Results 71 to 80 of about 1,118,779 (342)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
BopN is a Gatekeeper of the Bordetella Type III Secretion System
Microbiology Spectrum, 2023 The classical Bordetella species infect the respiratory tract of mammals. While B. bronchiseptica causes rather chronic respiratory infections in a variety of mammals, the human-adapted species B. pertussis and B.
Kevin Munoz Navarrete +6 more
doaj +1 more source
bioRxiv, 2018 Many important gram-negative bacterial pathogens use highly sophisticated type III secretion systems (T3SSs) to establish complex host-pathogen interactions.
Donghyun R Park +7 more
semanticscholar +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Animal Models of Type III Secretion System-Mediated Pathogenesis
Pathogens, 2019 The type III secretion system (T3SS) is a conserved virulence factor used by many Gram-negative pathogenic bacteria and has become an important target for anti-virulence drugs.
Julia A. Hotinger, Aaron E. May
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Chlamydia trachomatis is an obligate intracellular pathogen that actively promotes invasion of epithelial cells. A virulence-associated type III secretion system contributes to chlamydial entry and at least four effectors have been described that are ...
Kaylyn R. Scanlon +4 more
doaj +1 more source
Proteins adopt functionally active conformations after type III secretion [PDF]
, 2016 Additional file 1.
Danielle Tullman-Ercek +5 more
core +2 more sources
Bacterial flagella and type III secretion systems [PDF]
FEMS Microbiology Letters, 2001 Certain classes of pathogenic bacteria secrete virulence proteins in a Sec-independent manner, by a mechanism known as type III secretion. The main body of the export apparatus specific for virulence proteins is identified as a needle complex, which has a similar structural organization to flagella. The two structures share several proteins with highly
openaire +2 more sources
Factors triggering type III secretion in Pseudomonas aeruginosa [PDF]
Microbiology, 2005 The type III secretion system ofPseudomonas aeruginosais tightly regulated by various environmental signals, such as low calcium and contact with the host cell. However, the exact signals triggering type III secretion are unknown. The present study describes the finding that secretion ofP.
Jaewha, Kim +6 more
openaire +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source