Results 91 to 100 of about 259,068 (324)

Delivery of an Rhs‐family nuclease effector reveals direct penetration of the gram‐positive cell envelope by a type VI secretion system in Acidovorax citrulli

mLife, 2022
The type VI secretion system (T6SS) is a double‐tubular nanomachine widely found in gram‐negative bacteria. Its spear‐like Hcp tube is capable of penetrating a neighboring cell for cytosol‐to‐cytosol protein delivery. However, gram‐positive bacteria have
Tong-Tong Pei, Yumin Kan, Zenghang Wang, Ming-Xuan Tang, Hao Li, Shuangquan Yan, Yang Cui, Hao-Yu Zheng, Han Luo, Xiaoye Liang, Tao G. Dong   +10 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Architecture and assembly of the Type VI secretion system

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014
The Type VI secretion system (T6SS) delivers protein effectors to diverse cell types including prokaryotic and eukaryotic cells, therefore it participates in inter-bacterial competition and pathogenesis. The T6SS is constituted of an envelope-spanning complex anchoring a cytoplasmic tubular edifice.
Zoued, Abdelrahim, Brunet, Yannick R, Durand, Eric, Aschtgen, Marie-Stéphanie, Logger, Laureen, Douzi, Badreddine, Journet, Laure, Cambillau, Christian, Cascales, E.   +8 more
openaire   +4 more sources

Regulation of Type VI Secretion System during Burkholderia pseudomallei Infection [PDF]

Infection and Immunity, 2011
ABSTRACT Type III and type VI secretion systems (T3SSs and T6SSs, respectively) are critical virulence determinants in several Gram-negative pathogens. In Burkholderia pseudomallei , the T3SS-3 and T6SS-1 clusters have been implicated in bacterial virulence in mammalian hosts.
Yahua, Chen, Jocelyn, Wong, Guang Wen, Sun, Yichun, Liu, Gek-Yen Gladys, Tan, Yunn-Hwen, Gan   +5 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Assembly and Subcellular Localization of Bacterial Type VI Secretion Systems [PDF]

Annual Review of Microbiology, 2019
Bacteria need to deliver large molecules out of the cytosol to the extracellular space or even across membranes of neighboring cells to influence their environment, prevent predation, defeat competitors, or communicate. A variety of protein-secretion systems have evolved to make this process highly regulated and efficient. The type VI secretion system (
Wang, Jing, Brodmann, Maj, Basler, Marek
openaire   +4 more sources

Functional regulation and cross-talk of type III and Type VI secretion systems in Salmonella

Virulence
In Salmonella, the type III and type VI secretion systems (T3SS and T6SS) play critical roles in pathogenicity. The bacterium harbors two distinct T3SSs: T3SS-1, encoded by SPI-1, promotes host cell invasion, whereas T3SS-2 (located within SPI-2 ...
Xingyi Li, Ying Ding, Yu Sun, Yiting Gu, Wanli Feng, Yanyan Jia, Huimin Chen, Songbiao Chen   +7 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Role of Klebsiella pneumoniae Type VI secretion system (T6SS) in long-term gastrointestinal colonization

Scientific Reports, 2022
Type VI secretion systems (T6SS), recently described in hypervirulent K. pneumoniae (hvKp) strains, are involved in bacterial warfare but their role in classical clinical strains (cKp) has been little investigated.
Thomas Merciecca, S. Bornes, Laurence Nakusi, S. Theil, Olaya Rendueles, C. Forestier, S. Miquel   +6 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source