Results 71 to 80 of about 25,500,999 (291)

Assessing toxicity and competitive fitness of Vibrio isolates from coastal waters in Israel

mSphere
Several species of aquatic bacteria belonging to the genus Vibrio are emerging pathogens of humans and marine animals. Vibrio-associated infections have been shown to correlate with the increase in the oceans’ surface water temperatures.
Katarzyna Kanarek, Kinga Keppel, Hadar Cohen, Chaya Mushka Fridman, Motti Gerlic, Dor Salomon   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Biological and Regulatory Role of Type VI Secretion System of Klebsiella pneumoniae

, 2023
Wenke Liu,1,* Min Li,1,* Shiwen Cao,1 Hafiz Muhammad Ishaq,2 Huajie Zhao,1 Fan Yang,1 Liang Liu1 1Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Faculty of ...
Ishaq HM, Liu L, Cao S, Li M, Yang F, Liu W, Zhao H   +6 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Interactions between pili affect the outcome of bacterial competition driven by the type VI secretion system [PDF]

The bacterial type VI secretion system (T6SS) is a widespread, kin-discriminatory weapon capable of shaping microbial communities. Due to the system’s dependency on contact, cellular interactions can lead to either competition or kin protection.
Blokesch, Melanie, Lemopoulos, Alexandre, Servajean, Richard Marie, Bitbol, Anne-Florence, Otto, Simon Bernhard   +4 more
core   +3 more sources

Functional regulation and cross-talk of type III and type VI secretion systems in Salmonella

Virulence
In Salmonella, the type III and type VI secretion systems (T3SS and T6SS) play critical roles in pathogenicity. The bacterium harbors two distinct T3SSs: T3SS-1, encoded by SPI-1, promotes host cell invasion, whereas T3SS-2 (located within SPI-2 ...
Xingyi Li, Ying Ding, Yu Sun, Yiting Gu, Wanli Feng, Yanyan Jia, Huimin Chen, Songbiao Chen   +7 more
doaj   +1 more source

Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria.

PLoS Pathogens, 2015
The type VI secretion system (T6SS) is a widespread protein secretion apparatus used by Gram-negative bacteria to deliver toxic effector proteins into adjacent bacterial or host cells.
Dor Salomon, John A Klimko, David C Trudgian, Lisa N Kinch, Nick V Grishin, Hamid Mirzaei, Kim Orth   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Collective protection against the type VI secretion system in bacteria

The ISME Journal, 2022
Abstract Bacteria commonly face attacks from other strains using the type VI secretion system (T6SS), which acts like a molecular speargun to stab and intoxicate competitors. Here we show how bacteria can work together to collectively defend themselves against these attacks.
Elisa T. Granato, William P. J. Smith, Kevin R. Foster   +2 more
openaire   +4 more sources

Microreview: type IV secretion systems: versatility and diversity in function [PDF]

, 2010
Type IV secretion systems (T4SSs) are large protein complexes which traverse the cell envelope of many bacteria. They contain a channel through which proteins or protein–DNA complexes can be translocated.
Angel Rivera-Calzada, Walldén, Karin, Waksman, Gabriel, Rivera-Calzada, A., Karin Wallden, Gabriel Waksman   +5 more
core   +1 more source