Results 91 to 100 of about 24,060,770 (296)

The Biological and Regulatory Role of Type VI Secretion System of Klebsiella pneumoniae

, 2023
Wenke Liu,1,* Min Li,1,* Shiwen Cao,1 Hafiz Muhammad Ishaq,2 Huajie Zhao,1 Fan Yang,1 Liang Liu1 1Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Faculty of ...
Ishaq HM, Liu L, Cao S, Li M, Yang F, Liu W, Zhao H   +6 more
core  

Helicobacter pylori type IV secretion apparatus exploits beta1 integrin in a novel RGD-independent manner. [PDF]

, 2009
Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for severe gastric diseases, including gastric cancer.
Haas, Rainer, Rainer Haas, Kapp, Ulrike, Jung, Kirsten, Kirsten Jung, Rohde, Manfred, Claudia Ertl, Retta, S. Francesco, S. Francesco Retta, Terradot Laurent, Ertl, Claudia, Luisa F. Jiménez-soto, Luisa F Jiménez-Soto, Fischer Rainer Haas, Retta S. Francesco, Pirch Torsten, Weiss, Evelyn, Xaver Sewald, Jiménez-Soto Luisa F., Wolfgang Fischer, Ertl Claudia, Evelyn Weiss, Jiménez-Soto, Luisa F., Fischer, Wolfgang, Weiss Evelyn, Manfred Rohde, Kutter, Stefan, Kutter Stefan, Pirch, Torsten, Terradot, Laurent, Sewald, Xaver, Fischer Wolfgang, Torsten Pirch, Laurent Terradot, S Francesco Retta, Haas Rainer, Rohde Manfred, Kapp Ulrike, Ulrike Kapp, Retta, Saverio Francesco, Stefan Kutter, Jung Kirsten, Sewald Xaver   +42 more
core   +2 more sources

A New Front in Microbial Warfare—Delivery of Antifungal Effectors by the Type VI Secretion System

Journal of Fungi, 2019
Microbes typically exist in mixed communities and display complex synergistic and antagonistic interactions. The Type VI secretion system (T6SS) is widespread in Gram-negative bacteria and represents a contractile nano-machine that can fire effector ...
Katharina Trunk, Sarah J. Coulthurst, Janet Quinn   +2 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Type VI secretion system sheaths as nanoparticles for antigen display [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Critical aspects that limit use of nanoparticles as vaccine delivery systems include the technical difficulty of preparing particles under conditions that allow controlled protein loading and folding. Biologic nanoparticles offer advantages over chemically derived particles that require harsh organic solvents for ...
Elena, Del Tordello, Olga, Danilchanka, Andrew J, McCluskey, John J, Mekalanos   +3 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Vibrio cholerae Type VI Secretion System: Evaluating Its Role in the Human Disease Cholera

Frontiers in Cellular and Infection Microbiology, 2010
Vibrio cholerae, the marine bacterium responsible for the diarrheal disease cholera, utilizes a multitude of virulence factors to cause disease. The importance of two of these factors, the toxin co-regulated pilus (TCP) and cholera toxin (CT), has been ...
Sarah T. Miyata, Maya eKitaoka, Lukasz eWieteska, Christian eFrech, Nansheng eChen, Stefan ePukatzki   +5 more
doaj   +1 more source

Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system

Nature Communications, 2020
Bacterial Rhs proteins with toxic domains are often secreted by type VI secretion systems. Here, the authors show that one of these proteins self-cleaves into three fragments, with the Rhs core and the N-terminal domain facilitating secretion and ...
Tong-Tong Pei, Hao Li, Xiaoye Liang, Zeng-Hang Wang, Guangfeng Liu, Li-Li Wu, Haeun Kim, Zhiping Xie, Ming Yu, Shuangjun Lin, Ping Xu, Tao G. Dong   +11 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Trw Type IV Secretion System of Bartonella Mediates Host-Specific Adhesion to Erythrocytes [PDF]

, 2010
Bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood.
Danchin, Antoine, Philipp Engel, Dehio, Christoph, Quebatte, Maxime, Le Rhun, Danielle, Vayssier-Taussat Muriel, Maxime Quebatte, Saenz, Henri, Lionel Arnaud, Mavris, Arnaud Lionel, Lenaour Evelyne, Yang, Huanming, Sandra Cescau, Wang Jing, Mavris, Maria, Lenaour, Evelyne, Boulouis, Henri Jean, Taussat, Muriel, Antoine Danchin, Vayssier-Taussat, Muriel, Deng Hong Kuan, Jing Wang, Huanming Yang, Boulouis Henri Jean, Arnaud, Lionel, Quebatte Maxime, Engel, Philipp, Le Naour, Evelyne, Muriel Vayssier-Taussat, Henri Saenz, Maria Mavris, Dehio Christoph, Biville Francis, Danielle Le Rhun, Le Rhun Danielle, Danchin Antoine, Francis Biville, Christoph Dehio, Biville, Francis, Geneviève Marignac, Yang Huanming, Engel Philipp, Hong Kuan Deng, Cescau Sandra, Evelyne Lenaour, Mavris Maria, Deng, H.K., Deng, Hong Kuan, Wang, Jing, Marignac Geneviève, Cescau, Sandra, Marignac, Geneviève, Boulouis, Henri-Jean, Henri Jean Boulouis, Arnaud Lionel, Saenz Henri   +55 more
core   +1 more source