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Bacterial Defense against the Type VI Secretion System

Trends in Microbiology, 2021
Bacteria have evolved systems dedicated to interbacterial competition. Here we highlight defenses utilized by Gram-negative cells against type VI secretion system (T6SS)-wielding competitors, including physical barriers, genetically encoded antidotes, and stress responses.
Sophie, Robitaille   +2 more
openaire   +2 more sources

Type VI Secretion System: A Modular Toolkit for Bacterial Dominance [PDF]

open access: yesFuture Microbiology, 2019
Bacteria use toxin delivery systems, such as the type VI secretion system (T6SS), to antagonize competitors. The T6SS transports toxins, called effectors, directly into recipient cells. In the absence of cognate immunity proteins that protect against kin-intoxication, these effectors target conserved and essential cell components resulting in growth ...
Dor Salomon, Biswanath Jana
exaly   +3 more sources

Rules of Engagement: The Type VI Secretion System in Vibrio cholerae [PDF]

open access: yesTrends in Microbiology, 2017
Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins.
Fitnat H Yıldız   +2 more
exaly   +3 more sources

Bacterial strategies for immune systems — Role of the type VI secretion system

International Immunopharmacology, 2023
The process of host infection by bacteria is complicated. Bacterial infections strongly induce the host immune system, which necessitates a robust clearance of the infection. However, bacteria have over time developed strategies that enable their evasion of attacks by the host immune system.
Yurou Wang   +5 more
openaire   +2 more sources

Identification of type VI secretion systems in Moritella viscosa

Veterinary Microbiology, 2012
The study describes the identification of type VI secretion systems (T6SSs) in Moritella viscosa, the aetiological agent of winter ulcer disease. Despite the availability of commercial vaccines, M. viscosa causes significant financial losses in salmonid farming.
Bryndis, Bjornsdottir   +5 more
openaire   +2 more sources

The type VI secretion system and associated effector proteins

Nature Reviews Microbiology
Bacteria have evolved a myriad of antibacterial weapons to engage in interbacterial conflicts. Among these, many Gram-negative bacteria use type VI secretion systems (T6SSs), which are contractile toxin delivery systems, to eliminate or suppress competitors in a contact-dependent manner.
Jan C. Wohlfarth   +3 more
openaire   +2 more sources

Expression, secretion and bactericidal activity of type VI secretion system in Vibrio anguillarum

Archives of Microbiology, 2016
The type VI secretion system (T6SS) was recently shown to modulate quorum sensing and the stress response in Vibrio anguillarum serotype O1 strain NB10. It is not known whether there is a functionally active T6SS in other serotypes of V. anguillarum. Here, homologues to T6SS cluster VtsEFGH and hemolysin-coregulated protein (Hcp)-encoding genes were ...
Lei, Tang   +6 more
openaire   +2 more sources

Dissection of a type VI secretion system in Edwardsiella tarda

Molecular Microbiology, 2007
SummaryBacterial pathogens use different protein secretion systems to deliver virulence factors. Recently, a novel secretion system was discovered in several Gram‐negative bacterial pathogens, and was designated as the type VI secretion system (T6SS). In Edwardsiella tarda, a partial E. tardavirulent protein (EVP) gene cluster was implicated in protein
Zheng, J., Leung, K.Y.
openaire   +2 more sources

Type VI Secretion Systems encoded by plasmids

2022
Trabajo presentado en la conferencia "Plasmids around the Globe", celebrada en modalidad virtual el 06 de mayo de 2021.
Quiñonero Coronel, María del Mar   +1 more
openaire   +1 more source

The Type VI secretion system – a widespread and versatile cell targeting system

Research in Microbiology, 2013
The Type VI secretion system (T6SS) is the most recently described of the Gram-negative bacterial secretion systems and is widely distributed amongst diverse species. T6SSs are currently believed to be complex molecular machines which inject effector proteins into target cells and which incorporate a bacteriophage-like cell-puncturing device.
openaire   +3 more sources

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