Results 121 to 130 of about 25,500,999 (291)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Visual comparison of the TEC Type VI Secretion System.

, 2015
tBLASTx comparison of the Type VI Secretion System (T6SS) genomic island and flanking regions in E. coli HLMN-1, E. coli PC-1, E. coli KIC-1, E. coli KIC-2, E. coli 46–4 and E. coli 73–89.
Nathan L. Bachmann (789941), Mohammad Katouli (789942), Adam Polkinghorne (81145)   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Genome-wide Investigation of Vibrio parahaemolyticus Type III Secretion System-1 Regulation and Chitin Metabolism

, 2022
Vibrio parahaemolyticus is the leading cause of seafood-borne gastroenteritis in humans following the consumption of contaminated seafood, and is a consequential organism for aquaculture and human health.
Getz, Landon John
core  

Characterization of the SPI-1 and Rsp type three secretion systems in Pseudomonas fluorescens F113 [PDF]

, 2013
Pseudomonas fluorescens F113 is a plant growthpromoting rhizobacterium (PGPR) isolated from the sugar beet rhizosphere. The recent annotation of the F113 genome sequence has revealed that this strain encodes a wide array of secretion systems, including ...
Matthieu Barret, Moynihan, Jennifer, Lesouhaitier, Olivier, Morrissey, John, Egan, Frank, Olivier Lesouhaitier, Morrissey, John P., Frank Egan, John P. Morrissey, Fergal O'Gara, Barret, Matthieu, Jennifer Moynihan, O'Gara, Fergal   +12 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

The Vibrio type VI secretion system induces intestinal macrophage redistribution and enhanced intestinal motility

mBio
Intestinal microbes, whether resident or transient, influence the physiology of their hosts, altering both the chemical and the physical characteristics of the gut. An example of the latter is the human pathogen Vibrio cholerae’s ability to induce strong
Julia S. Ngo, Piyush Amitabh, Jonah G. Sokoloff, Calvin Trinh, Travis J. Wiles, Karen Guillemin, Raghuveer Parthasarathy   +6 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition

MicrobiologyOpen, 2019
Burkholderia cenocepacia is an opportunistic bacterial pathogen that poses a significant threat to individuals with cystic fibrosis by provoking a strong inflammatory response within the lung.
Helena L. Spiewak, Sravanthi Shastri, Lili Zhang, Stephan Schwager, Leo Eberl, Annette C. Vergunst, Mark S. Thomas   +6 more
doaj   +1 more source

Fha interaction with phosphothreonine of TssL activates type VI secretion in Agrobacterium tumefaciens.

PLoS Pathogens, 2014
The type VI secretion system (T6SS) is a widespread protein secretion system found in many Gram-negative bacteria. T6SSs are highly regulated by various regulatory systems at multiple levels, including post-translational regulation via threonine (Thr ...
Jer-Sheng Lin, Hsin-Hui Wu, Pang-Hung Hsu, Lay-Sun Ma, Yin-Yuin Pang, Ming-Daw Tsai, Erh-Min Lai   +6 more
doaj   +1 more source