Results 131 to 140 of about 24,060,770 (296)

The Vibrio type VI secretion system induces intestinal macrophage redistribution and enhanced intestinal motility

mBio
Intestinal microbes, whether resident or transient, influence the physiology of their hosts, altering both the chemical and the physical characteristics of the gut. An example of the latter is the human pathogen Vibrio cholerae’s ability to induce strong
Julia S. Ngo, Piyush Amitabh, Jonah G. Sokoloff, Calvin Trinh, Travis J. Wiles, Karen Guillemin, Raghuveer Parthasarathy   +6 more
doaj   +1 more source

Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition

MicrobiologyOpen, 2019
Burkholderia cenocepacia is an opportunistic bacterial pathogen that poses a significant threat to individuals with cystic fibrosis by provoking a strong inflammatory response within the lung.
Helena L. Spiewak, Sravanthi Shastri, Lili Zhang, Stephan Schwager, Leo Eberl, Annette C. Vergunst, Mark S. Thomas   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Genome sequence reveals that Pseudomonas fluorescens F113 possesses a large and diverse array of systems for rhizosphere function and host interaction [PDF]

, 2013
Background: Pseudomonas fluorescens F113 is a plant growth-promoting rhizobacterium (PGPR) isolated from the sugar-beet rhizosphere. This bacterium has been extensively studied as a model strain for genetic regulation of secondary metabolite production ...
María Sánchez-Contreras, Rivilla Palma, Rafael, Germaine, Kieran, O’Gara, Fergal, Dowling, David N., David Dowling, Sánchez-Contreras, María, Ana Navazo, Rafael Rivilla, Candela, Muriel, Martínez-Granero, Francisco, Barahona, Emma, Martinez-Granero, F., Emma Barahona, Fergal, O´Gara, Francisco Martínez-Granero, Martín, M., Redondo Nieto, Miguel, Morrissey, John P., Sánchez-Contreras, M., Candela Muriel, Barret, M., Moynihan, J., Martín Basanta, Marta, Germaine, K., Barahona, E., Navazo, A., John Morrissey, Jennifer A Moynihan, Sánchez-Contrerasa, María, Dowling, D., Moynihan, Jennifer A., Miguel Redondo-Nieto, Martín, Marta, Navazo, Ana, Morrissey, John, O\u27Gara, Fergal, Moynihan, Jennifer A, Muriel, C., Fergal O’Gara, Barret, Matthieu, Matthieu Barret, Rivilla, Rafael, Moynihan, Jennifer, Morrissey, J., Redondo-Nieto, M., Kieran Germaine, Marta Martín, Redondo-Nieto, Miguel, Rivilla, R., Muriel, Candela, Germaine, Kieran J., Dowling, David, O'Gara, Fergal   +53 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Prevalence and mapping of a plasmid encoding a type IV secretion system in Acinetobacter baumannii

, 2017
We investigated the prevalence of a type IV secretion system (T4SS)-bearing plasmid among clinical isolates of carbapenem-resistant Acinetobacter baumannii (CRAB) using plasmid replicon typing.
Liu, Chih-Chin;Kuo, Han-Yueh;Tang, Chuan Yi;Chang, Kai-Chih;Liou, Ming-Li, 郭漢岳;郭弘揚   +1 more
core   +1 more source

A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens [PDF]

, 2014
Pathogenic bacteria adapt to their environment and manipulate the biochemistry of hosts by secretion of effector molecules. Serratia marcescens is an opportunistic pathogen associated with healthcare-acquired infections and is a prolific secretor of ...
Guo, Manman, Sargent, Frank, Sarah J. Coulthurst, Buchanan, Grant, Stanley-Wall, Nicola R.; id_orcid, Nicola R. Stanley-Wall, Owen, Richard A., Trost, Matthias, Govind Chandra, Coulthurst, Sarah J.; id_orcid, Matthias Trost, Tracy Palmer, Costa, Marília de Assis Alcoforado, Victoria L. Marlow, Richard A. Owen, Palmer, Tracy, Jaeger J. Hamilton, Hamilton, Jaeger J., Manman Guo, Marlow, Victoria L., Grant Buchanan, Chandra, Govind, Marília de Assis Alcoforado Costa, Frank Sargent   +23 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source