Results 141 to 150 of about 54,266 (256)

Divergent Atrial Transcriptomic Signatures in Diabetic and Nondiabetic Atrial Fibrillation

Journal of Arrhythmia, Volume 42, Issue 4, August 2026.
Diabetes alters the atrial transcriptome in atrial fibrillation, characterized by enhanced mitochondrial ATP synthesis, suppressed immune and inflammatory pathways, and distinct miRNA expression profiles, suggesting metabolic and epigenetic remodeling of the atrial substrate.
Kenshi Yoshimura, Yuya Kiriake, Hiroki Osanai, Mengyan Wei, Shinichiro Kume, Tatsuki Kurokawa, Masaki Morishima, Ryusuke Suzuki, Shinji Miyamoto, Katsushige Ono   +9 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Targeting Melanoma‐Specific Tyrosinase Disrupts Cytoskeleton Dynamics for Precision Apoptosis Induction by a De Novo Designed Cyclic Peptide

MedComm, Volume 7, Issue 8, August 2026.
This study develops a tyrosinase‐activated cyclic peptide self‐assembly system to combat drug‐resistant melanoma. Cyclization of tyrosine/lysine‐rich peptides via ortho‐phthalaldehyde enables tyrosinase‐triggered quinone formation and nanostructure assembly, disrupting melanoma cell cytoskeletons by blocking actin polymerization and inducing apoptosis.
Ruoyang Zhao, Xiaowei Wang, Jiajia Hu, Yonghan Zhang, Xinmin Zhao, Qianqian Hu, Yajin Wen, Yuxin Jiao, Huabin Zhu, Fan Yang, Qingqing Sun, Jun Guo, Feng Zhang, Min Wu   +13 more
wiley   +1 more source

Computational and biochemical evidence reveal cuminaldehyde as a potent tyrosinase inhibitor

Discover Chemistry
Inhibition of enzymes has been a major drug target for curing diseases. Xanthine oxidase is involved in the production of uric acid. The enzyme has elevated levels of activity in various diseases like gout, cardiovascular diseases etc.
Taranga Jyoti Baruah, Sthiti Porna Dutta, Partha Pratim Das, Muskan Sonam Darjee, Dikshit Deka, Jutishna Bora, Sumira Malik, Amlan Das   +7 more
doaj   +1 more source

Tyrosinase in Macrolepidoptera [PDF]

Biochemical Journal, 1934
openaire   +2 more sources

Metal Halide Perovskite Quantum Dots for Luminescence Sensing and Imaging

Nano Select, Volume 7, Issue 8, August 2026.
This review highlights recent advances in metal halide perovskite quantum dots (PQDs)‐based photoluminescence, chemiluminescence, and electroluminescence sensing methods, as well as bioimaging applications. Key challenges, potential solutions, and future opportunities are discussed to guide the development of robust PQD‐based sensing platforms ...
Tooba Hallaj, Rana Salari, Seyyed Morteza Seyyed Alavi, Muhammad Munir, Niko Hildebrandt, Mohammad Amjadi   +5 more
wiley   +1 more source

Low Sunscreen Awareness and Misconceptions in Skin of Colour With Acne‐Related Post‐Inflammatory Hyperpigmentation: A Cross‐Sectional Study Highlighting the Need for Targeted Education

Australasian Journal of Dermatology, Volume 67, Issue 5, Page e299-e306, August 2026.
ABSTRACT Background/Objectives Post‐inflammatory hyperpigmentation (PIH) is a frequent sequela of acne in patients with skin of colour (SOC). While sunscreen is widely recommended for PIH prevention, little is known about real‐world sunscreen practices in this group. This study aimed to evaluate sunscreen use, barriers and factors influencing adherence
Xiaozhun Hang, Davin Sui Lim, Lisa Byrom
wiley   +1 more source

Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity

Pharmaceutical and Biomedical Research, 2015
Tyrosinase is a key enzyme for melanin biosynthesis, catalyzing the oxidation of L-tyrosine to L-dopaquinone. The tyrosinase inhibition is an effective approach to control hyperpigmentation in human skin and enzymatic browning in fruits and vegetables ...
Seyedeh Mahdieh Hashemi, Saeed Emami
doaj  

Recent advances of emergent extraction technologies to enhance bioactive compounds extraction of microalgae—An overview towards application in cosmetics

International Journal of Cosmetic Science, Volume 48, Issue 4, Page 884-910, August 2026.
Microalgae extracts show immense potential in cosmetics for their bioactivities; emerging extraction techniques enhance bioactive compound yield from microalgae. Abstract Microalgae have attracted significant interest in numerous sectors, particularly in the cosmetic industries, owing to their rich composition of bioactive compounds. This paper aims to
Alireza Mousakhani Ganjeh, Lucília da P. da Silva, Carlos A. Pinto, Rosário Martins, Alexandra P. Marques, Jorge A. Saraiva   +5 more
wiley   +1 more source

Diagnostic Challenges in Choroid Plexus Tumours

Neuropathology and Applied Neurobiology, Volume 52, Issue 4, August 2026.
In this review, we summarise the diagnostic spectrum of choroid plexus tumours, highlight key age‐dependent differential diagnoses across infants, children/adolescents and adults, and outline how histopathology, immunohistochemistry and molecular profiling support accurate tumour classification.
Christian Thomas, Martin Hasselblatt
wiley   +1 more source