Results 251 to 260 of about 25,500,999 (291)

The Pseudomonas aeruginosa Type VI secretion system toxin Tse8 evolved from a novel N-carbamoylputrescine amidohydrolase. [PDF]

Biochem J
Li B, Baniasadi HR, Phillips MA, Michael AJ.   +3 more
europepmc   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

Advanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo, Nuria Matesanz, Jorge‐Luis Torres, Alba C. Arcones, Juan Ignacio Jiménez‐Loygorri, Alfonso Mora, Leticia Herrera‐Melle, Luis Leiva‐Vega, Maria Elena Rodriguez, Lourdes Hernández‐Cosido, Marta Leon, Paula Yong González, Teresa Durán, Tamara Parracho, Francisca Mulero, Rubén Nogueiras, J. Simon C. Arthur, Angel R. Nebreda, Roger J. Davis, Miguel Marcos, Guadalupe Sabio   +20 more
wiley   +1 more source

Cyclic di-GMP Modulation of Quorum Sensing and Its Impact on Type VI Secretion System Function in <i>Sinorhizobium fredii</i>. [PDF]

Microorganisms
Aranda-Pérez J, Sánchez-Aguilar MDC, Cutiño-Gobea AM, Pérez-Montaño F, Medina C.   +4 more
europepmc   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

A mutualistic model bacterium is lethal to non-symbiotic hosts via the type VI secretion system. [PDF]

mBio
Gaddy KE, Septer AN, Mruk K, Milton ME.
europepmc   +1 more source

The Negative Regulatory Role of Transcriptional Regulator H-NS on the Type VI Secretion System in <i>Acinetobacter baumannii</i>. [PDF]

Infect Drug Resist
Zhang Y, Zhou H, Kong J, Hu P, Zhang Y, Cao J, Zhou B.   +6 more
europepmc   +1 more source

TagF coordinates spike-loading as an intermediate checkpoint in Type VI Secretion System assembly

Engelin MK, Prakash P, Lin L, Mühlethaler T, Heynisch A, Pereira J, Delbart F, Kuhn EMA, Baker D, Maier T, Basler M.   +10 more
europepmc   +1 more source

Regulation of the H1 Type VI Secretion System by the Transcriptional Regulator NfxB in <i>Pseudomonas aeruginosa</i>. [PDF]

Int J Mol Sci
Liu S, Wu Z, Yan W, Liu Q, Zhao Y, Gao T, Yang Y, Cao L, Tao R, Li M, Liu L, Zhang Y, Wang T.   +12 more
europepmc   +1 more source

Not just passengers: effectors contribute to the assembly of the type VI secretion system as structural building blocks. [PDF]

J Bacteriol
Dyrma S, Pei T-T, Liang X, Dong T.
europepmc   +1 more source

Identification of Antimicrobial Resistance Patterns, Type VI Secretion System, and Virulence Factors in Clinical Isolates of <i>Klebsiella pneumoniae</i>: A Cross-Sectional Study. [PDF]

Int J Microbiol
Haddadi MH, Taki E, Maleki A, Mashhadi J, Shahi F, Koupaei M, Sadeghifard N, Faraji R, Moradi M, Valadbeigi H, Khoshnood S.   +10 more
europepmc   +1 more source