Results 261 to 270 of about 10,540,033 (277)

Mechanisms of Type III Interferon Expression

Journal of Interferon & Cytokine Research, 2010
Type III interferons (IFNs; IFN-lambda) are antiviral cytokines with type I IFN-like biological functions, including antiviral activity. In this article we review the literature on IFN-lambda expression and propose that important differences exist between the mechanisms governing expression of the different classes of IFNs.
Iversen, Marie Beck, Paludan, Søren R
openaire   +3 more sources

Structure–function of type I and III interferons

Current Opinion in Immunology
Type I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross ...
Nicole A, de Weerd, Aleksandra K, Kurowska, Juan L, Mendoza, Gideon, Schreiber   +3 more
openaire   +2 more sources

Type-III interferons in Sjögren's syndrome.

Clinical and experimental rheumatology, 2020
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterised by aberrant activation of innate and adaptive immune responses. Part of this hyper-activation is due to the interferon (IFN) system. Deregulated expression and activity of the type-I IFN system has been extensively studied in pSS.
Eirini, Apostolou, Athanasios G, Tzioufas   +1 more
openaire   +1 more source

Type III interferons prime neutrophils

Science, 2017
Fungal Infection Type I interferons (IFNs) have a well-established role in antiviral immunity. Espinosa et al. found that type III IFNs (IFN-λs) play an essential role in driving antifungal responses. They studied immune responses to Aspergillus fumigatus in mice lacking receptors for type I or type III IFNs.
openaire   +1 more source

Type I and III Interferon Production in Response to RNA Viruses

Journal of Interferon & Cytokine Research, 2014
The biology of RNA viruses is closely linked to the type I and type III interferon (IFN) response of the host. These viruses display a range of molecular patterns that may be detected by host cells resulting in the induction of IFNs. Consequently, there are many examples of mechanisms employed by RNA viruses to block or delay IFN induction and reduce ...
Elizabeth, Reid, Bryan, Charleston
openaire   +2 more sources

Role of type-I and type-III interferons in gastrointestinal homeostasis and pathogenesis

Current Opinion in Immunology
Interferon (IFN) was discovered based on interference with virus production, and three types of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to diverse pathogen types, tissue homeostasis, and inflammatory disease. The gastrointestinal (GI) tract is arguably the tissue where the roles of IFN types are most distinct,
Austin P, Wright, Timothy J, Nice
openaire   +2 more sources

Type III interferons (IFNs): Emerging Master Regulators of Immunity

2015
Lambda interferons (IFN-λs), type III interferons or interleukins 28 and 29 are the latest addition to the class II cytokine family. They share low homology with the interferon (IFN) and IL-10 cytokine families, yet they exhibit common and unique activities, the full spectrum of which still remains incompletely understood.
Ioanna E, Galani, Ourania, Koltsida, Evangelos, Andreakos   +2 more
openaire   +2 more sources

Type III interferons in innate and adaptive immunity in the respiratory tract

Current Opinion in Immunology
Lambda interferons (IFNλs), also termed type III interferons (IFNs) or interleukins-28/29, have been in the shadow of type I IFNs for a long time. Their common induction mechanisms and signalling cascades with type I IFNs have made difficult the unwinding of their unique nonredundant functions.
Artemios Piperakis, Ioanna E Galani, Evangelos Andreakos   +2 more
openaire   +2 more sources

Type III interferon (IFN-lambda) antagonizes the antiviral activity of interferon-alpha in vitro.

Journal of biological regulators and homeostatic agents, 2014
Type III interferons (IFN-lambda) are the most recently discovered members of IFN family. Synergism between different IFN types is well established, but for type I and type III IFNs no conclusive evidence has been reported so far. Possible synergism/antagonism between IFN-alpha and IFN-lambda in the inhibition of virus replication (EMCV, WNV lineage 1 ...
Capobianchi, M. R., Lapa, D., Quartu, S., Castilletti, C., Caglioti, C., Lalle, E., Bordi, L.   +6 more
openaire   +1 more source

Type III interferon activity in the brain

Cytokine, 2009
Prasanthi Bandi, Nyree Maes, Minjung Han, Anthony den Pol, Michael D. Robek   +4 more
openaire   +1 more source