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Bacterial Defense against the Type VI Secretion System
Trends in Microbiology, 2021Bacteria have evolved systems dedicated to interbacterial competition. Here we highlight defenses utilized by Gram-negative cells against type VI secretion system (T6SS)-wielding competitors, including physical barriers, genetically encoded antidotes, and stress responses.
Sophie, Robitaille +2 more
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Type VI Secretion System: A Modular Toolkit for Bacterial Dominance [PDF]
Bacteria use toxin delivery systems, such as the type VI secretion system (T6SS), to antagonize competitors. The T6SS transports toxins, called effectors, directly into recipient cells. In the absence of cognate immunity proteins that protect against kin-intoxication, these effectors target conserved and essential cell components resulting in growth ...
Dor Salomon, Biswanath Jana
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Rules of Engagement: The Type VI Secretion System in Vibrio cholerae [PDF]
Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins.
Fitnat H Yıldız +2 more
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Bacterial strategies for immune systems — Role of the type VI secretion system
International Immunopharmacology, 2023The process of host infection by bacteria is complicated. Bacterial infections strongly induce the host immune system, which necessitates a robust clearance of the infection. However, bacteria have over time developed strategies that enable their evasion of attacks by the host immune system.
Yurou Wang +5 more
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Identification of type VI secretion systems in Moritella viscosa
Veterinary Microbiology, 2012The study describes the identification of type VI secretion systems (T6SSs) in Moritella viscosa, the aetiological agent of winter ulcer disease. Despite the availability of commercial vaccines, M. viscosa causes significant financial losses in salmonid farming.
Bryndis, Bjornsdottir +5 more
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The type VI secretion system and associated effector proteins
Nature Reviews MicrobiologyBacteria have evolved a myriad of antibacterial weapons to engage in interbacterial conflicts. Among these, many Gram-negative bacteria use type VI secretion systems (T6SSs), which are contractile toxin delivery systems, to eliminate or suppress competitors in a contact-dependent manner.
Jan C. Wohlfarth +3 more
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Expression, secretion and bactericidal activity of type VI secretion system in Vibrio anguillarum
Archives of Microbiology, 2016The type VI secretion system (T6SS) was recently shown to modulate quorum sensing and the stress response in Vibrio anguillarum serotype O1 strain NB10. It is not known whether there is a functionally active T6SS in other serotypes of V. anguillarum. Here, homologues to T6SS cluster VtsEFGH and hemolysin-coregulated protein (Hcp)-encoding genes were ...
Lei, Tang +6 more
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Dissection of a type VI secretion system in Edwardsiella tarda
Molecular Microbiology, 2007SummaryBacterial pathogens use different protein secretion systems to deliver virulence factors. Recently, a novel secretion system was discovered in several Gram‐negative bacterial pathogens, and was designated as the type VI secretion system (T6SS). In Edwardsiella tarda, a partial E. tardavirulent protein (EVP) gene cluster was implicated in protein
Zheng, J., Leung, K.Y.
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Type VI Secretion Systems encoded by plasmids
2022Trabajo presentado en la conferencia "Plasmids around the Globe", celebrada en modalidad virtual el 06 de mayo de 2021.
Quiñonero Coronel, María del Mar +1 more
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The Type VI secretion system – a widespread and versatile cell targeting system
Research in Microbiology, 2013The Type VI secretion system (T6SS) is the most recently described of the Gram-negative bacterial secretion systems and is widely distributed amongst diverse species. T6SSs are currently believed to be complex molecular machines which inject effector proteins into target cells and which incorporate a bacteriophage-like cell-puncturing device.
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