Results 61 to 70 of about 1,118,779 (342)

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Eggplant and related species are promising genetic resources to dissect the plant immune response to Pseudomonas syringae and Xanthomonas euvesicatoria and to identify new resistance determinants [PDF]

, 2014
The apparent lack of durability of many resistance (R) genes highlights the need for the constant identification of new genetic sources of resistance for the breeding of new disease-resistant crop cultivars.
Clarke, Christopher R., Hayes, Byron W., Runde, Brendan J., Vinatzer, Boris A., Wicker, Emmanuel   +4 more
core   +1 more source

Bacterial type III secretion systems: a complex device for the delivery of bacterial effector proteins into eukaryotic host cells

FEMS Microbiology Letters, 2018
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells. They are able to secrete a great diversity of substrate proteins in order to modulate host cell function, and have ...
Samuel Wagner, I. Grin, Silke Malmsheimer, Nidhi Singh, C. Torres-Vargas, Sibel Westerhausen   +5 more
semanticscholar   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Identification of chromosomal genes in Yersinia pestis that influence type III secretion and delivery of Yops into target cells. [PDF]

PLoS ONE, 2012
Pathogenic Yersinia species possess a type III secretion system, which is required for the delivery of effector Yop proteins into target cells during infection.
Andrew S Houppert, Elizabeth Kwiatkowski, Elizabeth M Glass, Kristin L DeBord, Peter M Merritt, Olaf Schneewind, Melanie M Marketon   +6 more
doaj   +1 more source

Presence of genes for type III secretion system 2 in strains [PDF]

, 2010
Background Vibrios, which include more than 100 species, are ubiquitous in marine and estuarine environments, and several of them e.g. Vibrio cholerae, V. parahaemolyticus, V. vulnificus and V. mimicus, are pathogens for humans.
Natsumi Okada, Shigeaki Matsuda, Junko Matsuyama, Kwon-Sam Park, Calvin de los Reyes, Kazuhiro Kogure, Takeshi Honda, Tetsuya Iida, CJ Hueck, KG Jarvis, RD Perry, JJ Farmer III, FL Thompson, E Rosenberg, K Makino, PA Blake, T Honda, M Nishibuchi, R Sakazaki, T Iida, M Nishibuchi, KS Park, K Izutsu, S Chatterjee, M Dziejman, JM Henke, RA Murphy, N Okada, T Iida, T Kodama, T Kodama, AD Livermans, GJ Vora, T Li   +33 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Small-Molecule Inhibitors of the Type III Secretion System

Molecules, 2015
Drug-resistant pathogens have presented increasing challenges to the discovery and development of new antibacterial agents. The type III secretion system (T3SS), existing in bacterial chromosomes or plasmids, is one of the most complicated protein ...
Lingling Gu, Shanshan Zhou, Lanping Zhu, Cuirong Liang, Xin Chen   +4 more
doaj   +1 more source

The Architecture of the Cytoplasmic Region of Type III Secretion Systems [PDF]

, 2016
Type III secretion systems (T3SSs) are essential devices in the virulence of many Gram-negative bacterial pathogens. They mediate injection of protein effectors of virulence from bacteria into eukaryotic host cells to manipulate them during infection ...
Blocker, Ariel J, Kajimura, Naoko, Kawamoto, Akihiro, Makino, Fumiaki, Murillo Cabeza, Isabel, Namba, Keiichi, Oswin, Henry, Pain, Maria, Pissaridou, Panayiota, Shen, Dakang   +9 more
core   +3 more sources