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The Shigella Type III Secretion System: An Overview from Top to Bottom
Microorganisms, 2021 Shigella comprises four species of human-restricted pathogens causing bacillary dysentery. While Shigella possesses multiple genetic loci contributing to virulence, a type III secretion system (T3SS) is its primary virulence factor.
M. Muthuramalingam +3 more
semanticscholar +1 more source
The Missing Pieces: The Role of Secretion Systems in Campylobacter jejuni Virulence
Biomolecules, 2023 Campylobacter jejuni is likely the most common bacterial cause of gastroenteritis worldwide, responsible for millions of cases of inflammatory diarrhea characterized by severe abdominal cramps and blood in the stool. Further, C.
Amber D. Gabbert +7 more
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Engineering Agrobacterium tumefaciens with a Type III Secretion System to Express Type III Effectors
Bio-Protocol, 2023 Plants elicit defense responses when exposed to pathogens, which partly contribute to the resistance of plants to Agrobacterium tumefaciens–mediated transformation.
Vidhyavathi Raman, Kirankumar Mysore
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Type III secretion system effector proteins are mechanically labile
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The type III secretion system (T3SS) is an important virulence factor that enables some bacteria to directly inject effector proteins into host cells, facilitating colonization. To be secreted, effector proteins must be unfolded, and tightly
M. LeBlanc +3 more
semanticscholar +1 more source
Protein Export via the Type III Secretion System of the Bacterial Flagellum
Biomolecules, 2021 The bacterial flagellum and the related virulence-associated injectisome system of pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins across the inner membrane in a proton motive force-dependent manner.
Manuel Halte, M. Erhardt
semanticscholar +1 more source
Molecular Plant-Microbe Interactions, 2005 avrXa7 is a member of the avrBs3/pthA gene family. The gene is a critical type III effector in several strains of Xanthomonas oryzae pv. oryzae (virulence activity), and in the presence of the Xa7 host gene for resistance, controls the elicitation of ...
Bing Yang, Akiko Sugio, Frank F. White
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Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems [PDF]
, 2003 Type III secretion systems enable plant and animal bacterial pathogens to deliver virulence proteins into the cytosol of eukaryotic host cells, causing a broad spectrum of diseases including bacteremia, septicemia, typhoid fever, and bubonic plague in ...
A. P. Tampakaki +33 more
core +2 more sources
Type III secretion à la Chlamydia [PDF]
Trends in Microbiology, 2007 Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-dependent, T3S-mediated chlamydial ...
Peters, Jan M +4 more
openaire +3 more sources
Molecular Plant-Microbe Interactions, 1998 The host range of the gall-forming bacterium Erwinia herbicola pv. gypsophilae (Ehg) is restricted to the gypsophila plant whereas E. herbicola pv. betae (Ehb) incites galls on beet as well as gypsophila.
Lea Valinsky +4 more
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ATPase-independent type-III protein secretion in Salmonella enterica. [PDF]
PLoS Genetics, 2014 Type-III protein secretion systems are utilized by gram-negative pathogens to secrete building blocks of the bacterial flagellum, virulence effectors from the cytoplasm into host cells, and structural subunits of the needle complex.
Marc Erhardt +3 more
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