalhães, Cláudio Antônio, Bonjardim, Paulo César Peregrino, Ferreira, Erna Geessien, Kroon   +5 more
openaire   +2 more sources

Type III Interferon Protects Swine Against Foot-and-Mouth Disease

Journal of Interferon & Cytokine Research, 2014
In recent years, we have developed novel strategies to control foot-and-mouth disease (FMD), including the use of biotherapeutics such as interferons (IFN) delivered by a replication-defective human adenovirus type 5 (Ad5). Swine can be sterilely protected after vaccination with an Ad5 that encodes porcine type I IFN (poIFN-α), and cattle can be ...
Eva, Perez-Martin, Fayna, Diaz-San Segundo, Marcelo, Weiss, Diego F, Sturza, Camila C, Dias, Elizabeth, Ramirez-Medina, Marvin J, Grubman, Teresa, de los Santos   +7 more
openaire   +2 more sources

Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation

Immunity, 2022
Kelly M Cautivo, Nicholas Mroz, Xiaofei Yu   +2 more
exaly  

Type III interferon (IFN-lambda) antagonizes the antiviral activity of interferon-alpha in vitro.

Journal of biological regulators and homeostatic agents, 2014
Type III interferons (IFN-lambda) are the most recently discovered members of IFN family. Synergism between different IFN types is well established, but for type I and type III IFNs no conclusive evidence has been reported so far. Possible synergism/antagonism between IFN-alpha and IFN-lambda in the inhibition of virus replication (EMCV, WNV lineage 1 ...
Capobianchi, M. R., Lapa, D., Quartu, S., Castilletti, C., Caglioti, C., Lalle, E., Bordi, L.   +6 more
openaire   +1 more source

Type III interferon activity in the brain

Cytokine, 2009
Prasanthi Bandi, Nyree Maes, Minjung Han, Anthony den Pol, Michael D. Robek   +4 more
openaire   +1 more source