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Type III Secretion Systems and Disease [PDF]
Clinical Microbiology Reviews, 2007 SUMMARY Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-negative pathogens with a unique virulence mechanism enabling them to inject bacterial effector proteins directly into the host cell cytoplasm, bypassing the extracellular milieu.
Bryan, Coburn +2 more
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Bordetella Type III Secretion Injectosome and Effector Proteins
Frontiers in Cellular and Infection Microbiology, 2020 Pertussis, also known as whooping cough, is a resurging acute respiratory disease of humans primarily caused by the Gram-negative coccobacilli Bordetella pertussis, and less commonly by the human-adapted lineage of B. parapertussisHU.
Jana Kamanova
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Fueling type III secretion [PDF]
Trends in Microbiology, 2015 Type III secretion systems (T3SSs) are complex nanomachines that export proteins from the bacterial cytoplasm across the cell envelope in a single step. They are at the core of the machinery used to assemble the bacterial flagellum, and the needle complex many Gram-negative pathogens use to inject effector proteins into host cells and cause disease ...
Pei-Chung, Lee, Arne, Rietsch
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Type III secretion system [PDF]
Current Biology, 2014 The type III secretion system (T3SS) is a membrane-embedded nanomachine found in several Gram-negative bacteria. Upon contact between bacteria and host cells, the syringe-like T3SS (Figure 1) transfers proteins termed effectors from the bacterial cytosol to the cytoplasm or the plasma membrane of a single target cell.
Puhar, Andrea, Sansonetti, Philippe J.
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Nature Communications, 2022 Agrobacterium-mediated plant transformation (AMT) is the basis of modern-day plant biotechnology. One major drawback of this technology is the recalcitrance of many plant species/varieties to Agrobacterium infection, most likely caused by elicitation of ...
V. Raman +11 more
semanticscholar +1 more source
Differential regulation of Shigella Spa47 ATPase activity by a native C-terminal product of Spa33
Frontiers in Cellular and Infection Microbiology, 2023 Shigella is a Gram-negative bacterial pathogen that relies on a single type three secretion system (T3SS) as its primary virulence factor. The T3SS includes a highly conserved needle-like apparatus that directly injects bacterial effector proteins into ...
Heather B. Case +3 more
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Type III secretion: The bacteria-eukaryotic cell express [PDF]
FEMS Microbiology Letters, 2005 Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell ...
Mota, L. J., Sorg, I., Cornelis, G. R.
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Effective identification of bacterial type III secretion signals using joint element features. [PDF]
PLoS ONE, 2013 Type III secretion system (T3SS) plays important roles in bacteria and host cell interactions by specifically translocating type III effectors into the cytoplasm of the host cells.
Yejun Wang +4 more
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The type III secretion system effector network hypothesis.
Trends in Microbiology, 2021 Type III secretion system (T3SS) effectors are key virulence factors that underpin the infection strategy of many clinically important Gram-negative pathogens, including Salmonella enterica, Shigella spp., enteropathogenic and enterohemorrhagic ...
Julia Sanchez-Garrido +3 more
semanticscholar +1 more source
Translation/Secretion Coupling by Type III Secretion Systems [PDF]
Cell, 2000 Type III secretion systems mediate export of virulence proteins and flagellar assembly subunits in Gram-negative bacteria. Chaperones specific to each class of secreted protein are believed to prevent degradation of the secreted substrates. We show that an additional role of chaperones may be to regulate translation of secreted proteins.
Karlinsey, Joyce E +3 more
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